Professor, MD, PhD

 Research interest

  • Cell surface carbohydrates: Cell surface carbohydrates are important mediators of the interactions of cells and the external world. They are also involved in the pathogenesis of maladies such as cancer and bacterial diseases.

Jukka Finne online

Professor

Research interest

  • Our work, which aims at spatial cellular/structural biology, focuses on proteins and
    protein complexes that are at and close to the cell surface, looking at neuronal protein interactions (e.g. GDNF-GFRα-RET and MANF),  at host-pathogen interactions,
    such as those involving trimeric autotransporters, factor H and complement, and membrane integral pumps. Read more

Adrian Goldman online

PhD, Group leader: Hietakangas lab

Research interest

  • Hietakangas lab: Our group studies nutrient sensing in animals. We aim to understand how nutrients regulate gene expression and signalling to adjust metabolism and growth. Our main experimental approaches include Drosophila genetics and genomics.

Ville Hietakangas online

 

Professor

Research interest

  • Bioinformatics: The group's main interests are protein sequence-structure-function relationships and computational analysis of gene regulation.

 

Liisa Holm online

 

Associate Professor

Research interest

  • Genetic and neurobiological basis of anxiety disorders: Our aim is to identify genetic factors that regulate anxiety. We use functional genomics approaches to identify gene regulatory networks involved in the regulation of anxiety, investigate the mechanisms of affected genes and miRNAs, and study them as candidate genes for human anxiety disorders.

 

Iiris Hovatta online

 

Professor

Research interest

  • AMPA Receptors: We wish to understand at molecular level how the structure and molecular interactions of AMPA receptors, a major subclass of glutamate-gated ion channels, relate to their central role in excitatory synaptic neurotransmission.

Kari Keinänen online

Professor in Quantitative Cell Biology
 
Research interest
 
  • Actin cytoskeleton and plasma membrane dynamics: We use a large array of biophysical, biochemical, and cell biological approaches to understand how dynamics of the actin cytoskeleton are regulated in cells. Moreover, we examine interplay between the actin cytoskeleton and plasma membrane in various processes, including cell migration and morphogenesis.
 

Pekka Lappalainen online

Research director

Research interest

  • Epithelial morphogenesis – from molecular pathways to cellular behavior: One of the big questions in developmental biology is how cells of the embryo get organized into tissues and organs. We use mouse as a model organism, the hair follicle and mammary gland as model organs and combine in vivo, ex vivo organ culture, as well as a battery of molecular and cell biology techniques including live-imaging of developing organs to answer these questions.

 

Marja Mikkola online

Professor

Research interest

  • DNA mismatch repair and cancer: The object of the project is functionally characterize genetic and epigenetic changes associated with risk of colorectal cancer. Using in vitro and in vivo models, we address pathogenic and functional significance of inherited DNA mismatch repair gene mutations found in cancer patients as well as epigenetic alterations in normal mucosa involved in colorectal cancer risk and initiation.

Minna Nyström online

University lecturer

Research interest

The aim of the Project is to sequence ancient Finnish and Fenno-Ugrian human remains. Both whole genomic, as well as more traditional maternal and paternal lineages will be compared to both current Finns, the neigbouring populations, as well as other Fenno-Ugric people. The ultimate goal is to find how and when the "present-day Finnish" population has emerged: the migrations, admixtures etc. Which archeological cultures brought which component, if that can be determined?

Onkamo Research Group in Tuhat research database

 

Päivi Onkamo online

Tenure Track Group Leader

Research interest

  • A broad interest of our research is to gain a mechanistic understanding of the functioning of complex cellular machineries that are responsible for eukaryotic proteome maintenance. In particular, we use potent natural product small molecules as pharmacological probes for different proteostatic processes and explore their therapeutic potential for diseases that have developed an over-reliance on protein homeostasis. Our work combines aspects of chemical and structural biology with biochemistry and eukaryotic genomic methods.
  • Paavilainen lab

 

Ville Paavilainen online

Professor

Research interest

  • Regulation of neuronal differentiation in the embryonic midbrain: Our group is interested in how neuronal diversity is generated during embryonic development. In particular, we study the mechanisms of intercellular communication and gene regulation, which control neuronal differentiation in a distinct region of the vertebrate brain -  the midbrain.

Juha Partanen online

University lecturer, docent 

Research interest

  • Molecular genetics and pathogenesis of nemaline myopathy and related muscle disorders: The aim of our research is to improve molecular genetic diagnostics of nemaline myopathy and related muscle disorders caused by mutations in genes encoding components of the skeletal muscle sarcomere, and to gain understanding of the molecular mechanisms leading from mutation to disease phenotype.

Katarina Pelin online

 

Docent

Research interest

  • Inner ear sensory cell biology: Our group focuses on the sensory receptor cells of the hearing and balance organs. We study molecular regulation of development and death of these cells and their regeneration capacity. The goal of our developmental and cell biological research is to design biological interventions to treat hearing impairment.

Ulla Pirvola online

Doctoral Programme Coordinator, PhD

  • Doctoral school in Health Sciences
  • Doctoral programme in Integrative Life Science (ILS)

Group leader, PhD, docent

Research interests

  • Organization of the cell nucleus: the cell nucleus is highly compartmentalized organelle, but the mechanisms that mediate especially the dynamic changes in nuclear organization are still poorly understood. We study especially the role of actin in the cell nucleus by using cell and molecular biology techniques as well as functional genomics and advanced microscopy methods

Maria Vartiainen online