Publications

Peer-reviewed research articles

• Somppi S, Törnqvist H, Topál J, Koskela A, Hänninen L, Krause CM and Vainio O. 2017. Nasal Oxytocin Treatment Biases Dogs’ Visual Attention and Emotional Response toward Positive Human Facial Expressions. Front. Psychol. 8:1854. doi: 10.3389/fpsyg.2017.01854
• Kujala MV. 2017. Canine emotions as seen through human social cognition. Animal Sentience 14(1)
• Somppi S, Törnqvist H, Kujala MV, Hänninen L, Krause CM, Vainio O. 2016. Dogs evaluate threatening facial expressions by their biological validity – evidence from gazing patterns. Plos ONE 11(1): e0143047. DOI:10.1371/journal.pone.0143047
• Törnqvist H, Somppi S, Koskela A, Krause CM, Vainio O, Kujala MV. 2015. Comparison of dogs and humans in visual scanning of social interaction. Royal Society Open Science 2015 Sep 30;2(9):150341. DOI: 10.1098/rsos.150341
• Somppi S, Törnqvist H, Hänninen L, Krause CM, Vainio O. 2014. How dogs scan familiar and inverted faces: an eye movement study. Animal Cognition 17: 793-803. DOI: 10.1007/s10071-013-0713-0
• Kujala MV, Törnqvist H, Somppi S, Hänninen L, Krause CM, Vainio O, Kujala J. 2013. Reactivity of Dogs’ Brain Oscillations to Visual Stimuli Measured with Non-Invasive Electroencephalography. PLoS ONE 8(5): e61818. DOI:10.1371/journal.pone.0061818
• Törnqvist H, Kujala MV, Somppi S, Hänninen L, Pastell M, Krause CM, Kujala J, Vainio O. 2013. Visual event-related potentials of dogs: a non-invasive electroencephalography study. Animal Cognition 16: 973-982. DOI 10.1007/s10071-013-0630-2
• Somppi S, Törnqvist H, Hänninen L, Krause C, Vainio O. 2012. Dogs do look at images: eye tracking in canine cognition research. Animal Cognition 15: 163-174. DOI 10.1007/s10071-011-0442-1

Conference presentations and posters

• Somppi S, Törnqvist H, Koskela A, Krause CM, Topál J, Vainio O. 2016. Nasal oxytocin enhances gazing at eyes of smiling humans in domestic dogs. The 5th Canine Science Symposium, Padova, Italy.
• Kujala MV, Kujala J, Törnqvist H, Vainio O, Parkkonen L. 2016. Dogs’ brain responses to faces and objects measured with non-invasive electroencephalography. 8th European Conference of Comparative Neurobiology, Munich, Germany.
• Kujala MV, Somppi S, Koskela AM, Törnqvist H, Vainio O, Parkkonen L. 2014. Valence and arousal ratings of dogs and human facial expressions by human observers. The 4rd Canine Science Forum, Lincoln, England.
• Somppi S, Törnqvist H, Kujala MV, Koskela A, Hänninen L, Krause CM, Vainio O. 2014. Facial expressions modulate scanning pattern in domestic dogs. The 4rd Canine Science Forum, Lincoln, England.
• Norring M, Somppi S, Törnqvist H, Hänninen L, Vainio O. 2014. Cognition studies refined with pet animals. The 9th World Congress on Alternatives and Animal Use in the Life Sciences, Prague, Czech Republic.
• Somppi S, Törnqvist H, Hänninen L, Krause CM, Vainio O. 2013. How dogs process inverted and familiar faces. The 47th ISAE International Congress, Florianopolis, Brazil.
• Törnqvist H, Kujala MV, Somppi S, Koskela A, Krause CM, Vainio O. 2013. How dogs and humans observe images of natural social interaction: a comparative eye-tracking study. 3rd Transfer-of-knowledge conference of the Evolution of Comparative Cognition,Vienna, Austria.
• Kujala MV, Törnqvist H, Somppi S, Hänninen L, Krause CM, Kujala J, Vainio O. 2013. Cognitive brain oscillations associated with visual perception in humans and dogs. 3rd Transfer-of-knowledge conference of the Evolution of Comparative Cognition,Vienna, Austria.
• Törnqvist H, Kujala MV, Somppi S, Hänninen L, Pastell M, Krause CM, Kujala J, Vainio O. 2012. Visual event-related potentials of dogs recorded with fully non-invasive electroencephalography. The 3rd Canine Science Forum, Barcelona, Spain.
• Somppi S, Törnqvist H, Hänninen L, Krause CM, Vainio O. 2012. How dogs process familiar and inverted faces, an eye movement study. The 3rd Canine Science Forum, Barcelona, Spain.
• Somppi S, Törnqvist H, Hänninen L, Krause CM, Vainio O. 2011. How dogs process faces: an eye movement study. The 2nd Transfer-of-knowledge conference of the Evolution of Comparative Cognition, Prague, Czech Republic.
• Somppi S, Törnqvist H, Hänninen L, Krause CM, Vainio O. 2010. Dogs do look at images – Eye tracking in canine cognition research. The 2nd Canine Science Forum, Vienna, Austria.
• Somppi S, Malkamäki S, Valros A. 2010. Aggression toward people by rottweiler dogs. The 44th International Congress of the Society for Applied Ethology, Uppsala, Sweden.

Peer-reviewed research articles

• Kujala MV, Somppi S, Jokela M, Vainio O, Parkkonen L. 2017. Human Empathy, Personality and Experience Affect the Emotion Ratings of Dog and Human Facial Expressions. PLoS ONE 12(1): e0170730. doi:10.1371/journal.pone.0170730
• Törnqvist H, Somppi S, Koskela A, Krause CM, Vainio O, Kujala MV. 2015. Comparison of dogs and humans in visual scanning of social interaction. Royal Society Open Science 2(9): 150341. DOI: 10.1098/rsos.150341
• Norring M, Wikman I, Hokkanen A-H, Kujala MV, Hänninen L. 2014. Empathic veterinarians score cattle pain higher. The Veterinary Journal 200 (1): 186-190. DOI: 10.1016/j.tvjl.2014.02.005
• Kujala MV, Kujala J, Carlson S, Hari R. 2012. Dog experts’ brains distinguish socially relevant body postures similarly in dogs and humans. PLoS ONE 7(6): e39145. DOI: 10.1371/journal.pone.0039145

Conference presentations and posters

• Kujala MV, Somppi S, Jokela M, Vainio O, Parkkonen L. 2016. How humans estimate emotions from dog and human faces – Connections to empathy, personality and experience. Animal and Human Emotions, Erice, Sicily, Italy.
• Kujala MV. 2015. Koiran ja ihmisen sosiaalinen mieli. (finnish) Think Corner, Helsinki, Finland.
• Kujala MV, Somppi S, Koskela A, Törnqvist H, Vainio O, Parkkonen L. 2014. Valence and arousal ratings of dogs and human facial expressions by human observers. The 4rd Canine Science Forum, Lincoln, England.
• Kujala MV. 2013. Visual perception of social stimuli in humans and dogs - Why and how to compare processing across species? 2nd BRAHE Symposium, Helsinki, Finland.
• Kujala MV. 2013. Of dogs and humans: How do humans see social gestures of non-human species? Animal Concepts, Helsinki, Finland.
• Törnqvist H, Kujala MV, Somppi S, Koskela A, Krause CM, Vainio O. 2013. How dogs and humans observe images of natural social interaction: a comparative eye-tracking study. 3rd Transfer-of-knowledge conference of the Evolution of Comparative Cognition, Vienna, Austria.
• Kujala MV, Törnqvist H, Somppi S, Hänninen L, Krause CM, Kujala J, Vainio O. 2013. Cognitive brain oscillations associated with visual perception in humans and dogs. 3rd Transfer-of-knowledge conference of the Evolution of Comparative Cognition, Vienna, Austria.
• Kujala MV. 2013. Mitä aivoissamme tapahtuu kun katsomme koiraa? (finnish) Think Corner, Helsinki, Finland.

• Kujala MV, Carlson S, Hari R. 2011. Dog experts read social interaction of dogs and humans alike: Expertise-related brain correlates of reading body postures across species. 2nd Transfer-of-knowledge conference of the Evolution of Comparative Cognition, Prague, Czeck Republic.

Peer-reviewed research articles

• Savolainen S, Telkänranta H, Junnila J, Hautala J, Airaksinen S, Juppo A, Raekallio M, Vainio O. 2016. A novel set of behavioural indicators for measuring perception of food by cats. The Veterinary Journal 216: 53–58. DOI: 10.1016/j.tvjl.2016.06.012
• Hemmann K, Ahonen S, Raekallio M, Vainio O & Lohi H. 2014. Exploration of known stereotypic behaviour-related candidate genes in equine crib-biting. Animal. 8: 347-353. DOI: 10.1017/S1751731113002346
• Hemmann K, Raekallio M, Vainio O & Juga J. 2014. Crib-biting and its heritability in Finnhorses. Applied Animal Behaviour Science 156: 37-43. DOI: 0.1016/j.applanim.2014.04.008
• Petersen JL, Mickelson JR, Cothran EG, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, Machado ADC, Distl O, Felicetti M, Fox-Clipsham L, Graves KT, Guerin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MC, Piercy RJ, Raekallio M, Rieder S, Røed KH, Silvestrelli M, Swinburne J, Tozaki T, Vaudin M, Wade CMT, McCue ME. 2013. Genetic Diversity in the Modern Horse Illustrated from Genome-Wide SNP Data. PLoS ONE 8(1): e54997. DOI: 10.1371/journal.pone.0054997
• Petersen JL, Mickelson JR, Rendahl AK, Valberg SJ, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, Machado ADC, Capomaccio S, Cappelli K, Cothran EG, Distl O, Fox-Clipsham L, Graves KT, Guerin G, Haase B, Hasegawa T, Hemmann K, Hill,EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MCT, Piercy RJ, Raekallio M, Rieder S, Røed KH, Swinburne J, Tozaki T, Vaudin M, Wade CM, McCue ME. 2013. Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds. PLoS Genet 9(1): e1003211. DOI:10.1371/journal.pgen.1003211
• Hemmann KE, Koho NM, Vainio OM, Raekallio MR. 2013. Effects of feed on plasma leptin and ghrelin concentrations in crib-biting horses. The Veterinary Journal. 198: 122-126. DOI: 10.1016/j.tvjl.2013.06.002
• Vainionpää M, Salla K, Restitutti F, Raekallio M, Junnila J, Snellman M, Vainio O. 2013. Thermographic imaging of superficial temperature in dogs sedated with medetomidine and butorphanol with and without MK-467 (L-659'066). Vet Anaesth Analg 40: 142-148. DOI: 10.1111/j.1467-2995.2012.00768.x.
• Hemmann K, Raekallio M, Kanerva K, Hänninen L, Pastell M, Palviainen M. Vainio O. 2012. Circadian variation in ghrelin and certain stress hormones in crib-biting horses. The Veterinary Journal. 193, 1, s. 97-102. DOI: 10.1016/j.tvjl.2011.09.027
• Vainionpää MH, Raekallio MR, Junnila JJT, Hielm-Björkman AK, Snellman MPM, Vainio OM. 2012. A comparison of thermographic imaging, physical examination, and modified questionnaire as an instrument to assess painful conditions in cats. J Feline Med Surg 15: 124-131. DOI: 10.1177/1098612X12463926
• Vainionpää M, Raekallio M, Tuhkalainen E, Hänninen H, Alhopuro N, Savolainen M, Junnila J, Hielm-Björkman A, Snellman M, Vainio O. 2012. Comparison of three thermal cameras with canine hip area thermographic images. J Vet Med Sci. 74: 1539-44. DOI: 10.1292/jvms.12-0180
• Vainionpää M, Tienhaara EP, Raekallio M, Junnila J, Snellman M, Vainio O. 2012. Thermographic imaging of the superficial temperature in racing greyhounds before and after the race. Scientific World Journal. 2012:182749. DOI: 10.1100/2012/182749.

Conference presentation and posters

• Telkänranta H, Koskela A, Pierard M, Menor-Campos DJ, Kujala MV, Törnqvist H, Somppi S, Vainio O, Vainionpää M. 2016. Thermal imaging: a non-invasive technique to measure physiological processes linked to emotions. Measuring Animal Emotions workshop, Edinburgh, Scotland.

• Telkänranta H, Koskela A, Pierard M, Menor-Campos DJ, Kujala MV, Törnqvist H, Somppi S, Vainio O, Vainionpää M. 2016. Infrared thermography as a non-invasive tool for quantifying emotional arousal in rats, dogs and elephants: recent findings and methodological aspects. Animal and Human Emotions, Erice, Sicily, Italy.

Peer-reviewed research articles (since 2000)

• Kallio-Kujala IJ, Raekallio MR, Honkavaara J, Bennett RC, Turunen H, Scheinin M, Hautajärvi H, Vainio O. 2018. Peripheral α2-adrenoceptor antagonism affects the absorption of intramuscularly coadministered drugs. Vet Anaesth Analg. 2018 Feb 3. pii: S1467-2987(18)30019-9. doi: 10.1016/j.vaa.2018.01.008. [Epub ahead of print]

• Pakkanen SAE, de Vries A, Raekallio MR, Mykkänen AK, Palviainen MJ, Sankari SM, Vainio OM. 2018. Changes in energy metabolism, and levels of stress-related hormones and electrolytes in horses after intravenous administration of romifidine and the peripheral α-2 adrenoceptor antagonist vatinoxan. Acta Vet Scand. 2018, 60, 27. doi: 10.1186/s13028-018-0380-x

• Adam M, Raekallio MR, Keskitalo T, Honkavaara JM, Scheinin M, Kajula M, Mölsä S, Vainio OM. The impact of MK-467 on plasma drug concentrations, sedation and cardiopulmonary changes in sheep treated with intramuscular medetomidine and atipamezole for reversal. J Vet Pharmacol Ther. 2018, 41, 447-456. doi: 10.1111/jvp.12486.

• Wittenberg-Voges L, Kästner SB, Raekallio M, Vainio OM, Rohn K, Hopster K. 2018. Effect of dexmedetomidine and xylazine followed by MK-467 on gastrointestinal microperfusion in anaesthetized horses. Vet Anaesth Analg. 2018, 45, 165-174. doi: 10.1016/j.vaa.2017.08.010.

• Tapio HA, Raekallio MR, Mykkänen A, Mama K, Mendez-Angulo JL, Hautajärvi H, Vainio OM. 2018. Effects of MK-467 hydrochloride and hyoscine butylbromide on cardiorespiratory and gastrointestinal changes induced by detomidine hydrochloride in horses. Am J Vet Res. 2018, 79, 376-387. doi: 10.2460/ajvr.79.4.376.

• Salla KM, Tuns CI, Bennett RC, Raekallio MR, Scheinin M, Kuusela E, Vainio OM. 2017. Cardiovascular effects of premedication with medetomidine alone and in combination with MK-467 or glycopyrrolate in dogs subsequently anesthetized with isoflurane. Am J Vet Res. 2017, 78, 1245-1254. doi: 10.2460/ajvr.78.11.1245

• Ala-Kurikka E, Heinonen M, Mustonen K, Peltoniemi O, Raekallio M, Vainio O, Valros A. 2017. Behavior changes associated with lameness in sows. Applied Animal Behaviour Science 2017, 193, 15-20. doi: 10.1016/j.applanim.2017.03.017

• Bennett R, Palviainen M, Peltoniemi M, Vuorilehto L, Scheinin M, Raekallio M, Vainio O. 2017. The role of active transport in the transcellular movement of the peripheral α2-adrenoceptor antagonist, MK-467: an in vitro pilot study. Can J Vet Res 2017, 81, 318-320.

• Hector RC, Rezende ML, Mama KR, Steffey EP, Knych HK, Hess AM, Honkavaara JM, Raekallio MR, Vainio OM. 2017. Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg. 2017 Mar 4. pii: S1467-2987(17)30086-7. doi: 10.1016/j.vaa.2016.12.058. [Epub ahead of print]

• Raekallio M, Virtanen M, Happonen I, Vainio O. 2017. Adverse reactions of α2-adrenoceptor agonists in cats reported in 2003-2013 Finland. Vet Anaesth Analg. 2017 Mar 1. pii: S1467-2987(17)30077-6. doi: 10.1016/j.vaa.2016.07.008. [Epub ahead of print]

• Bennett RC, Salla KM, Raekallio MR, Scheinin M, Vainio OM. 2017. Effects of the α2-adrenoceptor agonist medetomidine on the distribution and clearance of alfaxalone during coadministration by constant rate infusion in dogs. Am J Vet Res. 2017 78, 956-964. doi: 10.2460/ajvr.78.8.956

• Restitutti F, Kaartinen MJ, Raekallio MR, Wejberg O, Mikkola E, del Castillo JRE, Scheinin M, Vainio OM. 2017. Plasma concentration, cardiovascular and sedative effects of intramuscular medetomidine with three doses of the peripheral alpha-2 antagonist MK-467 in dogs. Vet Anaesth Analg. 2017, 44, 417-426. doi: 10.1016/j.vaa.2016.04.006

• Sivén M, Savolainen S, Räntilä S, Männikkö S, Vainionpää M, Airaksinen S, Raekallio M, Vainio O, Juppo AM. 2017. Difficulties in administration of oral medication formulations to pet cats: an e-survey of cat owners. Vet Rec. 201, 180, 250. doi: 10.1136/vr.103991

• de Vries A, Pakkanen S, Raekallio MR, Ekiri A, Scheinin M, Taylor P, Vainio O. 2016. Clinical effects and pharmacokinetic variables of romifidine and the peripheral a2-adrenoceptor antagonist MK-467 in horses. Veterinary Anaesthesia and Analgesia. 2016: 1-12. DOI: 10.1111/vaa.12354

• Bennett R, Salla KM, Raekallio MR, Hänninen LT, Rinne VM, Vainio-Kivinen OM. 2016. Effects of MK-467 on the antinociceptive and sedative actions and pharmacokinetics of medetomidine in dogs. Journal of Veterinary Pharmacology and Therapeutics 39: 336-343. DOI: 10.1111/jvp.12292

• Bennett RC, Hokkanen J, Raekallio MR, Vainio OM. 2016. The impact of medetomidine on the protein-binding characteristics of MK-467 in canine plasma. J Vet Pharmacol Ther. 39: 405-407. DOI: 10.1111/jvp.12291

• Viitasaari E, Raekallio M, Valros A, Peltoniemi O, Hanninen L, Heinonen M. 2016. The effect of ketoprofen on feeding behavior of tail-bitten pigs. Porcine Health Management 1:11. DOI: 10.1186/s40813-015-0005-y

• Pakkanen SAE, Raekallio MR, Mykkänen AK, Salla KM, de Vries A, Vuorilehto L, Scheinin M, Vainio OM. 2015. Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane. Veterinary Anaesthesia and Analgesia. 42: 527-536. DOI: 10.1111/vaa.12238

• Palviainen MJ, Junnikkala S, Raekallio M, Meri S, Vainio O. 2015. Activation of complement system in kidney after ketoprofen-induced kidney injury in sheep.  Acta Vet Scand 57:15. DOI: 10.1186/s13028-015-0106-2

• Kaartinen J, del Castillo JRE, Salla K, Troncy E, Raekallio MR, Vainio OM. 2014. Haemodynamic interactions of medetomidine and the peripheral alpha-2 antagonist MK-467 during step infusions in isoflurane-anaesthetised dogs. Vet J 202: 353-360. DOI: 10.1016/j.tvjl.2014.08.019

• Salla K, Restitutti F, Vainionpää M, Junnila J, Honkavaara J, Kuusela E, Raekallio M, Vainio O. 2014. The cardiopulmonary effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in dogs sedated with a combination of medetomidine and butorphanol. Vet Anaesth Analg 41: 567-574. DOI: 10.1111/j.1365-2885.2010.01242.x

• Hokkanen AH, Raekallio MR, Salla K, Hänninen L, Viitasaari E, Norring M, Raussi S, Rinne VM, Scheinin M, Vainio OM. 2014. Sublingual administration of detomidine to calves prior to disbudding: a comparison with the intravenous route. Vet Anaesth Analg 41: 372-377.  DOI: 10.1111/vaa.12150

• Salla K, Bennett RC, Restitutti F, Junnila J, Raekallio M, Vainio O. 2014. A comparison in dogs of medetomidine, with or without MK-467, and the combination acepromazine-butorphanol as premedication prior to anaesthesia induced by propofol and maintained with isoflurane. Vet Anaesth Analg 41: 163-73. DOI: 10.1111/vaa.12094

• Viitasaari E, Hänninen L, Heinonen M, Raekallio M, Orro T, Peltoniemi O, Valros A. 2013. Effects of post-partum administration of ketoprofen on sow health and piglet growth. Vet J 198: 153-157. DOI: 10.1016/j.tvjl.2013.06.013 http://www.sciencedirect.com/science/article/pii/S1090023313002979

• Restitutti F, Laitinen MR, Raekallio MR, Vainionpää M, O’Brien RT, Kuusela E, Vainio OM. 2013. Effect of MK-467 on organ blood flow parameters detected by contrast-enhanced ultrasound in dogs treated with dexmedetomidine. Vet Anaesth Analg 40: e48-56. DOI: 10.1111/vaa.12058 http://onlinelibrary.wiley.com/doi/10.1111/vaa.12058/full

• Vainionpää MH, Raekallio MR, Pakkanen SAE, Ranta-Panula V, Rinne VM, Scheinin M, Vainio OM. 2013. Plasma drug concentrations and clinical effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in horses sedated with detomidine. Vet Anaesth Analg 40: 257-264. DOI: 10.1111/vaa.12012 http://onlinelibrary.wiley.com/doi/10.1111/vaa.12012/full

• Vainionpää M, Salla K, Restitutti F, Raekallio M, Junnila J, Snellman M, Vainio O. 2013. Thermographic imaging of superficial temperature in dogs sedated with medetomidine and butorphanol with and without MK-467 (L-659'066). Vet Anaesth Analg 40: 142-148. DOI:10.1111/j.1467-2995.2012.00768.x  http://onlinelibrary.wiley.com/doi/10.1111/j.1467-2995.2012.00768.x/full

• Restitutti F, Raekallio M, Vainionpää M, Kuusela E, Vainio O. 2012. Plasma glucose, insulin, free fatty acids, lactate and cortisol concentrations in dexmedetomidine-sedated dogs with or without MK-467, a peripheral alpha-2 adrenoceptor antagonist. Vet J 193: 481-485. DOI: 10.1016/j.tvjl.2011.12.010 http://www.sciencedirect.com/science/article/pii/S1090023311004898

• Vainionpää MH, Raekallio MR, Junnila JJT, Hielm-Björkman AK, Snellman MPM, Vainio OM. 2012. A comparison of thermographic imaging, physical examination, and modified questionnaire as an instrument to assess painful conditions in cats. J Feline Med Surg 15: 124-131. DOI: 10.1177/1098612X12463926

• Mustonen K, Banting A, Raekallio M, Heinonen M, Peltoniemi OA, Vainio O. 2012. Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin. Vet Rec 171:70. DOI: 10.1136/vr.100431

• Mustonen K, Niemi A, Raekallio M, Heinonen M, Peltoniemi O, Palviainen M, Siven M, Peltoniemi M, Vainio O. 2012. Enantiospecific ketoprofen concentrations in plasma after oral and intramuscular administration in growing pigs. Acta Vet Scand 54:55. DOI: 10.1186/1751-0147-54-55

• Palviainen M, Raekallio M, Rajamäki M, Linden J, Vainio O. 2012. Kidney-derived proteins in urine as biomarkers of induced acute kidney injury in sheep. (Short communication) Vet J 193: 287-289. DOI: 10.1016/j.tvjl.2011.10.004

• Honkavaara J, Restitutti F, Salla K, Raekallio M, Kuusela E, Ranta-Panula V, Rinne V, Vainio O, Scheinin M. 2012. Influence of MK-467, a peripherally acting α2-adrenoceptor antagonist on the disposition of intravenous dexmedetomidine in dogs. Drug Metab Dispos 40: 445-449. DOI: 10.1124/dmd.111.042671 http://dmd.aspetjournals.org/content/40/3/445.short

• Leinonen MR, Raekallio MR, Vainio OM, O’Brien RT. 2011. Effect of anesthesia on contrast-enhanced ultrasound of the feline spleen. Vet J 190: 273-277. DOI: 10.1016/j.tvjl.2010.10.013

• Mustonen K, Ala-Kurikka E, Orro T, Peltoniemi O, Raekallio M, Vainio O, Heinonen M. 2011. Oral ketoprofen is effective in treating non-infectious lameness in sows. Vet J 190: 55-59. DOI: 10.1016/j.tvjl.2010.09.017 http://www.sciencedirect.com/science/article/pii/S1090023310003084

• Honkavaara JM, Restitutti FC, Raekallio MR, Kuusela EK, Vainio OM. 2011. The effects of increasing doses of MK-467, a peripheral alpha2-adrenergic receptor antagonist, on the cardiopulmonary effects of intravenous dexmedetomidine in conscious dogs. J Vet Pharmacol Therap 34: 332-337. DOI: 10.1111/j.1365-2885.2010.01242.x http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2010.01242.x/full

• Restitutti F, Honkavaara JM, Raekallio MR, Kuusela EK, Vainio OM. 2011. Effects of different doses of L-659’066 on the bispectral index and clinical sedation in dogs treated with dexmedetomidine. Vet Anaesth Analg 38: 415–422. DOI: 10.1111/j.1467-2995.2011.00630.x http://onlinelibrary.wiley.com/doi/10.1111/j.1467-2995.2011.00630.x/full

• Leinonen MR, Raekallio MR, Vainio OM, Ruohoniemi MO, O’Brien RT. 2010. The effect of the sample size and location on contrast ultrasound measurement of perfusion parameters. Vet Radiol Ultrasound 52: 82-87. DOI: 10.1111/j.1740-8261.2010.01745.x

• Raekallio MR, Honkavaara JM, Vainio OM. 2010. The effects of L-659,066, a peripheral α2-adrenoceptor antagonist, and verapamil on the cardiovascular influences of dexmedetomidine in conscious sheep. J Vet Pharmacol Therap 33: 434–438. DOI: 10.1111/j.1365-2885.2009.01156.x

• Raekallio MR, Saario-Paunio EMK, Rajamäki MM, Sankari S, Palviainen M, Siven MS, Peltoniemi M, Leinonen M-E, Honkavaara JM, Vainio OM. 2010. Early detection of ketoprofen-induced acute kidney injury by urinary enzyme activities in sheep. Am J Vet Res 71: 1246–1252. DOI: 10.2460/ajvr.71.10.1246

• Niinistö KE, Korolainen RV, Raekallio MR, Mykkänen AK, Koho NM, Ruohoniemi MO, Leppäluoto J, Pösö AR. 2010. Plasma levels of heat shock protein 72 (HSP72) and β-endorphin as indicators of stress, pain and prognosis in horses with colic. Vet J 184: 100-104. DOI: 10.1016/j.tvjl.2009.01.011

• Raekallio MR, Räihä MP, Alanen MH, Sarén NM, Tuovio TA. 2009. Effects of medetomidine, l-methadone, and their combination on arterial oxygenation in dogs. Short communication. Vet Anaesth Analg 36: 158-161. DOI: 10.1111/j.1467-2995.2008.00444.x

• Heinonen ML, Raekallio MR, Oliviero C, Ahokas S Peltoniemi OAT. 2009. Comparison of azaperone-detomidine-butorphanol-ketamine and azaperone-tiletamine-zolazepam for field anaesthesia in pigs. Vet Anaesth Analg 36: 151-157. DOI: 10.1111/j.1467-2995.2008.00443.x

• Koho NM, Raekallio MR, Kuusela E, Vuolle J, Pösö AR. 2008. Lactate transport in canine red blood cells. Am J Vet Res 69: 1091-1096. DOI: 10.2460/ajvr.69.8.1091

• Honkavaara J,  Raekallio M, Kuusela E, Hyvärinen E, Vainio O. 2008. The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs. Vet Anaesth Analg 35: 409-411. DOI: 10.1111/j.1467-2995.2008.00403.x

• Raekallio MR, Mustonen K, Heinonen ML, Peltoniemi OAT, Säkkinen MS, Peltoniemi SM, Honkavaara JM, Vainio OM. 2008. Evaluation of bioequivalence after oral, intramuscular, and intravenous administration of racemic ketoprofen in pigs. Am J Vet Res 69: 108-113. DOI: 10.2460/ajvr.69.1.108

• Raekallio MR, Honkavaara JM, Säkkinen M, Peltoniemi M. 2007. Effects of urine alkalization and activated charcoal on the pharmacokinetics of orally administered carprofen in dogs. Am J Vet Res 68: 423-427. DOI: 10.2460/ajvr.68.4.423

• Raekallio MR, Hielm-Björkman AK, Kejonen J, Salonen HM, Sankari SM. 2006. Evaluation of adverse effects of long-term orally administered carprofen in dogs. J Am Vet Med Assoc 228: 876–880. DOI: 10.2460/ajvr.68.3.258

• Pascoe PJ, Raekallio M, Kuusela E, McKusick B, Granholm M. 2006. Changes in the minimum alveolar concentration of isoflurane and some cardiopulmonary measurements during three continuous infusion rates of dexmedetomidine in dogs. Vet Anaesth Analg 33: 97-103. DOI: 10.1111/j.1467-2995.2005.00236.x

• Väisänen M, Vainio O, Raekallio M, Hietanen H, Huikuri H. 2005. Results of 24-hour ambulatory electro¬cardio-graphy in dogs undergoing ovariohysterectomy following premedication with medetomidine or acepromazine. J Am Vet Med Assoc 226: 738-745.

• Väisänen MA-M, Valros AE, Hakaoja E, Raekallio MR, Vainio OM. 2005. Preoperative stress in dogs - a preliminary investigation of behavior and heart rate variability in healthy hospitalized canine patients. Vet Anaesth Analg 32: 158-167. DOI: 10.1111/j.1467-2995.2005.00188.x

• Raekallio M, Kuusela E, Lehtinen M.E, Tykkyläinen M, Huttunen P, Westerholm F. 2005. Effects of exercise-induced stress and dexamethasone on plasma hormone and glucose concentrations and sedation in dogs treated with dexmedetomidine. Am J Vet Res 66: 60-65.

• Väisänen M, Lilius E-M, Mustonen L, Raekallio M, Kuusela E, Koivisto M, Vainio O. 2004. Effects of Ovariohysterectomy on Canine Blood Neutrophil Respiratory Burst: a Chemiluminescence Study. Vet Surg 33: 551-556. DOI: 10.1111/j.1532-950X.2004.04077.x

• Hielm-Björkman A, Kuusela E, Liman A, Markkola A, Saarto E, Huttunen P, Leppäluoto J, Tulamo R-M, Raekallio M. 2003. Evaluation of methods for assessment of pain associated with chronic osteoarthritis in dogs. J Am Vet Med Assoc 222: 1552-1558.

• Kuusela E, Vainio O, Short CE, Leppäluoto J, Huttunen P, Ström S, Huju V, Valtonen A, Raekallio M. 2003. A comparison of propofol infusion and propofol/isoflurane anaesthesia in dexmedetomidine premedicated dogs. J Vet Pharmacol Therap 26: 1-6.

• Raekallio M, Heinonen KM, Kuussaari J, Vainio O. 2003. Pain alleviation in animals: Attitudes and practices of Finnish veterinarians. Vet J 165: 131-135.

• Väisänen M, Raekallio M, Kuusela E, Huttunen P, Leppäluoto J, Kirves P, Vainio O. 2002. Evaluation of the perioperative stress response in dogs administered medetomidine or acepromazine as part of the preanesthetic medication. Am J Vet Res 63: 969-975.

• Kuusela E, Raekallio M, Hietanen H, Huttula J, Vainio O. 2002. 24-hour Holter-monitoring in the perianaesthetic period in dogs premedicated with dexmedetomidine. Vet J 164: 235-239 DOI:10.1053/tvjl.2002.0735.

• Ansah OB, Raekallio M, Hellsten C, Vainio O. 2002. Postoperative pain control in cats: clinical trials with medetomidine and butorphanol. Vet Surg 31: 99-103. DOI: 10.1053/jvet.2002.31047

• Raekallio M, Ansah OB, Kuusela E, Vainio O. 2002. Some factors influencing the level of clinical sedation induced by medetomidine in rabbits. J Vet Pharmacol Therap 25: 39-42. DOI: 10.1046/j.1365-2885.2002.00382.x

• Kuusela E, Raekallio M, Väisänen M, Mykkänen K, Ropponen H, Vainio O. 2001. Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofol-isoflurane anesthesia. Am J Vet Res 62: 1073-1080

• Kuusela E, Vainio O, Kaistinen A, Kobylin S, Raekallio M. 2001. Sedative, analgesic, and cardiovascular effects of levomedetomidine alone and in combination with dexmedetomidine in dogs. Am J Vet Res 62: 616-621.

• Hielm-Björkman A, Raekallio M, Tulamo R-M, Kuusela E, Saarto E, Markkola A. 2001. Double-blind evaluation of implants of gold wire at acupuncture points in the dog as a treatment for osteoarthritis induced by hip dysplasia. Vet Rec 149: 452-456. DOI:10.1136/vr.149.15.452

• Kuusela E, Raekallio M, Anttila M, Falck I, Mölsä S, Vainio O. 2000. Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs. J Vet Pharmacol Therap 23: 15-20. DOI: 10.1046/j.1365-2885.2000.00245.x

• Ansah OB, Raekallio M, Vainio O. 2000. Correlation between serum concentration following continuous intravenous infusion of dexmedetomidine or medetomidine in cats and their sedative and analgesic effects. J Vet Pharmacol Therap 23: 1-8. DOI: 10.1046/j.1365-2885.2000.00240.x

Conference presentations and posters (since 2015)

• Adam M, Huuskonen V, Raekallio MR, Casoni D, Mykkänen AK, Lappalainen AK, Vainio O. Haemodynamic effects of MK-467, a peripherally acting alpha2-adrenoceptor antagonist, in sevoflurane-anaesthetized sheep receiving dexmedetomidine. Association of Veterinary Anaesthetists Autumn Meeting, Berlin, 9-12.11.2017.

• Huuskonen V, Adam M, Raekallio MR, Mykkänen AK, Casoni D, Lappalainen AK, Vainio O. MK-467, a peripherally acting alpha2-adrenoceptor antagonist, alleviates dexmedetomidine-induced pulmonary changes in sevoflurane-anaesthetised sheep. Association of Veterinary Anaesthetists Autumn Meeting, Berlin, 9-12.11.2017.

• Turunen H, Raekallio MR, Adam M, Helin H, Nevanperä K, Kallio-Kujala IJ, Honkavaara MJ, Restitutti F, Larenza Menzies MP, Vainio O. The effects of MK-467, a peripheral α₂-adrenergic receptor antagonist, on the plasma drug concentrations and sedation in dogs receiving atipamezole to reverse medetomidine-induced sedation. Association of Veterinary Anaesthetists Autumn Meeting, Berlin, 9-12.11.2017.

• Kallio-Kujala IJ, Turunen HM, Raekallio MR, Honkavaara J, Salla K, Casoni D, Hautajärvi H, Vainio O. Intramuscular use of a peripherally acting alpha2-adrenoceptor antagonist MK-467 with medetomidine and butorphanol in dogs – a prospective, randomized clinical trial. Association of Veterinary Anaesthetists Autumn Meeting, Berlin, 9-12.11.2017.

• Tapio H, Raekallio M, Mykkänen A, Mama K, Mendez Angulo JL, Hautajärvi H, Vainio O. Effects of MK-467 and hyoscine on cardiovascular and gastrointestinal changes induced by detomidine in horses. Annual Scientific Meeting of ECVS (European College of Veterinary Surgeons),  Edinburgh, UK, 13.-15.7.2017. (poster)

• Keskitalo TK, Adam M, Raekallio MR, Vainio OM. Cardiopulmonary effects of the peripheral α2-adrenoseptor antagonist MK-467 in medetomidine sedated sheep receiving atipamezole. Association of Veterinary Anaesthetists Spring Meeting, Manchester, UK, 27.-28.4.2017.

• Adam M, Keskitalo TK, Raekallio MR, Vainio OM. Cardiovascular and sedative effects of MK-467, a peripheral alpha2-adrenoceptor antagonist, in sheep sedated with intramuscular medetomidine. Association of Veterinary Anaesthetists Spring Meeting, Manchester, UK, 27.-28.4.2017.

• Kallio-Kujala I, Raekallio M, Honkavaara J, Bennett RC, Turunen H, Vainio O. MK-467 accelerates the absorption of sedative agents in dogs – preliminary results. Association of Veterinary Anaesthetists Spring Meeting, Manchester, UK, 27.-28.4.2017. (poster)

• Adam M, Salla K, Raekallio M, Honkavaara J, Mölsä S, Vainio O. Cardiopulmonary effects of MK-467, a peripheral alpha2-adrenoceptor antagonist, in sheep receiving medetomidine-ketamine. Association of Veterinary Anaesthetists Autumn Meeting, Prague, Czech Republic, 14-17.9.2016.

• Pakkanen S, de Vries A, Raekallio M, Palviainen M, Vainio O. The effect of romifidine, MK-467, a peripheral alpha-2-adrenoceptor antagonist, and their combination on plasma glucose concentration in horses. Association of Veterinary Anaesthetists Autumn Meeting, Prague, Czech Republic, 14-17.9.2016.

• Kaartinen MJ, Pelligand L, Restitutti F, Raekallio MR, Scheinin M, Vainio OM. 2016. Pharmacokinetic interaction of three doses of the peripheral alpha-2 antagonist MK-467 on the disposition of intramuscular medetomidine in dogs. Association of Veterinary Anaesthetists Spring Meeting, Lyon, France, 20-22.4.2016.

• Salla K,  Tuns C, Junnila J, Raekallio M, Vainio O. 2016. Cardiovascular effects of the alpha-2-adrenoceptor antagonist MK-467 compared to glycopyrrolate during isoflurane anaesthesia in dogs premedicated with medetomidine. Association of Veterinary Anaesthetists Spring Meeting, Lyon, France, 20-22.4.2016.

• Koskinen H, Raekallio M, Rajamäki M, Tapio H, Mykkänen A. 2015. Effects of general anaesthesia in dorsal recumbency to bronchoalveolar lavage cytology of healthy horses. Veterinary Comparative Respiratory Society, Edinburgh, UK, 8-10.10.2015

• Hector RC, Rezende M, Mama K, Steffey EP, Bunnag N, Honkavaara J, Raekallio M, Vainio O. 2015. The effects of dexmedetomidine and MK-467 on the minimum alveolar concentration of sevoflurane in dogs. American College of Veterinary Anesthesia and Analgesia Annual Meeting. Washington DC, USA, 19.9.2015.

• Restitutti F, Raekallio M, Kaartinen J, Honkavaara J, Wejberg O, Mikkola E, Scheinin M, Vainio O. 2015. Influence of MK-467 on the absorption of medetomidine after intramuscular administration in dogs – Preliminary results. 12th World Congress of Veterinary Anaesthesiology, Kyoto, Japan, 1-4.9.2015.

• Mama K, Rezende M, Steffey EP, Hector RC, Bunnag N, Honkavaara J, Raekallio M, Vainio O. 2015. Effect of two doses of the peripheral alpha-2-adrenoceptor antagonist MK-467 on the minimum alveolar concentration (MAC) of sevoflurane in dogs receiving dexmedetomidine. 12th World Congress of Veterinary Anaesthesiology, Kyoto, Japan, 1-4.9.2015.

• Restitutti F, Kaartinen J, Raekallio M, Wejberg O, Mikkola E, Honkavaara J, Vainio O. 2015. Cardiovascular and sedative effects of intramuscular co-administration of medetomidine and MK-467, a peripheral alpha-2-adrenoceptor antagonist, in dogs – Preliminary results. 12th World Congress of Veterinary Anaesthesiology, Kyoto, Japan, 1-4.9.2015.

• Turunen H, Raekallio M, Adam M, Helin H, Nevanperä K, Kallio-Kujala I, Honkavaara J, Restitutti F, Larenza P, Vainio O. 2015. The effects of MK-467, a peripheral α₂-adrenergic receptor antagonist, on the cardiovascular system and sedation in dogs receiving atipamezole to reverse medetomidine-induced sedation. 12th World Congress of Veterinary Anaesthesiology, Kyoto, Japan, 1-4.9.2015.

• Restitutti F, Honkavaara J, Menzies RA, Rosati T, Vainio O, Raekallio M, Larenza Menzies MP. 2015. Influence of acepromazine and/or a constant rate infusion of MK-467 on cardiovascular parameters of dogs anaesthetized with isoflurane and a step up infusion of dexmedetomidine – Preliminary data. 12th World Congress of Veterinary Anaesthesiology, Kyoto, Japan, 1-4.9.2015.

• Mama K, Rezende M, Steffey EP, Hector RC, Bunnag N, Honkavaara J, Raekallio M, Vainio O. 2015. Cardiovascular effects of dexmedetomidine alone and in combination with two doses of the peripheral α-2-adrenoceptor antagonist MK-467 in sevoflurane anesthetized dogs. 12th World Congress of Veterinary Anaesthesiology, Kyoto, Japan, 1-4.9.2015.

• Huuskonen V, Restitutti F, Honkavaara J, Raekallio M, Bennett R, Hagman M, Vainio O. 2015. The cardiovascular effects of dobutamine in isoflurane-anaesthetised dogs treated with dexmedetomidine and MK-467, a peripheral α2-antagonist. 12th World Congress of Veterinary Anaesthesiology, Kyoto, Japan, 1-4.9.2015.

• Kallio-Kujala I, Bennett RC, Raekallio M, Yatkin E, Scheinin M, Spillmann T, Vainio O. 2015. The effects of dexmedetomidine, a peripherally acting α2-antagonist (MK-467) and glibenclamide on blood glucose and lactate concentrations in dogs – Preliminary results. 12th World Congress of Veterinary Anaesthesiology, Kyoto, Japan, 1-4.9.2015. 190. (Poster)

Salla K. 2017. Haemodynamic effects of MK-467 in combination with medetomidine and selected sedative and anaesthetic agents in dogs. ISBN:978-951-51-3860-6

Bennett R. 2017. The Impact of MK-467 on certain Pharmacokinetic and Pharmacodynamic Properties of Selected Drugs affecting the Central Nervous System in Dogs. ISBN:978-951-51-3509-4

Kaartinen J. 2016. The haemodynamic and pharmacologic interaction of medetomidine and peripheral antagonist MK-467 and their dose-dependency in dogs. ISBN:978-951-51-2460-9

Restitutti F. 2015. Central, cardiovascular and metabolic effects of dexmedetomidine associated with the selective peripheral alpha2-adrenoceptor antagonist MK-467 in dogs. ISBN:978-951-51-1735-9

Vainionpää M. 2014. Thermographic imaging in cats and dogs: usability as a clinical method. University of Helsinki. ISBN:978-952-10-9942-7

Hemmann K. 2014. Crib-biting in Horses: A Physiological and Genetic Study of Candidate Causative Factors. University of Helsinki. ISBN:978-952-9991-5

Palviainen M. 2014. Potential urinary biomarkers of acute kidney injury in domestic animals. University of Helsinki. ISBN:978-952-10-9797-3

Honkavaara J. 2012. Dexmedetomidine and MK-467, a peripherally acting α2-adrenoceptor antagonist, in dogs. University of Helsinki. ISBN:978-952-10-7744-9

Mustonen K. 2012. Pharmacology of ketoprofen administered orally to pigs: an experimental and clinical study. ISBN:978-952-10-8378-5

Thomson K. 2010. Species-specific and Indication-based Use of Antimicrobials in Dogs, Cats, Cattle and Horses in Finland : Data collected using three different methods. ISBN:978-952-10-6714-3

Väisänen M. 2006. Perioperative stress in dogs – different aspects of manifestation and characteristics with medetomidine and acepromazine preanaesthetic medication. ISBN:952-10-2975-7

Kuusela E. 2004. Dexmedetomidine and levomedetomidine, the isomers of medetomidine, in dogs. ISBN:952-10-1675-2

Osei A. 2004. Use of the alpha-2-adrenoceptor agonists, medetomidine and dexmedetomidine in the sedation and analgesia of domestic cats. ISBN:952-10-1908-5

Cognition and behavior related

Myller, A. (in preparation) Canine vision. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. Supervisor H. Törnqvist, supervising professor O. Vainio.

Inkinen L. (in preparation). Activity trackers in evaluating the connection of dog mobility and cognitive behaviour. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. Supervisor PhD M. Kujala, supervising professor O.Vainio

Koskela A. 2016. The evolutionary background of mammalian emotions and the measurement of them. Masters thesis in biology, Faculty of Biolocigal and Enviromental Sciences, University of Helsinki. Supervisors MSc S.Somppi and MSc H.Telkänranta, supervising professor H.Pietiäinen

Tammela T. 2014. Brain basis of canine sensory processing. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. Supervisor PhD M. Kujala, supervising professor O.Vainio (in Finnish)

Kukkola L. 2013. Environmental effects on social cognition of domestic dogs. Masters thesis in psychology, Faculty of Social Sciences, University of Göteborg. Supervisor MSc H. Törnqvist, supervising professor S. Hansen

Malkamäki S. 2012. The behavioral charasteristics of Finnish rottweiler dogs. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. Supervisors MCs S.Somppi, supervising professor A.Valros (in Finnish)

Valkonen M. 2012. The heritability of aggressiveness and fearfullness of Finnish rottweiler dogs. Masters thesis in animal science, Faculty of Agriculture and Forestry, University of Helsinki. Supervisors MSc S.Somppi, supervising professor J. Juga (in Finnish)

Haukka T. 2012. Dog emotions and personality of dogs from the owners point of view. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. Supervisors MSc S.Somppi, supervising professor A.Valros

Törnqvist H. 2011. The application of eye tracker in dog cognition studies. Masters Thesis in cognition, Faculty of Behavioural Sciences, University of Helsinki. Supervisors MSc S.Somppi, supervising professor C.M. Krause

Pain and pharmacology related (excerpts since 2015)

Hepolehto E. 2016. The use of immunosuppressive drugs in dogs and cats - a literature review. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. Supervisor Marja Raekallio, supervising professor Outi Vainio. (in Finnish)

Virtanen M. 2015. Alpha-2-agonists side effects in cats. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. (in Finnish)

Mikkola E. 2015. The effects of a combination of medetomidine and MK-467 on cardiovascular parameters in dogs. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. (in Finnish)

Wejberg O. 2015. The effects of the medetomidine and MK-467 on sedation and respiratory parameters. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. (in Finnish)

Huttunen A. 2015. Chronic pain physiology and drug therapy in dogs and cats. Licenciate thesis, Faculty of Veterinary Medicine, University of Helsinki. Supervisor Marja Raekallio, supervising professor Outi Vainio. (in Finnish)