• High Throughput Biomedicine Unit provides assay-ready drug plates for those customers who needs to run their assays in their own laboratory.
  • Customers may choose either an existing drug set from our collection or cherry-pick selected drugs.
  • Drugs are placed into assay plates using our ultrasound-driven ECHO dispencers and stored at low oxygen and humidity under nitrogen gas in storage pods for up to 30 days.
  • Sealed plates can be sent to remote locations by post.
  • Drug Sensitivity and Resistance Testing (DSRT) platform enables doctors and researchers to test effects of large numbers of pharmacological compounds in primary or established cell lines of their choice.
  • Doctors use DSRT as part of the Individualized Systems Medicine (ISM) program in which primary cells freshly isolated from cancer patients are being tested for sensitivity to a set of approved or experimental drugs. This approach helps doctors to choose the best treatment for a given individual cancer patient at a given time.
  • Researchers use DSRT as a chemical tool to explore functional properties,  identify candidate therapeutic targets and relevant pathways in their cellular models.

*** The DSRT is primarily for research purposes. It is not (yet) approved for clinincal use and remains experimental in nature. All tests on patients' material should be initiated through patient's primary point of care and only his/her doctor can interpret the DSRT results and make the decision on the most suitable treatment option.

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  • HTB unit houses several collections of chemical libraries and instrumentation needed to process large numbers of samples in a high throughput fashion.
  • Our platforms allow for plate-based biochemical and cell-based screening.
  • We support both plate reader assays and high content microscopy.
  • All projects are customized to individual project's needs.
  • If you are interested in doing a high throughput screening with us, complete the online project contact form and we will contact you to discuss it further.
  • High throughput flow cytometry helps to test antibody cross-reactivity with multiple antigens or drug effects on multiple cell subpopulations in complex cell mixtures such as blood.
  • ECHO liquid dispencers allow for efficient and economical use of antibodies by accurately dispensing only nanolitres of undiluted antibodies at a time.

 

With technical questions concerning HT flow cytometry contact Tanja Ruokoranta.

Tanja
Ruokoranta
Laboratory Coordinator
Institute for Molecular Medicine Finland
Field of science Biochemistry, cell and molecular biology, Plant biology, microbiology, virology, Genetics, developmental biology, physiology, Cancers, Medical biotechnology, Chemical sciences
  • Our diverse liquid handling instruments (pipetting robots, ECHO- peristaltic- and other types of liquid dispencers) allow for fast and accurate dispensing of tiny volumes (as low as 2.5 nl) of various liquids (aqueous solutions, DMSO, antibodies, cell suspensions).
  • Our robotics can help customers to significantly scale-up their experiments and save time and money at the same time by using small reaction volumes (e.g. qPCR in 2 uL) and multi-well (384- and 1536-well) microplates.
  • High throughput flow cytometry helps to test antibody cross-reactivity with multiple antigens or drug effects on multiple cell subpopulations in complex cell mixtures such as blood.
  • The core maintains the Ambion Silencer Select V4-library and houses instruments needed to process a large amount of samples in high throughput fashion.
  • Our platforms enable genome-wide, sub-library or candidate gene screens.