Research

The specialisation options of the programme – Neuroscience and psychobiology, Cancer, Regenerative medicine, Metabolic disorders, and Cross-disciplinary translational medicine – are closely aligned with the research focus areas of the Faculty of Medicine. You therefore have an opportunity to learn from, and be supervised by, the leading experts and professors in their fields.

TRANSMED students are enrolled in the research groups for learning current research methdos and for their master's thesis work. Below are examples of scientific publications to which TRANSMED students have contributed during their studies.

2018

S Gramolelli, J Cheng, I Martinez-Corral, M Vähä-Koskela, E Elbasani, E Kaivanto, V Rantanen, K Tuohinto, S Hautaniemi, M Bower, C Haglund, K Alitalo, T Mäkinen, TV Petrova, K Lehti and PM. Ojala. PROX1 is a transcriptional regulator of MMP14. Scientific Reports 2018 Jun 22;8(1):9531.

Hulmi JJ, Nissinen TA, Räsänen M, Degerman J, Lautaoja JH, Hemanthakumar KA, Backman JT, Ritvos O, Silvennoinen M, Kivelä R. Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle. J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):417-432. doi: 10.1002/jcsm.12265. Epub 2017 Dec 11.

Tang J, Tanoli ZU, Ravikumar B, Alam Z, Rebane A, Vähä-Koskela M, Peddinti G, van Adrichem AJ, Wakkinen J, Jaiswal A, Karjalainen E, Gautam P, He L, Parri E, Khan S, Gupta A, Ali M, Yetukuri L, Gustavsson AL, Seashore-Ludlow B, Hersey A, Leach AR, Overington JP, Repasky G, Wennerberg K, Aittokallio T. Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions. Cell Chem Biol. 2018 Feb 15;25(2):224-229.e2. doi: 10.1016/j.chembiol.2017.11.009. Epub 2017 Dec 21.

2017

Al-Samadi A, Awad SA, Tuomainen K, Zhao Y, Salem A, Parikka M, Salo T. Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models. Oncotarget. 2017 May 10;8(36):60123-60134. doi:10.18632/oncotarget.17768. eCollection 2017 Sep 1.

Korpi ER, Linden AM, Hytönen HR, Paasikoski N, Vashchinkina E, Dudek M, Herr DR, Hyytiä P. Continuous delivery of naltrexone and nalmefene leads to tolerance in reducing alcohol drinking and to supersensitivity of brain opioid receptors. Addict Biol. 2017 Jul;22(4):1022-1035. doi:10.1111/adb.12393. Epub 2016 Mar 15.

Sulkava S, Ollila HM, Alasaari J, Puttonen S, Härmä M, Viitasalo K, Lahtinen A, Lindström J, Toivola A, Sulkava R, Kivimäki M, Vahtera J, Partonen T, Silander K, Porkka-Heiskanen T, Paunio T. Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers. Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw011.

2016 Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K. VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13144-13149. Epub 2016 Oct 31.
  Nissinen TA, Degerman J, Räsänen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, Kivelä R, Hulmi JJ. Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep. 2016 Sep 26;6:32695. doi: 10.1038/srep32695.
  Fu Y, Gaelings L, Söderholm S, Belanov S, Nandania J, Nyman TA, Matikainen S, Anders S, Velagapudi V, Kainov DE.JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res. 2016.133:23-31. doi:10.1016/j.antiviral.2016.07.008. [Epub ahead of print]
  S Fang, H Nurmi, K Heinolainen, S Chen, E Salminen, P Saharinen, H K A Mikkola, K Alitalo. Critical requirement of VEGF-C in transition to fetal erythropoiesis. Blood 2016 128:710-720 doi:10.1182/blood-2015-12-687970
2015 Al-Samadi A, Drozd A, Salem A, Hietanen J, Häyrinen-Immonen R, Konttinen YT. Epithelial Cell Apoptosis in Recurrent Aphthous Ulcers. J Dent Res. 2015 Apr 10. pii: 0022034515581012. [Epub ahead of print]
  Marques E, Englund JI, Tervonen TA, Virkunen E, Laakso M, Myllynen M, Mäkelä A, Ahvenainen M, Lepikhova T, Monni O, Hautaniemi S, Klefström J. Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers. Oncogene. 2015 Jun 15. doi: 10.1038/onc.2015.196.
2014 Rantanen V, Valori M, Hautaniemi S. Anima: modular workflow system for comprehensive image data analysis. Front Bioeng Biotechnol. 2014 Jul 30;2:25. doi: 10.3389/fbioe.2014.00025. eCollection 2014.
  Lakspere T, Kallio-Kokko H, Kantele A, Mattila P, Almusa H, Kainov D, Kakkola L. Full-Genome Sequences of Influenza H3N2 Virus Strains Isolated from Finnish Patients during the 2012-2013 Epidemic Season. Genome Announc. 2014 Mar 27;2(2). pii: e00039-14.
  Paananen RO, Rantamäki AH, Holopainen JM. Antievaporative Mechanism of Wax Esters: Implications for the Function of Tear Fluid. Langmuir. 2014 May 12. [Epub ahead of print]