Publications

Tile image of leaf spores at 20x

List of publications where BIU facilities were utilized. Please note that if you have used BIU equipment or other services for your publication, you are expected to acknowledge BIU in your article and inform us about your publication.

Achuta, V.S., Grym, H., Putkonen, N., Louhivuori, V., Karkkainen, V., Koistinaho, J., Roybon, L., Castren, M.L. Metabotropic Glutamate Receptor 5 Responses Dictate Differentiation of Neural Progenitors to NMDA-Responsive Cells in Fragile X Syndrome. Developmental Neurobiology. 2017; 77:438-53.

Antila, S., Karaman, S., Nurmi, H., Airavaara, M., Voutilainen, M.H., Mathivet, T., Chilov, D., Li, Z.L., Koppinen, T., Park, J.H., Fang, S., Aspelund, A., Saarma, M., Eichmann, A., Thomas, J.L., Alitalo, K. Development and plasticity of meningeal lymphatic vessels. Journal of Experimental Medicine. 2017; 214:3645-67.

Back, N., Kanerva, K., Kurutihallib, V., Yanik, A., Ikonen, E., Mains, R.E., Eipper, B.A. The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together. European Journal of Cell Biology. 2017; 96:407-17.

Bjork, S., Ojala, E.A., Nordstrom, T., Ahola, A., Liljestrom, M., Hyttinen, J., Kankuri, E., Mervaala, E. Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes. Frontiers in Physiology. 2017; 8:884.

Chernov, K.G., Neuvonen, M., Brock, I., Ikonen, E., Verkhusha, V.V. Introducing inducible fluorescent split cholesterol oxidase to mammalian cells. Journal of Biological Chemistry. 2017; 292:8811-22.

Dash, S.N., Narumanchi, S., Paavola, J., Perttunen, S., Wang, H., Lakkisto, P., Tikkanen, I., Lehtonen, S. Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish. American Journal of Physiology-Heart and Circulatory Physiology. 2017; 312:H1085-H95.

Dumont, V., Tolvanen, T.A., Kuusela, S., Wang, H., Nyman, T.A., Lindfors, S., Tienari, J., Nisen, H., Suetsugu, S., Plomann, M., Kawachi, H., Lehtonen, S. PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. Faseb Journal. 2017; 31:3978-90.

Faisal, I., Kauppi, L. Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy. Development. 2017; 144:1988-96.

Gateva, G., Kremneva, E., Reindl, T., Kotila, T., Kogan, K., Gressin, L., Gunning, P.W., Manstein, D.J., Michelot, A., Lappalainen, P. Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro. Current Biology. 2017; 27:705-13.

Havunen, R., Siurala, M., Sorsa, S., Gronberg-Vaha-Koskela, S., Behr, M., Tahtinen, S., Santos, J.M., Karell, P., Rusanen, J., Nettelbeck, D.M., Ehrhardt, A., Kanerva, A., Hemminki, A. Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy. Molecular Therapy-Oncolytics. 2017; 4:77-86.

Heikkinen, T., Kampjarvi, K., Keskitalo, S., von Nandelstadh, P., Liu, X., Rantanen, V., Pitkanen, E., Kinnunen, M., Kuusanmaki, H., Kontro, M., Turunen, M., Makinen, N., Taipale, J., Heckman, C., Lehti, K., Mustjoki, S., Varjosalo, M., Vahteristo, P. Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry. Human Mutation. 2017; 38:269-74.

Heinolainen, K., Karaman, S., D'Amico, G., Tammela, T., Sormunen, R., Eklund, L., Alitalo, K., Zarkada, G. VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling. Circulation Research. 2017; 120:1414-+.

Hulmi, J.J., Nissinen, T.A., Räsänen, M., Degerman, J., Lautaoja, J.H., Hemanthakumar, K.A., Backman, J.T., Ritvos, O., Silvennoinen, M., Kivelä, R. Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle. 2017.

Jha, S.K., Rauniyar, K., Karpanen, T., Leppanen, V.M., Brouillard, P., Vikkula, M., Alitalo, K., Jeltsch, M. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. Scientific Reports. 2017; 7:4916.

Kara, B., Koroglu, C., Peltonen, K., Steinberg, R.C., Genc, H.M., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V.M., Ikonen, E., Laiho, M., Tolun, A. Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A. European Journal of Human Genetics. 2017; 25:315-23.

Lampinen, A.M., Virman, J.P., Bono, P., Luukkaala, T.H., Sunela, K.L., Kujala, P.M., Saharinen, P., Kellokumpu-Lehtinen, P.-L.I. Novel Angiogenesis Markers as Long-Term Prognostic Factors in Patients With Renal Cell Cancer. Clinical Genitourinary Cancer. 2017; 15:e15-e24.

Lehtimaki, J.I., Fenix, A.M., Kotila, T.M., Balistreri, G., Paavolainen, L., Varjosalo, M., Burnette, D.T., Lappalainen, P. UNC-45a promotes myosin folding and stress fiber assembly. Journal of Cell Biology. 2017; 216:4053-72.

Leppänen, V.-M., Saharinen, P., Alitalo, K. Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proceedings of the National Academy of Sciences. 2017; 114:4376-81.

Maliniemi, P., Laukkanen, K., Vakeva, L., Dettmer, K., Lipsanen, T., Jeskanen, L., Bessede, A., Oefner, P.J., Kadin, M.E., Ranki, A. Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas. Oncoimmunology. 2017; 6:e1273310.

Markkanen, M., Ludwig, A., Khirug, S., Pryazhnikov, E., Soni, S., Khiroug, L., Delpire, E., Rivera, C., Airaksinen, M.S., Uvarov, P. Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function. Brain Research. 2017; 1675:87-101.

Mikkonen, E., Haglund, C., Holmberg, C.I. Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans. Plos One. 2017; 12:e0183403.

Novakovic, D., Saarinen, J., Rojalin, T., Antikainen, O., Fraser-Miller, S.J., Laaksonen, T., Peltonen, L., Isomaki, A., Strachan, C.J. Multimodal Nonlinear Optical Imaging for Sensitive Detection of Multiple Pharmaceutical Solid-State Forms and Surface Transformations. Analytical Chemistry. 2017; 89:11460-7.

Pfisterer, S.G., Gateva, G., Horvath, P., Pirhonen, J., Salo, V.T., Karhinen, L., Varjosalo, M., Ryhanen, S.J., Lappalainen, P., Ikonen, E. Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage. Nature Communications. 2017; 8:14858.

Redchuk, T.A., Omelina, E.S., Chernov, K.G., Verkhusha, V.V. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nature Chemical Biology. 2017; 13:633-+.

Saarinen, J., Sozeri, E., Fraser-Miller, S.J., Peltonen, L., Santos, H.A., Isomaki, A., Strachan, C.J. Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy. International Journal of Pharmaceutics. 2017; 523:270-80.

Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J.P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, K., Peehl, D.M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Ostling, P., af Hallstrom, T.M. Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer. European Urology. 2017; 71:319-27.

Saurus, P., Tolvanen, T.A., Lindfors, S., Kuusela, S., Holthofer, H., Lehtonen, E., Lehtonen, S. Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis. Scientific Reports. 2017; 7:10731.

Sepponen, K., Lundin, K., Knuus, K., Vayrynen, P., Raivio, T., Tapanainen, J.S., Tuuri, T. The Role of Sequential BMP Signaling in Directing Human Embryonic Stem Cells to Bipotential Gonadal Cells. Journal of Clinical Endocrinology & Metabolism. 2017; 102:4303-14.

Steinzeig, A., Molotkov, D., Castren, E. Chronic imaging through "transparent skull" in mice. Plos One. 2017; 12:e0181788.

Vaahtomeri, K., Karaman, S., Makinen, T., Alitalo, K. Lymphangiogenesis guidance by paracrine and pericellular factors. Genes & Development. 2017; 31:1615-34.

Wasik, A.A., Dumont, V., Tienari, J., Nyman, T.A., Fogarty, C.L., Forsblom, C., Lehto, M., Lehtonen, E., Groop, P.H., Lehtonen, S. Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion. Experimental Cell Research. 2017; 350:336-48.

Yin, M., Tissari, M., Tamminen, J., Ylivinkka, I., Ronty, M., von Nandelstadh, P., Lehti, K., Hyytiainen, M., Myllarniemi, M., Koli, K. Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma. Oncotarget. 2017; 8:98280-97.

Ylivinkka, I., Sihto, H., Tynninen, O., Hu, Y.Z., Laakso, A., Kivisaari, R., Laakkonen, P., Keski-Oja, J., Hyytiainen, M. Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness. Journal of Experimental & Clinical Cancer Research. 2017; 36:9.

Ainola, M., Tomaszewski, W., Ostrowska, B., Wesolowska, E., Wagner, H.D., Swieszkowski, W., Sillat, T., Peltola, E., Konttinen, Y.T. A bioactive hybrid three-dimensional tissue-engineering construct for cartilage repair. Journal of Biomaterials Applications. 2016; 30:873-85.

Backlund, M., Paukku, K., Kontula, K.K., Lehtonen, J.Y. Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism. Nucleic Acids Res. 2016; 44:3095-104.

Balistreri, G., Viiliainen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S., Ojala, P.M. Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication. PLoS Pathog. 2016; 12:e1005424.

Dash, S.N., Hakonen, E., Ustinov, J., Otonkoski, T., Andersson, O., Lehtonen, S. sept7b is required for the differentiation of pancreatic endocrine progenitors. Sci Rep. 2016; 6:24992.

Datta, N., Lindfors, S., Miura, N., Saleem, M.A., Lehtonen, S. Data supporting the regulation of FOXC2 in podocyte dysfunction. Data Brief. 2016; 6:514-20.

Datta, N., Lindfors, S., Miura, N., Saleem, M.A., Lehtonen, S. Overexpression of transcription factor FOXC2 in cultured human podocytes upregulates injury markers and increases motility. Exp Cell Res. 2016; 340:32-42.

Fang, S., Nurmi, H., Heinolainen, K., Chen, S., Salminen, E., Saharinen, P., Mikkola, H.K., Alitalo, K. Critical requirement of VEGF-C in transition to fetal erythropoiesis. Blood. 2016; 128:710-20.

Haikala, H.M., Klefstrom, J., Eilers, M., Wiese, K.E. MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell Cycle. 2016; 15:316-23.

Holtta-Vuori, M., Sezgin, E., Eggeling, C., Ikonen, E. Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation. Traffic. 2016; 17:1054-7.

Jiang, Q., Stamatova, I., Kainulainen, V., Korpela, R., Meurman, J.H. Interactions between Lactobacillus rhamnosus GG and oral micro-organisms in an in vitro biofilm model. BMC Microbiology. 2016; 16:149.

Jokinen, R., Marttinen, P., Stewart, J.B., Neil Dear, T., Battersby, B.J. Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division. Hum Mol Genet. 2016; 25:706-14.

Kampjarvi, K., Kim, N.H., Keskitalo, S., Clark, A.D., von Nandelstadh, P., Turunen, M., Heikkinen, T., Park, M.J., Makinen, N., Kivinummi, K., Lintula, S., Hotakainen, K., Nevanlinna, H., Hokland, P., Bohling, T., Butzow, R., Bohm, J., Mecklin, J.P., Jarvinen, H., Kontro, M., Visakorpi, T., Taipale, J., Varjosalo, M., Boyer, T.G., Vahteristo, P. Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms. Prostate. 2016; 76:22-31.

Kivela, R., Salmela, I., Nguyen, Y.H., Petrova, T.V., Koistinen, H.A., Wiener, Z., Alitalo, K. The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation. Nat Commun. 2016; 7:13124.

Korhonen, E.A., Lampinen, A., Giri, H., Anisimov, A., Kim, M., Allen, B., Fang, S., D'Amico, G., Sipila, T.J., Lohela, M., Strandin, T., Vaheri, A., Yla-Herttuala, S., Koh, G.Y., McDonald, D.M., Alitalo, K., Saharinen, P. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest. 2016; 126:3495-510.

Kuusela, S., Wang, H., Wasik, A.A., Suleiman, H., Lehtonen, S. Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. Cell Death Dis. 2016; 7:e2302.

Lampinen, A.M., Virman, J.P., Bono, P., Luukkaala, T.H., Sunela, K.L., Kujala, P.M., Saharinen, P., Kellokumpu-Lehtinen, P.I. Novel Angiogenesis Markers as Long-Term Prognostic Factors in Patients With Renal Cell Cancer. Clin Genitourin Cancer. 2016.

Lund, C., Pulli, K., Yellapragada, V., Giacobini, P., Lundin, K., Vuoristo, S., Tuuri, T., Noisa, P., Raivio, T. Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells. Stem Cell Reports. 2016; 7:149-57.

Mah, P.T., Novakovic, D., Saarinen, J., Van Landeghem, S., Peltonen, L., Laaksonen, T., Isomäki, A., Strachan, C.J. Elucidation of Compression-Induced Surface Crystallization in Amorphous Tablets Using Sum Frequency Generation (SFG) Microscopy. Pharmaceutical Research. 2016:1-14.

Makinen, N., Aavikko, M., Heikkinen, T., Taipale, M., Taipale, J., Koivisto-Korander, R., Butzow, R., Vahteristo, P. Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12. PLoS Genet. 2016; 12:e1005850.

Matilainen, O., Jha, S., Holmberg, C.I. 2016. Fluorescent Tools for In Vivo Studies on the Ubiquitin-Proteasome System. In Proteostasis: Methods and Protocols. R. Matthiesen, editor. Springer New York, New York, NY. 215-22.

Motazacker, M.M., Pirhonen, J., van Capelleveen, J.C., Weber-Boyvat, M., Kuivenhoven, J.A., Shah, S., Hovingh, G.K., Metso, J., Li, S., Ikonen, E., Jauhiainen, M., Dallinga-Thie, G.M., Olkkonen, V.M. A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity. Atherosclerosis. 2016; 249:140-7.

Muhonen, V., Salonius, E., Haaparanta, A.M., Jarvinen, E., Paatela, T., Meller, A., Hannula, M., Bjorkman, M., Pyhalto, T., Ella, V., Vasara, A., Toyras, J., Kellomaki, M., Kiviranta, I. Articular cartilage repair with recombinant human type II collagen/polylactide scaffold in a preliminary porcine study. J Orthop Res. 2016; 34:745-53.

Mäkela, J., Mudo, G., Pham, D.D., Di Liberto, V., Eriksson, O., Louhivuori, L., Bruelle, C., Soliymani, R., Baumann, M., Korhonen, L., Lalowski, M., Belluardo, N., Lindholm, D. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein. Eur J Neurosci. 2016; 43:626-39.

Okuneva, O., Li, Z., Korber, I., Tegelberg, S., Joensuu, T., Tian, L., Lehesjoki, A.E. Brain inflammation is accompanied by peripheral inflammation in Cstb -/- mice, a model for progressive myoclonus epilepsy. J Neuroinflammation. 2016; 13:298.

Pehkonen, H., von Nandelstadh, P., Karhemo, P.R., Lepikhova, T., Grenman, R., Lehti, K., Monni, O. Liprin-alpha1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery. Sci Rep. 2016; 6:24486.

Pirhonen, J., Arola, J., Sädevirta, S., Luukkonen, P., Karppinen, S.-M., Pihlajaniemi, T., Isomäki, A., Hukkanen, M., Yki-Järvinen, H., Ikonen, E. Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study. PLOS ONE. 2016; 11:e0147804.

Pfisterer, S.G., Peranen, J., Ikonen, E. LDL-cholesterol transport to the endoplasmic reticulum: current concepts. Curr Opin Lipidol. 2016; 27:282-7.

Rautiola, J., Lampinen, A., Mirtti, T., Ristimaki, A., Joensuu, H., Bono, P., Saharinen, P. Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma. PLoS One. 2016; 11:e0153745.

Rasanen, M., Degerman, J., Nissinen, T.A., Miinalainen, I., Kerkela, R., Siltanen, A., Backman, J.T., Mervaala, E., Hulmi, J.J., Kivela, R., Alitalo, K. VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A. 2016; 113:13144-9.

Robciuc, M.R., Kivela, R., Williams, I.M., de Boer, J.F., van Dijk, T.H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppanen, V.M., Kakela, R., Eklund, L., Wasserman, D.H., Groen, A.K., Alitalo, K. VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications. Cell Metab. 2016; 23:712-24.

Rämö, O., Kumar, D., Gucciardo, E., Joensuu, M., Saarekas, M., Vihinen, H., Belevich, I., Smolander, O.-P., Qian, K., Auvinen, P., Jokitalo, E. NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology. Scientific Reports. 2016; 6:35969.

Salo, V.T., Belevich, I., Li, S., Karhinen, L., Vihinen, H., Vigouroux, C., Magre, J., Thiele, C., Holtta-Vuori, M., Jokitalo, E., Ikonen, E. Seipin regulates ER-lipid droplet contacts and cargo delivery. EMBO J. 2016; 35:2699-716.

Saurus, P., Kuusela, S., Dumont, V., Lehtonen, E., Fogarty, C.L., Lassenius, M.I., Forsblom, C., Lehto, M., Saleem, M.A., Groop, P.H., Lehtonen, S. Cyclin-dependent kinase 2 protects podocytes from apoptosis. Sci Rep. 2016; 6:21664.

Tervaniemi, M.H., Katayama, S., Skoog, T., Siitonen, H.A., Vuola, J., Nuutila, K., Sormunen, R., Johnsson, A., Linnarsson, S., Suomela, S., Kankuri, E., Kere, J., Elomaa, O. NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis. Sci Rep. 2016; 6:22745.

Vishwanatha, K.S., Back, N., Lam, T.T., Mains, R.E., Eipper, B.A. O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking. J Biol Chem. 2016; 291:9835-50.

Ylosmaki, L., Fagerlund, R., Kuisma, I., Julkunen, I., Saksela, K. Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein. Viruses. 2016; 8:101.

Zou, J., Isomäki, A., Hirvonen, T., Aarnisalo, A., Jero, J., Pyykkö, I. Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy. Journal of Otology. 2016; 11:127-33.

Aspelund, A., Antila, S., Proulx, S.T., Karlsen, T.V., Karaman, S., Detmar, M., Wiig, H., Alitalo, K. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015; 212:991-9.

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y.A., Loizides-Mangold, U., Riezman, H., Bittman, R., Ikonen, E. LAPTM4B facilitates late endosomal ceramide export to control cell death pathways. Nat Chem Biol. 2015; 11:799-806.

Bonnemaison, M.L., Back, N., Duffy, M.E., Ralle, M., Mains, R.E., Eipper, B.A. Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine alpha-Amidating Monooxygenase, a Luminal Cuproenzyme. J Biol Chem. 2015; 290:21264-79.

Castren, E., Sillat, T., Oja, S., Noro, A., Laitinen, A., Konttinen, Y.T., Lehenkari, P., Hukkanen, M., Korhonen, M. Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum. Stem Cell Res Ther. 2015; 6:167.

Christophersen, P.C., Birch, D., Saarinen, J., Isomaki, A., Nielsen, H.M., Yang, M., Strachan, C.J., Mu, H. Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy. J Control Release. 2015; 197:111-20.

Darville, N., Saarinen, J., Isomaki, A., Khriachtchev, L., Cleeren, D., Sterkens, P., van Heerden, M., Annaert, P., Peltonen, L., Santos, H.A., Strachan, C.J., Van den Mooter, G. Multimodal non-linear optical imaging for the investigation of drug nano-/microcrystal-cell interactions. Eur J Pharm Biopharm. 2015; 96:338-48.

den Hollander, B., Dudek, M., Ojanpera, I., Kankuri, E., Hyytia, P., Korpi, E.R. Manganese-enhanced magnetic resonance imaging reveals differential long-term neuroadaptation after methamphetamine and the substituted cathinone 4-methylmethcathinone (mephedrone). Int J Neuropsychopharmacol. 2015; 18.

Faisal, I., Kauppi, L. Sex chromosome recombination failure, apoptosis, and fertility in male mice. Chromosoma. 2015.

Hakanpaa, L., Sipila, T., Leppanen, V.M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K., Saharinen, P. Endothelial destabilization by angiopoietin-2 via integrin beta1 activation. Nat Commun. 2015; 6:5962.

Holopainen, T., Rasanen, M., Anisimov, A., Tuomainen, T., Zheng, W., Tvorogov, D., Hulmi, J.J., Andersson, L.C., Cenni, B., Tavi, P., Mervaala, E., Kivela, R., Alitalo, K. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proc Natl Acad Sci U S A. 2015; 112:13063-8.

Hyvonen, M.E., Dumont, V., Tienari, J., Lehtonen, E., Ustinov, J., Havana, M., Jalanko, H., Otonkoski, T., Miettinen, P.J., Lehtonen, S. Early-onset diabetic E1-DN mice develop albuminuria and glomerular injury typical of diabetic nephropathy. Biomed Res Int. 2015; 2015:102969.

Jarvinen, E., Ismail, K., Muniandy, M., Bogl, L.H., Heinonen, S., Tummers, M., Miettinen, S., Kaprio, J., Rissanen, A., Ollikainen, M., Pietilainen, K.H. Biotin-dependent functions in adiposity: a study of monozygotic twin pairs. Int J Obes (Lond). 2015.

Jokinen, R., Lahtinen, T., Marttinen, P., Myohanen, M., Ruotsalainen, P., Yeung, N., Shvetsova, A., Kastaniotis, A.J., Hiltunen, J.K., Ohman, T., Nyman, T.A., Weiler, H., Battersby, B.J. Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice. Genetics. 2015; 200:221-35.

Lahtela, J., Pradhan, B., Narhi, K., Hemmes, A., Sarkioja, M., Kovanen, P.E., Brown, A., Verschuren, E.W. The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis. Dis Model Mech. 2015; 8:393-401.

Loukovaara, S., Gucciardo, E., Repo, P., Lohi, J., Salven, P., Lehti, K. A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion. Case Rep Ophthalmol. 2015; 6:228-38.

Marques, E., Englund, J.I., Tervonen, T.A., Virkunen, E., Laakso, M., Myllynen, M., Makela, A., Ahvenainen, M., Lepikhova, T., Monni, O., Hautaniemi, S., Klefstrom, J. Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers. Oncogene. 2015.

Mattila, O.S., Rantanen, V., Saksi, J., Strbian, D., Pikkarainen, T., Hautaniemi, S., Lindsberg, P.J. Workflow for automated quantification of cerebromicrovascular gelatinase activity. Microvasc Res. 2015; 97:19-24.

Nurmi, H., Saharinen, P., Zarkada, G., Zheng, W., Robciuc, M.R., Alitalo, K. VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption. EMBO Mol Med. 2015; 7:1418-25.

Nuutila, K., Peura, M., Suomela, S., Hukkanen, M., Siltanen, A., Harjula, A., Vuola, J., Kankuri, E. Recombinant human collagen III gel for transplantation of autologous skin cells in porcine full-thickness wounds. J Tissue Eng Regen Med. 2015; 9:1386-93.

Polinati, P.P., Ilmarinen, T., Trokovic, R., Hyotylainen, T., Otonkoski, T., Suomalainen, A., Skottman, H., Tyni, T. Patient-Specific Induced Pluripotent Stem Cell-Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency. Invest Ophthalmol Vis Sci. 2015; 56:3371-82.

Polinati, P.P., Valanne, L., Tyni, T. Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations. Brain Dev. 2015; 37:107-13.

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Riihijarvi, S., Fiskvik, I., Taskinen, M., Vajavaara, H., Tikkala, M., Yri, O., Karjalainen-Lindsberg, M.L., Delabie, J., Smeland, E., Holte, H., Leppa, S. Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trial. Haematologica. 2015; 100:238-45.

Scifo, E., Szwajda, A., Soliymani, R., Pezzini, F., Bianchi, M., Dapkunas, A., Debski, J., Uusi-Rauva, K., Dadlez, M., Gingras, A.C., Tyynela, J., Simonati, A., Jalanko, A., Baumann, M.H., Lalowski, M. Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. J Proteomics. 2015; 123:42-53.

Scifo, E., Szwajda, A., Soliymani, R., Pezzini, F., Bianchi, M., Dapkunas, A., Debski, J., Uusi-Rauva, K., Dadlez, M., Gingras, A.C., Tyynela, J., Simonati, A., Jalanko, A., Baumann, M.H., Lalowski, M. Quantitative analysis of PPT1 interactome in human neuroblastoma cells. Data Brief. 2015; 4:207-16.

Tamminen, J.A., Yin, M., Ronty, M., Sutinen, E., Pasternack, A., Ritvos, O., Myllarniemi, M., Koli, K. Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 2015; 332:102-15.

Tamminen, K., Balboa, D., Toivonen, S., Pakarinen, M.P., Wiener, Z., Alitalo, K., Otonkoski, T. Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1. PLoS One. 2015; 10:e0134551.

Tatti, O., Gucciardo, E., Pekkonen, P., Holopainen, T., Louhimo, R., Repo, P., Maliniemi, P., Lohi, J., Rantanen, V., Hautaniemi, S., Alitalo, K., Ranki, A., Ojala, P.M., Keski-Oja, J., Lehti, K. MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma. Cancer Res. 2015; 75:2083-94.

Tervonen, T.A., Belitskin, D., Pant, S.M., Englund, J.I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P.E., Poso, A., Klefstrom, J. Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene. 2015.

Tolvanen, T.A., Dash, S.N., Polianskyte-Prause, Z., Dumont, V., Lehtonen, S. Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes. J Cell Sci. 2015; 128:4588-600.

Valimaki, N., Demir, H., Pitkanen, E., Kaasinen, E., Karppinen, A., Kivipelto, L., Schalin-Jantti, C., Aaltonen, L.A., Karhu, A. Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas. J Clin Endocrinol Metab. 2015; 100:3918-27.

Vassilev, B., Sihto, H., Li, S., Holtta-Vuori, M., Ilola, J., Lundin, J., Isola, J., Kellokumpu-Lehtinen, P.L., Joensuu, H., Ikonen, E. Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers. Am J Pathol. 2015; 185:987-1000.

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Wiese, K.E., Haikala, H.M., von Eyss, B., Wolf, E., Esnault, C., Rosenwald, A., Treisman, R., Klefstrom, J., Eilers, M. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. EMBO J. 2015; 34:1554-71.

Zarkada, G., Heinolainen, K., Makinen, T., Kubota, Y., Alitalo, K. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci U S A. 2015; 112:761-6.

Af Hallstrom, T.M., Zhao, H., Tian, J., Rantanen, V., Reese, S.W., Nolley, R., Laiho, M., Peehl, D.M. A tissue graft model of DNA damage response in the normal and malignant human prostate. J Urol. 2014; 191:842-9.

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Bautista, G., Pfisterer, S.G., Huttunen, M.J., Ranjan, S., Kanerva, K., Ikonen, E., Kauranen, M. Polarized THG microscopy identifies compositionally different lipid droplets in mammalian cells. Biophys J. 2014; 107:2230-6.

Colis, L., Peltonen, K., Sirajuddin, P., Liu, H., Sanders, S., Ernst, G., Barrow, J.C., Laiho, M. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014; 5:4361-9.

D'Amico, G., Korhonen, E.A., Anisimov, A., Zarkada, G., Holopainen, T., Hagerling, R., Kiefer, F., Eklund, L., Sormunen, R., Elamaa, H., Brekken, R.A., Adams, R.H., Koh, G.Y., Saharinen, P., Alitalo, K. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest. 2014; 124:824-34.

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Dudek, M., Abo-Ramadan, U., Hermann, D., Brown, M., Canals, S., Sommer, W.H., Hyytia, P. Brain activation induced by voluntary alcohol and saccharin drinking in rats assessed with manganese-enhanced magnetic resonance imaging. Addict Biol. 2014.

Hakonen, E., Ustinov, J., Eizirik, D.L., Sariola, H., Miettinen, P.J., Otonkoski, T. In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes. Diabetologia. 2014; 57:970-9.

Hakonen, E., Ustinov, J., Palgi, J., Miettinen, P.J., Otonkoski, T. EGFR signaling promotes beta-cell proliferation and survivin expression during pregnancy. PLoS One. 2014; 9:e93651.

Hyrskyluoto, A., Bruelle, C., Lundh, S.H., Do, H.T., Kivinen, J., Rappou, E., Reijonen, S., Waltimo, T., Petersen, A., Lindholm, D., Korhonen, L. Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1alpha. Hum Mol Genet. 2014; 23:5928-39.

Hyvonen, M., Enback, J., Huhtala, T., Lammi, J., Sihto, H., Weisell, J., Joensuu, H., Rosenthal-Aizman, K., El-Andaloussi, S., Langel, U., Narvanen, A., Bergers, G., Laakkonen, P. Novel target for peptide-based imaging and treatment of brain tumors. Mol Cancer Ther. 2014; 13:996-1007.

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Jarvinen, E., Muhonen, V., Haaparanta, A.M., Kellomaki, M., Kiviranta, I. Optical projection tomography can be used to investigate spatial distribution of chondrocytes in three-dimensional biomaterial scaffolds for cartilage tissue engineering. Biomed Mater Eng. 2014; 24:1549-53.

Jeltsch, M., Jha, S.K., Tvorogov, D., Anisimov, A., Leppanen, V.M., Holopainen, T., Kivela, R., Ortega, S., Karpanen, T., Alitalo, K. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Circulation. 2014; 129:1962-71.

Joensuu, T., Tegelberg, S., Reinmaa, E., Segerstrale, M., Hakala, P., Pehkonen, H., Korpi, E.R., Tyynela, J., Taira, T., Hovatta, I., Kopra, O., Lehesjoki, A.E. Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation. PLoS One.2014; 9:e89321.

Kivela, R., Bry, M., Robciuc, M.R., Rasanen, M., Taavitsainen, M., Silvola, J.M., Saraste, A., Hulmi, J.J., Anisimov, A., Mayranpaa, M.I., Lindeman, J.H., Eklund, L., Hellberg, S., Hlushchuk, R., Zhuang, Z.W., Simons, M., Djonov, V., Knuuti, J., Mervaala, E., Alitalo, K. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol Med. 2014; 6:307-21.

Kupari, J., Airaksinen, M.S. Different requirements for GFRalpha2-signaling in three populations of cutaneous sensory neurons. PLoS One. 2014; 9:e104764.

Marbacher, S., Marjamaa, J., Bradacova, K., von Gunten, M., Honkanen, P., Abo-Ramadan, U., Hernesniemi, J., Niemela, M., Frosen, J. Loss of mural cells leads to wall degeneration, aneurysm growth, and eventual rupture in a rat aneurysm model. Stroke. 2014; 45:248-54.

Marinkovic, I., Mattila, O.S., Strbian, D., Meretoja, A., Shekhar, S., Saksi, J., Abo-Ramadan, U., Rantanen, V., Lindsberg, P.J., Tatlisumak, T. Evolution of intracerebral hemorrhage after intravenous tPA: reversal of harmful effects with mast cell stabilization. J Cereb Blood Flow Metab. 2014; 34:176-81.

Neuvonen, M., Manna, M., Mokkila, S., Javanainen, M., Rog, T., Liu, Z., Bittman, R., Vattulainen, I., Ikonen, E. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS One. 2014; 9:e103743.

Nousiainen, H.O., Quintero, I.B., Myohanen, T.T., Voikar, V., Mijatovic, J., Segerstrale, M., Herrala, A.M., Kulesskaya, N., Pulkka, A.E., Kivinummi, T., Abo-Ramadan, U., Taira, T., Piepponen, T.P., Rauvala, H., Vihko, P. Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations. PLoS One. 2014; 9:e97851.

Parviainen, S., Ahonen, M., Diaconu, I., Hirvinen, M., Karttunen, A., Vaha-Koskela, M., Hemminki, A., Cerullo, V. CD40 ligand and tdTomato-armed vaccinia virus for induction of antitumor immune response and tumor imaging. Gene Ther. 2014; 21:195-204.

Peltonen, K., Colis, L., Liu, H., Jaamaa, S., Zhang, Z., Af Hallstrom, T., Moore, H.M., Sirajuddin, P., Laiho, M. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014; 13:2537-46.

Peltonen, K., Colis, L., Liu, H., Trivedi, R., Moubarek, M.S., Moore, H.M., Bai, B., Rudek, M.A., Bieberich, C.J., Laiho, M. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell. 2014; 25:77-90.

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R., Olkkonen, V.M. PNPLA3 mediates hepatocyte triacylglycerol remodeling. J Lipid Res. 2014; 55:739-46.

Tamminen, J.A., Yin, M., Ronty, M., Sutinen, E., Pasternack, A., Ritvos, O., Myllarniemi, M., Koli, K. Overexpression of activin-A and -B in malignant mesothelioma - Attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 2014.

Taskinen, M., Louhimo, R., Koivula, S., Chen, P., Rantanen, V., Holte, H., Delabie, J., Karjalainen-Lindsberg, M.L., Bjorkholm, M., Fluge, O., Pedersen, L.M., Fjorden, K., Jerkeman, M., Eriksson, M., Hautaniemi, S., Leppa, S. Deregulation of COMMD1 is associated with poor prognosis in diffuse large B-cell lymphoma. PLoS One. 2014; 9:e91031.

Wasik, A.A., Koskelainen, S., Hyvonen, M.E., Musante, L., Lehtonen, E., Koskenniemi, K., Tienari, J., Vaheri, A., Kerjaschki, D., Szalay, C., Revesz, C., Varmanen, P., Nyman, T.A., Hamar, P., Holthofer, H., Lehtonen, S. Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 in cultured podocytes. Am J Pathol. 2014; 184:1727-39.

Wiener, Z., Band, A.M., Kallio, P., Hogstrom, J., Hyvonen, V., Kaijalainen, S., Ritvos, O., Haglund, C., Kruuna, O., Robine, S., Louvard, D., Ben-Neriah, Y., Alitalo, K. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. Proc Natl Acad Sci U S A. 2014; 111:E2229-36.

Wiener, Z., Hogstrom, J., Hyvonen, V., Band, A.M., Kallio, P., Holopainen, T., Dufva, O., Haglund, C., Kruuna, O., Oliver, G., Ben-Neriah, Y., Alitalo, K. Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance. Cell Rep. 2014; 8:1943-56.

von Nandelstadh, P., Gucciardo, E., Lohi, J., Li, R., Sugiyama, N., Carpen, O., Lehti, K. Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton. Mol Biol Cell. 2014; 25:2556-70.

Zheng, W., Nurmi, H., Appak, S., Sabine, A., Bovay, E., Korhonen, E.A., Orsenigo, F., Lohela, M., D'Amico, G., Holopainen, T., Leow, C.C., Dejana, E., Petrova, T.V., Augustin, H.G., Alitalo, K. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes Dev. 2014; 28:1592-603.

Zhong, W., Zhou, Y., Li, J., Mysore, R., Luo, W., Li, S., Chang, M.S., Olkkonen, V.M., Yan, D. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. Exp Cell Res. 2014; 322:227-35.

Anisimov, A., Leppanen, V.M., Tvorogov, D., Zarkada, G., Jeltsch, M., Holopainen, T., Kaijalainen, S., Alitalo, K. The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Sci Signal. 2013; 6:ra52.

Anisimov, A., Tvorogov, D., Alitalo, A., Leppanen, V.M., An, Y., Han, E.C., Orsenigo, F., Gaal, E.I., Holopainen, T., Koh, Y.J., Tammela, T., Korpisalo, P., Keskitalo, S., Jeltsch, M., Yla-Herttuala, S., Dejana, E., Koh, G.Y., Choi, C., Saharinen, P., Alitalo, K. Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation. 2013; 127:424-34.

Gaal, E.I., Tammela, T., Anisimov, A., Marbacher, S., Honkanen, P., Zarkada, G., Leppanen, V.M., Tatlisumak, T., Hernesniemi, J., Niemela, M., Alitalo, K. Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization. Blood. 2013; 122:658-65.

Hackman, P., Sarparanta, J., Lehtinen, S., Vihola, A., Evila, A., Jonson, P.H., Luque, H., Kere, J., Screen, M., Chinnery, P.F., Ahlberg, G., Edstrom, L., Udd, B. Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1. Ann Neurol. 2013.

Holtta-Vuori, M., Salo, V.T., Ohsaki, Y., Suster, M.L., Ikonen, E. Alleviation of seipinopathy-related ER stress by triglyceride storage. Hum Mol Genet. 2013; 22:1157-66.

Hyrskyluoto, A., Pulli, I., Tornqvist, K., Ho, T.H., Korhonen, L., Lindholm, D. Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kappaB pathway. Cell Death Dis. 2013; 4:e646.

Kaivosoja, E., Suvanto, P., Barreto, G., Aura, S., Soininen, A., Franssila, S., Konttinen, Y.T. Cell adhesion and osteogenic differentiation on three-dimensional pillar surfaces. J Biomed Mater Res A. 2013; 101:842-52.

Kanerva, K., Uronen, R.L., Blom, T., Li, S., Bittman, R., Lappalainen, P., Peranen, J., Raposo, G., Ikonen, E. LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route. Dev Cell. 2013; 27:249-62.

Keranen, M.A., Tuuminen, R., Syrjala, S., Krebs, R., Walkinshaw, G., Flippin, L.A., Arend, M., Koskinen, P.K., Nykanen, A.I., Lemstrom, K.B. Differential effects of pharmacological HIF preconditioning of donors versus recipients in rat cardiac allografts. Am J Transplant. 2013; 13:600-10.

Koch, S., Scifo, E., Rokka, A., Trippner, P., Lindfors, M., Korhonen, R., Corthals, G.L., Virtanen, I., Lalowski, M., Tyynela, J. Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain. Neurobiol Dis. 2013; 50:107-19.

Koivuniemi, R., Makela, J., Hokkanen, M.E., Bruelle, C., Ho, T.H., Ola, R., Korhonen, L., Schroder, J., Kataoka, H., Lindholm, D. Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells. PLoS One. 2013; 8:e56117.

Li, L., Hu, Y., Ylivinkka, I., Li, H., Chen, P., Keski-Oja, J., Hyytiainen, M. NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence. PLoS One. 2013; 8:e80363.

Makarov, A., Ylivinkka, I., Nyman, T.A., Hyytiainen, M., Keski-Oja, J. Ephrin-As, Eph receptors and integrin alpha3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells. Cell Biol Int. 2013; 37:1080-8.

Markkanen, M., Karhunen, T., Llano, O., Ludwig, A., Rivera, C., Uvarov, P., Airaksinen, M.S. Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS. J Comp Neurol. 2013.

Matilainen, O., Arpalahti, L., Rantanen, V., Hautaniemi, S., Holmberg, C.I. Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Cell Rep. 2013; 3:1980-95.

Mikkonen, L., Hirvonen, J., Janne, O.A. SUMO-1 regulates body weight and adipogenesis via PPARgamma in male and female mice. Endocrinology. 2013; 154:698-708.

Moore, H.M., Bai, B., Matilainen, O., Colis, L., Peltonen, K., Laiho, M. Proteasome activity influences UV-mediated subnuclear localization changes of NPM. PLoS One. 2013; 8:e59096.

Nieminen, A.I., Eskelinen, V.M., Haikala, H.M., Tervonen, T.A., Yan, Y., Partanen, J.I., Klefstrom, J. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc Natl Acad Sci U S A. 2013; 110:E1839-48.

Pajarinen, J., Kouri, V.P., Jamsen, E., Li, T.F., Mandelin, J., Konttinen, Y.T. The response of macrophages to titanium particles is determined by macrophage polarization. Acta Biomater. 2013; 9:9229-40.

Pietiainen, V., Vassilev, B., Blom, T., Wang, W., Nelson, J., Bittman, R., Back, N., Zelcer, N., Ikonen, E. NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation. J Cell Sci. 2013; 126:3961-71.

Quintero, I.B., Herrala, A.M., Araujo, C.L., Pulkka, A.E., Hautaniemi, S., Ovaska, K., Pryazhnikov, E., Kulesskiy, E., Ruuth, M.K., Soini, Y., Sormunen, R.T., Khirug, L., Vihko, P.T. Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma. PLoS One. 2013; 8:e73072.

Raissadati, A., Jokinen, J.J., Syrjala, S.O., Keranen, M.A., Krebs, R., Tuuminen, R., Arnaudova, R., Rouvinen, E., Anisimov, A., Soronen, J., Pajusola, K., Alitalo, K., Nykanen, A.I., Lemstrom, K. Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants. Transpl Int. 2013; 26:1126-37.

Sarek, G., Ma, L., Enback, J., Jarviluoma, A., Moreau, P., Haas, J., Gessain, A., Koskinen, P.J., Laakkonen, P., Ojala, P.M. Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. Oncogene. 2013; 32:1091-8.

Scifo, E., Szwajda, A., Debski, J., Uusi-Rauva, K., Kesti, T., Dadlez, M., Gingras, A.C., Tyynela, J., Baumann, M.H., Jalanko, A., Lalowski, M. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. J Proteome Res. 2013; 12:2101-15.

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Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res. 2012; 72:3512-3521.

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Nokisalmi P, Rajecki M, Pesonen S, Escutenaire S, Soliymani R, Tenhunen M, Ahtiainen L, Hemminki A. Radiation-Induced Upregulation of Gene Expression from Adenoviral Vectors Mediated by DNA Damage Repair and Regulation. Int J Radiat Oncol Biol Phys. 2012; 83:376-384.

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Peura M, Kaartinen I, Suomela S, Hukkanen M, Bizik J, Harjula A, Kankuri E, Vuola J. Improved skin wound epithelialization by topical delivery of soluble factors from fibroblast aggregates. Burns 2012; 38:541-550.

Pitkonen M, Abo-Ramadan U, Marinkovic I, Pedrono E, Hasan KM, Strbian D, Durukan A, Tatlisumak T. Long-term evolution of diffusion tensor indices after temporary experimental ischemic stroke in rats. Brain Res. 2012; 1445:103-110.

Robciuc MR, Skrobuk P, Anisimov A, Olkkonen VM, Alitalo K, Eckel RH, Koistinen HA, Jauhiainen M, Ehnholm C. Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. PLoS One. 2012; 7:e46212.

Sarek G, Ma L, Enbäck J, Järviluoma A, Moreau P, Haas J, Gessain A, Koskinen PJ, Laakkonen P, Ojala PM. Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. Oncogene. 2012; Epub ahead of print.

Sarparanta J, Jonson PH, Golzio C, Sandell S, Luque H, Screen M, McDonald K, Stajich JM, Mahjneh I, Vihola A, Raheem O, Penttilä S, Lehtinen S, Huovinen S, Palmio J, Tasca G, Ricci E, Hackman P, Hauser M, Katsanis N, Udd B. Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. Nat Genet. 2012; 44:450–455.

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Tamminen JA, Myllärniemi M, Hyytiäinen M, Keski-Oja J, Koli K. Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling. J Cell Biochem. 2012; 113:2234-2247

Tervaniemi MH, Siitonen HA, Söderhäll C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J, Elomaa O. Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization. PLoS One. 2012; 7:e49920.

Thiel A, Narko K, Heinonen M, Hemmes A, Tomasetto C, Rio MC, Haglund C, Mäkelä TP, Ristimäki A. Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. Int J Cancer. 2012; 131:1032-41.

Uusi-Rauva K, Kyttälä A, van der Kant R, Vesa J, Tanhuanpää K, Neefjes J, Olkkonen VM, Jalanko A. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci. 2012; 69:2075-2089.

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Zou J, Sood R, Ranjan S, Poe D, Ramadan UA, Pyykkö I, Kinnunen PK. Size-dependent passage of liposome nanocarriers with preserved posttransport integrity across the middle-inner ear barriers in rats. Otol Neurotol. 2012; 33:666-673.

Tammela T, Saaristo A, Holopainen T, Ylä-Herttuala S, Andersson LC, Virolainen S, Immonen I,Alitalo K. Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis. Sci Transl Med. 2011 Feb 9;3(69)

Leppänen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Ylä-Herttuala S, Ballmer-Hofer K, Alitalo K. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood. 2011 Feb 3;117(5):1507-15. Epub 2010 Dec 8.

Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK. Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLOS Genet. 2011 Jun;7(6):e1002119. Epub 2011 Jun 9.

Karhemo, P-R., Rivinoja, A., Lundin, J., Hyvönen, M., Chernenko, A., Lammi, J., Sihto, H., Lundin, M., Heikkilä, P., Joensuu, H., Bono, P. and Laakkonen, P. An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer. Am. J. Pathol. 2011;179(2):1004-14.

Mattila OS, Strbian D, Saksi J, Pikkarainen TO, Rantanen V, Tatlisumak T, Lindsberg PJ. Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation. Stroke. 2011 Dec;42(12):3600-5. Epub 2011 Oct 6.

Moore HM, Bai B, Boisvert FM, Latonen L, Rantanen V, Simpson JC, Pepperkok R, Lamond AI, Laiho M. Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. Mol Cell Proteomics. 2011 Oct;10(10):M111.009241. Epub. 2011 Jul 21.

Latonen L, Moore HM, Bai B, Jäämaa S, Laiho M. Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability. Oncogene. 2011 Feb 17;30(7):790-805. Epub 2010 Oct 18.

Tuuminen, R., Syrjälä, S., Krebs, R., Keränen, M.A.I., Koli, K., Abo-Ramadan, U., Nykänen, A.I. and Lemström K.B.: Donor simvastatin treatment abolishes rat cardiac allograft ischemia-reperfusion injury and chronic rejection through microvascular protection. Circulation. 2011;124:1138-1150

Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol. 2011 Sep 11;13(10):1202-13.

Hernández M, Gamonal J, Salo T, Tervahartiala T, Hukkanen M, Tjäderhane L, Sorsa T. Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice. J Periodontal Res. 2011;46:58-66.

Tatti O, Arjama M, Ranki A, Weiss SJ, Keski-Oja J, Kaisa Lehti. (2011) Membrane-Type-3 Matrix Metalloproteinase (MT3-MMP) Functions as a Matrix Composition-Dependent Effector of Melanoma Cell Invasion. PLOS ONE. 6(12): e28325. doi:10.1371/journal.pone.0028325

Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T, Lehti K, Ylä-Herttuala S, Alitalo K. Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. Blood. 2011 Jul 28;118(4):1154-62. Epub 2011 May 12.

Thiel A, Narko K, Heinonen M, Hemmes A, Tomasetto C, Rio MC, Haglund C, Mäkelä TP, Ristimäki A. Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. Int J Cancer. 2011 Oct 27. doi: 10.1002/ijc.27331. [Epub ahead of print]

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Marjamaa J, Antell H, Abo-Ramadan U, Hernesniemi JA, Niemelä MR, Kangasniemi M. High-resolution TOF MR angiography at 4.7 Tesla for volumetric and morphologic evaluation of coiled aneurysm neck remnants in a rat model. Acta Radiol. 2011;52:340-8.

Planagumà P, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M. Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma. Hum Pathol. 2011;42:57-67.

Vihervaara T, Uronen RL, Wohlfahrt G, Björkhem I, Ikonen E, Olkkonen VM. Sterol binding by OSBP-related protein 1L regulates late endosome motility and function. Cell Mol Life Sci. 2011;68:537-51.

Zou J, Yoshida T, Ramadan UA, Pyykkö I. Dynamic enhancement of the rat inner ear after ultra-small-volume administration of Gd-DOTA to the medial wall of the middle ear cavity. ORL J Otorhinolaryngol Relat Spec. 2011;73:275-81.

Alan E. Renton, Elisa Majounie, Adrian Waite, Javier Simón-Sánchez, Sara Rollinson, J. Raphael Gibbs, Jennifer C. Schymick, Hannu Laaksovirta, John C. van Swieten, Liisa Myllykangas, Hannu Kalimo, Anders Paetau, Yevgeniya Abramzon, Anne M. Remes, Alice Kaganovich, Sonja W. Scholz, Jamie Duckworth, Jinhui Ding, Daniel W. Harmer, Dena G. Hernandez, Janel O. Johnson, Kin Mok, Mina Ryten, Danyah Trabzuni, Rita J. Guerreiro, Richard W. Orrell, James Neal, Alex Murray, Justin Pearson, Iris E. Jansen, David Sondervan, Harro Seelaar, Derek Blake, Kate Young, Nicola Halliwell, Janis Bennion Callister, Greg Toulson, Anna Richardson, Alex Gerhard, Julie Snowden, David Mann, David Neary, Michael A. Nalls, Terhi Peuralinna, Lilja Jansson, Veli-Matti Isoviita, Anna-Lotta Kaivorinne, Maarit Hölttä-Vuori, Elina Ikonen, Raimo Sulkava, Michael Benatar, Joanne Wuu, Adriano Chió, Gabriella Restagno, Giuseppe Borghero, Mario Sabatelli, The ITALSGEN Consortium, David Heckerman, Ekaterina Rogaeva, Lorne Zinman, Jeffrey D. Rothstein, Michael Sendtner, Carsten Drepper, Evan E. Eichler, Can Alkan, Ziedulla Abdullaev, Svetlana D. Pack, Amalia Dutra, Evgenia Pak, John Hardy, Andrew Singleton, Nigel M. Williams, Peter Heutink, Stuart Pickering-Brown, Huw R. Morris, Pentti J. Tienari, and Bryan J. Traynor. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD. Neuron. 2011;72:257-268

Anna Meuronen. The role of inflammation and matrix proteins in airway remodelling. Helsinki University Biomedical Dissertations. 2011

Camilla Norrmén, Tuomas Tammela, Tatiana V. Petrova and Kari Alitalo. Biological Basis of Therapeutic Lymphangiogenesis. Circulation. 2011;123:1335-1351

Chiara Procaccini, Teemu Aitta-aho, Külli Jaako-Movits, Alexander Zharkovsky, Anne Panhelainen, Rolf Sprengel, Anni-Maija Linden and Esa R. Korpi. Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice. European Journal of Neuroscience. 2011;33:161-174

Fang Cheng, Pirita Pekkonen, Simonas Laurinavicius, Nami Sugiyama, Stephen Henderson, Thomas Günther, Ville Rantanen, Elisa Kaivanto, Mervi Aavikko, Grzegorz Sarek, Sampsa Hautaniemi, Peter Biberfeld, Lauri Aaltonen, Adam Grundhoff, Chris Boshoff, Kari Alitalo, Kaisa Lehti, and Päivi M. Ojala. KSHV-Initiated Notch Activation Leads to Membrane-Type-1MatrixMetalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition . Cell Host & Microbe. 2011;10:577-590

Ilkka Liikanen, Vladia Monsurrò, Laura Ahtiainen, Mari Raki, Tanja Hakkarainen, Iulia Diaconu, Sophie Escutenaire, Otto Hemminki, João D Dias, Vincenzo Cerullo, Anna Kanerva, Sari Pesonen, Daniela Marzioni, Marco Colombatti and Akseli Hemminki. Induction of Interferon Pathways Mediates In Vivo Resistance to Oncolytic Adenovirus. Molecular Therapy. 2011;19:10:1858-1866

Karoliina Vuoriluoto, Gunilla Högnäs, Pipsa Meller, Kaisa Lehti, Johanna Ivaska. Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP. Matrix Biology. 2011;30:207-217

Maria Sundvik, Hisaaki Kudo, Pauliina Toivonen, Stanislav Rozov, Yu-Chia Chen, and Pertti Panula. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. FASEB Journal. 2011;25:4338-4347

Maurice Jansen . Using fluorescent and non-fluorescent sterols to study rafts and intracellular cholesterol transport in mammalian cells. Helsinki University Biomedical Dissertations. 2011

Maurice Jansen, Yuki Ohsaki, Laura Rita Rega, Robert Bittman, Vesa M. Olkkonen and Elina Ikonen. Role of ORPs in Sterol Transport from Plasma Membrane to ER and Lipid Droplets in Mammalian Cells. Traffic. 2011;12:218-231

Noora Putkonen, Jyrki P. Kukkonen, Guiseppa Mudo, Jaana Putula, Natale Belluardo, Dan Lindholm and Laura Korhonen. Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus. European Journal of Neuroscience. 2011;34:1212-1221

Pauliina Porola. Sex steroids in Sjögren's syndrome. Helsinki University Biomedical Dissertations. 2011

Pernilla von Nandelstadh, Rabah Soliymani, Marc Baumann and Olli Carpen. Analysis of myotilin turnover provides mechanistic insight into the role of myotilinopathy-causing mutations. Biochemical Journal. 2011;436:113-121

Roxana Ola, Madis Jakobson, Jouni Kvist, Nina Perälä, Satu Kuure, Karl-Heinz Braunewell, Darren Bridgewater, Norman D. Rosenblum, Dmitri Chilov, Tiina Immonen, Kirsi Sainio, and Hannu Sariola. The GDNF Target Vsnl1 Marks the Ureteric Tip. Journal of the American society of nephrology. 2011;22:274-284

Sari Jäämaa. DNA damage recognition in the normal epithelium of human prostate and seminal vesicles. Helsinki University Biomedical Dissertations. 2011

Satu Massinen, Marie-Estelle Hokkanen, Hans Matsson, Kristiina Tammimies, Isabel Tapia-Páez, Vanina Dahlström-Heuser, Juha Kuja-Panula, Jan Burghoorn, Kristian E. Jeppsson, Peter Swoboda, Myriam Peyrard-Janvid, Rune Toftgård, Eero Castrén, Juha Kere. Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons. PLoS One. 2011;6:6:e20580

Wenbin Zhong, You Zhou, Shiqian Li, Tianhong Zhou, Hongling Ma, Kunde Wei, Hongye Li, Vesa M. Olkkonen, Daoguang Yana. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Experimental Cell Research. 2011;317:2353-2363

Ahonen MT, Diaconu I, Pesonen S, Kanerva A, Baumann M, Parviainen ST, Spiller B, Cerullo V, Hemminki A. Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5. PLoS One. 2010;5(9).

Antell H, Numminen J, Abo-Ramadan U, Niemelä MR, Hernesniemi JA, Kangasniemi M. Optimization of high-resolution USPIO magnetic resonance imaging at 4.7 T using novel phantom with minimal structural interference. J Magn Reson Imaging. 2010;32:1184-96.

Blom T, Bäck N, Mutka AL, Bittman R, Li Z, de Lera A, Kovanen PT, Diczfalusy U, Ikonen E. FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Circ Res. 2010;106:720-9.

Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, Mervaala E, Andersson LC, Knuuti J, Alitalo K. VEGF-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak or inflammation. Circulation. 2010;122:1725-33.

Bäck N, Rajagopal C, Mains RE, Eipper BA. Secretory granule membrane protein recycles through multivesicular bodies. Traffic. 2010;11:972-86.

Enzerink A, Rantanen V, Vaheri A. Fibroblast nemosis induces angiogenic responses of endothelial cells. Exp Cell Res. 2010;316:826-35.

Guse K, Sloniecka M, Diaconu I, Ottolino-Perry K, Tang N, Ng C, Le Boeuf F, Bell JC, McCart JA, Ristimäki A, Pesonen S, Cerullo V, Hemminki A. Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models. J Virol. 2010;84:856-66.

Hamer G, Matilainen O, Holmberg CI. A photoconvertible reporter of the ubiquitin-proteasome system in vivo. Nature Methods. 2010;7:473-8.

Hölttä-Vuori M, Salo TV, Nyberg L, Brackmann C, Enejder A, Panula P, and Ikonen E (2010) Zebrafish: gaining popularity in lipid research. Biochem J. 2010: 429: 235-242.

Jäämaa S, Af Hällström TM, Sankila A, Rantanen V, Koistinen H, Stenman UH, Zhang Z, Yang Z, De Marzo AM, Taari K, Ruutu M, Andersson LC, Laiho M. DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue. Cancer Res. 2010;70:8630-41.

Kaivosoja E, Myllymaa S, Kouri VP, Myllymaa K, Lappalainen R, Konttinen YT. Enhancement of silicon using micro-patterned surfaces of thin films. Eur Cell Mater. 2010;19:147-57.

Lavilla-Alonso S, Bauerschmitz G, Abo-Ramadan U, Halavaara J, Escutenaire S, Diaconu I, Tatlisumak T, Kanerva A, Hemminki A, Pesonen S. Adenoviruses with an avß integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases. J Transl Med. 2010;8:80.

Leppäranta O, Pulkkinen V, Koli K, Vähätalo R, Salmenkivi K, Kinnula VL, Heikinheimo M, Myllärniemi M. Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2010;42:626-32.

Myllymaa S, Kaivosoja E, Myllymaa K, Sillat T. Korhonen H, Lappalainen R, Konttinen YT. Adhesion, spreading and osteogenic differentiation of mesenchymal stem cells cultured on micropatterned diamond, titanium, tantalum and chromium coating. J Mater Sci Mater Med. 2010;21:329-41.

Norrmén C, Vandevelde W, Ny A, Saharinen P, Gentile M, Haraldsen G, Puolakkainen P, Lukanidin E, Dewerchin M, Alitalo K, Petrova TV. Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Blood. 2010;115:906-9.

Pedrono E, Durukan A, Strbian D, Marinkovic I, Shekhar S, Pitkonen M, Abo-Ramadan U, Tatlisumak T. An optimized mouse model for transient ischemic attack. J Neuropathol Exp Neurol. 2010;69:188-95.

Poduval P, Sillat T, Virtanen I, Dabagh-Meshin M, Konttinen YT. Immigration check for neutrophils in RA lining: laminin α5 low expression regions act as exit point. Scand J Rheumatol. 2010;39:132-40.

Rajamäki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, Kovanen PT, Eklund KK. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One. 2010;5:e11765.

Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K. Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Gene Dev. 2010; 24: 875-80.

Sarek G, Järviluoma A, Moore HM, Tojkander S, Vartia S, Biberfeld P, Laiho M, Ojala PM. Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PLoS Pathog. 2010;6:e1000818.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K. FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci USA. 2010;107:15786-91.

Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Ingvarsen S, Engelholm LH, Kallioniemi O, Alitalo K, Taipale J, Keski-Oja J, Lehti K. FGF receptor-4 regulates tumor invasion by coupling FGF-signaling to extracellular matrix degradation. Cancer Res. 2010;70:7851-61.

Takkunen M, Hukkanen M, Liljeström M, Grenman R, Virtanen I. Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia. J Cell Mol Med. 2010;14:1569-93.

Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell. 2010;18:630-40.

Uronen RL, Lundmark P, Orho-Melander M, Jauhiainen M, Larsson K, Siegbahn A, Wallentin L, Zethelius B, Melander O, Syvänen AC, Ikonen E. Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels. Arterioscler Thromb Vasc Biol. 2010;30:1614-20.

Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, Yan D, Olkkonen VM. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. Exp Cell Res. 2010;316:3304-16.

Zou J, Zhang W, Poe D, Zhang Y, Ramadan UA, Pyykkö I. Differential passage of gadolinium through the mouse inner ear barriers evaluated with 4.7 T MRI. Hear Res. 2010;259:36-43.

Zou J, Ramadan UA, Pyykkö I. Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane. Otol Neurotol. 2010;31:637-41.

Zou J, Sood R, Ranjan S, Poe D, Ramadan UA, Kinnunen PK, Pyykkö I. Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium. J Nanobiotechnology. 2010;18:8:32.

Zou J, Zhang W, Poe D, Qin J, Fornara A, Zhang Y, Ramadan UA, Muhammed M, Pyykkö I. MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear. Nanomedicine (Lond). 2010;5:739-54.

Abo-Ramadan U, Durukan A, Pitkonen M, Marinkovic I, Tatlisumak E, Pedrono E, Soinne L, Strbian D, Tatlisumak T. Post-ischemic leakiness of the blood-brain barrier: A quantitative and systematic assessment by Patlak plots. Exp Neurol. 2009;219:328-33.

Ainola M, Li TF, Mandelin J, Hukkanen M, Choi SJ, Salo J, Konttinen YT. Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. Ann Rheum Dis. 2009;68:427-34.

Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen VM, Jeltsch M, Ylä-Herttuala S, Alitalo K. Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res. 2009;104:1302-12.

Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF, Koskinen PJ, Taipale J, Ojala PM. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathog. 2009;5:e1000324.

Durukan A, Marinkovic I, Strbian D, Pitkonen M, Pedrono E, Soinne L, Abo-Ramadan U, Tatlisumak T. Post-ischemic blood-brain barrier leakage in rats: one-week follow-up by MRI. Brain Res. 2009;1280:158-65.

Koski A, Rajecki M, Guse K, Kanerva A, Ristimäki A, Pesonen S, Escutenaire S, Hemminki A. Systemic adenoviral gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and Kupffer cells. J Gene Med. 2009;11:966-77.

Lehti K, Rose N, Valavaara S, Weiss SJ, Keski-Oja J. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. J Cell Science. 2009;122:126-35.

Linden AM, Johnson BG, Trokovic N, Korpi ER, Schoepp DD. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology. 2009;57:172-82.

Linder MD, Mäyränpää MI, Peränen J, Pietilä TE, Pietiäinen VM, Uronen RL, Olkkonen VM, Kovanen PT, Ikonen E. Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages. Arterioscler Thromb Vasc Biol. 2009;29:883-8.

Marincovic I, Strbian D, Pedrono E, Vekovischeva O, Shekhar S, Durukan A, Korpi E, Abo-Ramadan U, Tatlisumak T. Decompressive craniectomy for intracerebral hemorrhage: the earlier the better. Neurosurgery. 2009;65:780-6.

Marjamaa J, Tulamo R, Frösen J, Abo-Ramadan U, Hernesniemi J, Niemelä M, Kangasniemi M. Occlusion of neck remnant in experimental rat aneurysms after treatment with platinum or PGLA-coated coils. Surg Neurol. 2009;71:458-65.

Norrmén C, Ivanov K, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin H, Ylä-Herttuala S, Alitalo K, Petrova T. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biology. 2009;185:439-57.

Perttilä J, Merikanto K, Naukkarinen J, Surakka I, Martin NW, Tanhuanpää K, Grimard V, Taskinen MR, Thiele C, Salomaa V, Jula A, Perola M, Virtanen I, Peltonen L, Olkkonen VM. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. J Mol Med. 2009; 87:825-35.

Poduval P, Sillat T, Virtanen I, Porola P, KonttinenYT. Abnormal basement membrane type IV collagen alpha chain composition in labial salivary glands in Sjögren’s syndrome. Arthritis Rheum. 2009;60:938-45, 2009.

Poe D, Zou J, Zhang W, Qin J, Ramadan UA, Fornara A, Muhmmed M, Pyykkö I. MRI of the cochlea with superparamagnetic iron oxide nanoparticlescompared to Gadolinium chelate contrast agents in a rat model. Eur J Nanomedicine. 2009;2:29-36.

Rajecki M, af Hällström T.M, Hakkarainen T, Nokisalmi P, Hautaniemi S, Nieminen A.I, Tenhunen M, Desmond R.M, Chen D.T, Guse K, Stenman U-H, Gargini R, Kapanen M, Klefström J, Kanerva A, Pesonen S, Hemminki A. Mre11 Inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. Int J Cancer. 2009;125:2441-9.

Sallinen V, Torkko V, Sundvik M, Reenilä I, Khrustalyov D, Kaslin J, Panula P. MPTP and MPP+ target specific aminergic cell populations in larval zebrafish. J Neurochem. 2009;108:719-31.

Sillat T, Pöllänen R, Lopes JRC, Porola P, Ma G, Korhonen M, Konttinen YT. Intracrine androgenic apparatus in human bone marrow stromal cells. J Cell Mol Med. 2009;13:3296-3302.

Sobota JA, Bäck N, Eipper BA, Mains RE. Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. J Cell Sci. 2009;122:3542-53.

Spaan M, Porola P, Laine M, Rozman B, Azuma M, Konttinen YT. Healthy human salivary glands contain a DHEA-sulphate processing intracrine machinery, which is deranged in primary Sjögren’s syndrome. J Cell Mol Med. 2009;13:1261-70.

Vuoristo S, Virtanen I, Takkunen M, Palgi J, Kikkawa Y, Rousselle P, Sekiguchi K, Tuuri T, Otonkoski T. Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support. J Cell Mol Med. 2009;13:2622-33.

Ahola S, Myllytie P, Österberg M, Teerinen T, Laine J. Effect of polymer adsorption on cellulose nanofibril water binding capacity and aggregation. Bio Res. 2008;3:1315-28.

Ainola M, Valleala H, Nykänen P, Risteli J, Hanemaaijer R, Konttinen YT. Erosive arthritis in a patient with pycnodysostosis: an experiment of nature. Arthritis Rheum. 2008;58:3394-401.

Beklen A, Hukkanen M, Richardson R, Konttinen YT. Immunohistochemical localization of toll-like receptors 1-10 in periodontitis. Oral Microbiol Immunol. 2008;23:425-31.

Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol. 2008;84:701-12.

Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA, Achen MG, Alitalo K. Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol. 2008;28:4843-50.

Hölttä-Vuori M, Uronen RL, Repakova J, Salonen E, Vattulainen I, Panula P, Li Z, Bittman R, Ikonen E. BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms. Traffic. 2008;9:1839-49.

Jacobs S, Ruusuvuori E, Sipilä ST, Haapanen A, Damkier HH, Kurth I, Hentschke M, Schweizer M, Rudhard Y, Laatikainen LM, Tyynelä J, Praetorius J, Voipio J, Hübner CA. Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci USA. 2008;8;105:311-6.

Jansen M, Pietiäinen VM, Pölönen H, Rasilainen L, Koivusalo M, Ruotsalainen U, Jokitalo E, Ikonen E. Cholesterol substitution increases the structural heterogeneity of caveolae. J Biol Chem. 2008;283:14610-8.

Kantola A, Keski-Oja J, Koli K. Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion. Exp Cell Res. 2008;314:2488-500.

Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, Oresic M, Alitalo K. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res. 2008;103:1018-26.

Koli K, Ryynänen M, Keski-Oja J. Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells. Bone. 2008;43:679-88.

Laine M, Virtanen I, Porola P, Rotar Z, Rozman B, Poduval P, Konttinen YT. Acinar epithelial cell laminin-receptors in labial salivary glands in Sjögren’s syndrome. Clin Exp Rheumatol. 2008;26:807-13.

Latonen L, Järvinen PM, Laiho M. Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death. Exp Cell Res. 2008;314:738-47.

Laulajainen M, Muranen T, Carpén O, Grönholm M. Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton. Oncogene. 2008;27:3233-43.

Lyly A, Marjavaara SK, Kyttälä A, Uusi-Rauva K, Luiro K, Kopra O, Martinez LO, Tanhuanpää K, Kalkkinen N, Suomalainen A, Jauhiainen M, Jalanko A. Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism. Hum Mol Genet. 2008;17:1406-17.

Mattila J, Kallijärvi J, Puig O. RNAi screening for kinases and phosphatases identifies FoxO regulators. Proc Natl Acad Sci USA. 2008;105:14873-8.

Otonkoski T, Banerjee M, Korsgren O, Thornell LE, Virtanen I. Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation. Diabetes Obes Metab. 2008;10 Suppl 4:119-27.

Partanen S, Haapanen A, Kielar C, Pontikis C, Alexander N, Inkinen T, Saftig P, Gillingwater TH, Cooper JD, Tyynelä J. Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis. J Neuropathol Exp Neurol. 2008;67:16-29.

Reijonen S, Putkonen N, Nørremølle A, Lindholm D, Korhonen L. Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins. Exp Cell Res. 2008;314:950-60.

Strbian D, Durukan A, Pitkonen M, Marinkovic I, Tatlisumak E, Pedrono E, Abo-Ramadan U, Tatlisumak T. The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia. Neuroscience. 2008;153:175-81.

Takkunen M, Ainola M, Vainionpää N, Grenman R, Patarroyo M, García de Herreros A, Konttinen YT, Virtanen I. Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells. Histochem Cell Biol. 2008;130:509-25.

Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature. 2008;454:656-60.

Varjosalo M, Björklund M, Cheng F, Syvänen H, Kivioja T, Kilpinen S, Sun Z, Kallioniemi O, Stunnenberg HG, He WW, Ojala P, Taipale J. Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell. 2008;133:537-48.

Vilen ST, Nyberg P, Hukkanen M, Sutinen M, Ylipalosaari M, Bjartell A, Paju A, Haaparanta V, Stenman UH, Sorsa T, Salo T. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. Exp Cell Res. 2008;314:914-26.

Virtanen I, Banerjee M, Palgi J, Korsgren O, Lukinius A, Thornell LE, Kikkawa Y, Sekiguchi K, Hukkanen M, Konttinen YT, Otonkoski T. Blood vessels of human islets of Langerhans are surrounded by a double basement membrane. Diabetologia. 2008;51:1181-91.

Väänänen AJ, Salmenperä P, Hukkanen M, Miranda KM, Harjula A, Rauhala P, Kankuri E. Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide. Free Radic Biol Med. 2008;45:749-55.

Beklen A, Ainola M, Hukkanen M, Gürgan C, Sorsa T. Konttinen YT. MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis. J Dent Res. 2007;86:347-51.

Haapanen A, Ramadan UA, Autti T, Partanen S, Joensuu R, Saftig P, Tyynelä J. In vivo MRI reveals severe atrophy and signal intensity changes in the brains of the cathepsin D knock-out mice. Magn Reson Imaging. 2007;25:1024-31.

Kiviharju-af Hällström TM, Jäämaa S, Mönkkönen M, Peltonen K, Andersson LC, Medema RH, Peehl DM, Laiho M. Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement. Proc Natl Acad Sci USA. 2007;104:7211-16.

Koivusalo M, Jansen M, Somerharju P, Ikonen E. Endocytic trafficking of sphingomyelin depends on its acyl chain length. Mol Biol Cell. 2007;18:5113-23.

Koopal S, Furuhjelm JH, Järviluoma A, Jäämaa S, Pyakurel P, Pussinen C, Wirzenius M, Biberfeld P, Alitalo K, Laiho M, Ojala PM. Viral oncogene-induced DNA damage response is activated in Kaposi’s sarcoma tumorigenesis. PLoS Pathogens. 2007;3:1348-60.

Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel M, Segil N, Pirvola U. p19Ink4d and p21Cip1 collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J Neuroscience. 2007;27:1434-44.

Linder MD, Uronen RL, Hölttä-Vuori M, van der Sluijs P, Peränen J, Ikonen E. Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells. Mol Biol Cell. 2007;18:47-56.

Muranen T, Grönholm M, Lampin A, Lallemand D, Zhao F, Giovannini M, Carpén O. The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton. Hum Mol Genet. 2007;16:1742-51.

Nieminen AI, Partanen JI, Hau A, Klefstrom J. c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J. 2007;26:1055-67.

Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA. 2007;104:14694-9.

Poduval P, Sillat T, Beklen A, Kouri VP, Virtanen I, Konttinen YT. Type IV collagen a-chain composition in normal and arthritic synovial lining. Arthritis Rheum. 56:3959-67.

Sarek G, Kurki S, Enbäck J, Iotzova G, Haas J, Laakkonen P, Laiho M, Ojala PM. Therapeutic potential of small-molecule inhibitor of the p53-Mdm2 interaction in primary erffusion lymphomas. J Clin Invest. 2007;117:1019-28.

Strbian D, Tatlisumak T, Ramadan UA, Lindsberg PJ. Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab. 2007;27:795-802.

Tammela T, Saaristo A, Holopainen T, Lyytikkä J, Kotronen A, Pitkonen M, Abo-Ramadan U, Ylä-Herttuala S, Petrova TV, Alitalo K. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nat Med. 2007;13:1458–66.

Taskinen M, Karjalainen-Lindsberg M-L, Nyman H, Eerola L-M, Leppä S. A high tumor-associated macrophage content predicts favourable outcome in follicular lymphoma patients treated with rituximab and CHOP. Clin Cancer Res. 2007;13:5784-89.

Vainionpää N, Bützow R, Hukkanen M, Jackson DG, Pihlajaniemi T, Sakai LY, Virtanen I. Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomas. Cell Tissue Res. 2007;328:317-28.

Vainionpää N, Lehto VP, Tryggvason K, Virtanen I. Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function. Lab Invest. 2007;87:780-91.

Willberg J, Hormia M, Takkunen M, Kikkawa Y, Sekiguchi K, Virtanen I. Lutheran blood group antigen as a receptor for alpha5 laminins in gingival epithelia. J Periodontol. 2007;78:1810-8.

Francí C, Takkunen M, Dave N, Alameda F, Gómez S, Rodríguez R, Escrivà M, Montserrat-Sentís B, Baró T, Garrido M, Bonilla F, Virtanen I, García de Herreros A. Expression of Snail protein in tumor-stroma interface. Oncogene. 2006; 25:5134-44.

Frösen J, Marjamaa J, Myllärniemi M, Abo-Ramadan U, Tulamo R, Niemelä M, Hernesniem J, Jääskeläinen J. Contribution of mural and bone marrow-derived neointimal cells to thrombus organization and wall remodeling in a microsurgical murine saccular aneurysm model. Neurosurgery. 2006;58:936-44.

Grönholm M, Muranen T, Toby GG, Utermark T, Hanemann CO, Golemis EA, Carpén O. A functional association between merlin and HEI10, a cell cycle regulator. Oncogene. 2006;25:4389-98.

Gürpinar ÖA, Beklen A, Hukkanen M, Cehreli ZC, Onur MA, Konttinen YT. Effects of two multi-step self-etch primer/adhesives on apoptosis in human gingival fibroblasts in vitro. J Biomed Mat Res Part B - Appl Biomat. 2006;79:435-40.

Karvonen U, Jänne OA, Palvimo JJ. Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. Exp Cell Res .2006;312:3165-83.

Katz S, Hukkanen M, Lounatmaa K, Rousselle P, Tervo T, Virtanen I. Cooperation of isoforms of laminin-332 and tenascin-CL during early adhesion and spreading of immortalized human corneal epithelial cells. Exp Eye Res. 2006;83:1412-22.

Ma GF, Liljeström M, Ainola M, Chen T, Tiainen VM, Lappalainen R, Konttinen YT, Salo J: Expression of ADAM9 (meltrin-?) around aseptically loosened total hip replacement implants. Rheumatology. 2006;45:808-14.

Marjamaa J, Tulamo R, Abo-Ramadan U, Hakovirta H, Frösen J, Rahkonen O, Niemelä M, Bornstein P, Penttinen R, Kangasniemi M. Mice with a deletion in the first intron of the Col1a1 gene develop dissection and rupture of aorta in the absence of aneurysms: high-resolution magnetic resonance imaging, at 4.7 T, of the aorta and cerebral arteries. Magn Reson Med. 2006;55:592-7.

Ruuttila P, Niiranen H, Kellomäki M, Törmälä P, Konttinen YT, Hukkanen M. Characterization of human primary osteoblast response on bioactive glass (BaG13-93)- coated poly-L,DL-lactide (SR-PLA70) surface in vitro. J Biomed Mater Res B Appl Biomater. 2006;78:97-104.

Saaristo A, Tammela T, Färkkilä A, Kärkkäinen M, Suominen E, Ylä-Herttuala S, Alitalo A. Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol. 2006;169:1080-87.

Takkunen M, Grenman R, Hukkanen M, Korhonen M, García de Herreros A, Virtanen I. Snail-dependent and -independent epithelial-mesenchymal transition in oral squamous carcinoma cells. J Histochem Cytochem. 2006;54:1263-75.

Vainio S, Jansen M, Koivusalo M, Róg T, Karttunen M, Vattulainen I, Ikonen E. Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. J Biol Chem. 2006;281:348-55.

Vainionpää N, Kikkawa Y, Lounatmaa K, Miner JH, Rousselle P, Virtanen I. Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am J Physiol Cell Physiol. 2006;290:C764-75.

Väänänen AJ, Salmenperä P, Hukkanen M, Rauhala P, Kankuri E. Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages. Free Radic Biol Med. 2006;41:120-31.

Hasenson S, Määttä M, Rousselle P, Kikkawa Y, Miner JH, Tervo T, Virtanen I. The immortalized human corneal epithelial cells adhere to laminin-10 by using Lutheran glycoproteins and integrin alpha3beta1. Exp Eye Res. 2005; 81:415-21.

Hölttä-Vuori M, Alpy F, Tanhuanpää K, Jokitalo E, Mutka AL, Ikonen E. MLN64 is involved in actin-mediated dynamics of late endocytic organelles. Mol Biol Cell. 2005;16:3873-86.

Konttinen YT, Ma J, Ruuttila P, Hukkanen M, Santavirta S. Chondrocyte-mediated collagenolysis correlates with cartilage destruction grades in osteoarthritis. Clin Exp Rheumatol. 2005;23:19-26.

Konttinen YT, Tensing EK, Laine M, Porola P, Törnwall J, Hukkanen M. Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjögren's syndrome. J Rheumatol. 2005;32:1071-5.

Ma GF, Ainola M, Liljeström M, Santavirta S, Poduval P, Zhao D, Chen T, Konttinen YT. Increased expression and processing of ADAM 12 (meltrin-a) in osteolysis associated with aseptic loosening of total hip replacement implants. J Rheumatol. 32:1943-50, 2005.

Mandelin J, Liljeström M, Li TF, Ainola M, Hukkanen M, Salo J, Santavirta S, Konttinen YT. Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation. J Biomed Mater Res B Appl Biomater. 2005;74:582-8.

Muranen T, Grönholm M, Renkema GH, Carpén O. Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin. Oncogene. 2005;24:1150-8.

Peltonen K, Kiviharju T, Järvinen P, Ra R, Laiho M. Histone deacetylase inhibitor provokes p53 independent cell cycle arrest and apoptosis in melanoma cell lines. Pigment Cell Res. 2005;18:196-202.

Rigamonti E, Helin L, Lestavel S, Mutka A-L, Lepore M, Fontaine C, Bouhlel MA, Bultel S, Fruchart JC, Ikonen E, Clavey V, Staels B, and Chinetti-Gbaguidi G. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ Res. 2005;97: 682-689.

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