PROGRAMME, the 59th ICBL conference
’Lipid Fluxes and Metabolism – From Fundamental Mechanisms to Human Disease’
Sept 4-7, 2018, Helsinki, Finland
Tuesday, Sept 4
16-18 Registration
18.00 Laszlo Vigh, President of the ICBL organization: Opening of the Conference
18.05 Vesa Olkkonen, Helsinki: Introduction of the Laurens Van Deenen Lecturer
18.10 The Laurens Van Deenen lecture of 2018: Rosalind Coleman (Chapel Hill, NC) – Compartmentalization of fatty acid metabolism and lipid pathways; Supported by Elsevier - BBA Molecular and Cell Biology of Lipids
19.30 Welcome reception
Wednesday, Sept 5
8.30-11.40 Session I. Lipid-induced modulation of protein function
Chairs: Andrew Brown (Sydney, Australia) and Christophe Lamaze (Paris, France)
8.30-9.10 Christian Eggeling (Oxford) - Super-resolution microscopy studies of molecular membrane dynamics
9.10-9.50 Christophe Lamaze (Paris) - Receptor glycosylation, galectins and lipid nanodomains: the key triad in JAK/STAT activation by IFN-gamma
9.50-10.10 Kecheng Zhou (Helsinki, Finland) - A ceramide-regulated element in the late endosomal protein LAPTM4B controls its amino acid transporter interaction
10.10-10.40 Coffee and poster viewing
10.40-11.20 Mark Sansom (Oxford) – Molecular dynamics simulations of membrane proteins and their interactions: from nanoscale to mesoscale
11.20-11.40 Natalia Krupenko (Chapel Hill, NC, USA) - Activation of p53 by direct binding of C16-ceramide as a stress-response mechanism
11.40-12.40 LUNCH and poster viewing
12.40-15.00 Session II. Inter-organelle lipid trafficking
Chairs: Tim Levine (London, UK) and Vesa Olkkonen (Helsinki, Finland)
12.40-13.20 Tim Levine (London) - Membrane contact sites in inter-organelle lipid transport
13.20-14.00 Bruno Mesmin (Valbonne) - Spatiotemporal coupling between cholesterol transport and PI(4)P turnover at ER/TGN contact sites
14.00-14.20 Cécile Bandet (Inserm, France) - The ceramide transporter CERT is involved in muscle insulin signaling defects under lipotoxic conditions
14.20-14.40 Joe Costello (Exeter, UK) - Inter-organelle lipid trafficking between the endoplasmic reticulum and peroxisomes
14.40-15.00 Osamu Kuge (Kyushu, Japan) - Novel functions of porin proteins in mitochondrial phospholipid metabolism
15.00-17.00 Coffee and Poster session I (ICBL Steering Committee meeting at 15.15-16.30)
17.00-19.50 Session III. Regulation of lipid synthesis, catabolism and storage
Chairs: Gary Lewis (Toronto, Canada) and Matti Jauhiainen (Helsinki, Finland)
17.00-17.40 Gary Lewis (Toronto) - Regulation of Lipid Mobilization and Lipoprotein Production by the Intestine; Supported by Elsevier - Chemistry and Physics of Lipids
17.40-18.00 Andrew Brown (Sydney, Australia) - A conserved degron and cholesterol-responsive spring control a key enzyme in cholesterol synthesis
18.00-18.20 Yusuke Ohno (Hokkaido, Japan) - ABHD5 cooperates with PNPLA1 to produce acylceramides
18.20-18.50 Refreshments
18.50-19.30 Toyoshi Fujimoto (Nagoya) – Nuclear lipid droplets: how they form and what they do in hepatocytes
19.30-19.50 Sophia Tsouka (EPFL, Switzerland) - Mapping the diverse phenotypic states of yeast lipid metabolism to enzymes using mechanistic kinetic models
Thursday, Sept 6
9.00-12.20 Session IV. Novel lipid probes for studying lipid transport and metabolism
Chairs: Luis Loura (Coimbra, Portugal) and Elina Ikonen (Helsinki, Finland)
9.00-9.40 Christer Eijsing (SDU/EMBL) - Functional lipidomics - technology and
applications for systems-level analysis of lipid metabolism
9.40-10.00 Nicolas Vitale (CNRS, France) - Novel PA sensors and lipidomics reveal PA dynamics during phagocytosis
10.00-10.20 Shin-ya Morita (Shiga, Japan) - Novel enzymatic fluorometric measurements of all major cellular phospholipid classes
10.20-11.20 Coffee and poster viewing
11.20-12.00 Luis Loura (Coimbra) – How probes gauge and affect the structure and dynamics of membranes - Atomistic view
12.00-12.20 Josef Ecker (Münich, Germany) - Gut microbiota-derived short chain fatty acids are precursors for hepatic lipid synthesis
12.20-13.20 LUNCH and poster viewing
13.30-18.30 Social programme/Excursion to the Suomenlinna Sea Fortress
19.30 Conference dinner – Restaurant Meripaviljonki/Sea Pavillon
Friday, Sept 7
8.30-11.40 Session V. Lipids in inflammation
Chairs: Nicolas Flamand (Quebec City, Canada) and Saara Laitinen (Helsinki, Finland)
8.30-9.10 Charles Serhan (Harvard) - Novel Resolvin Conjugates in Tissue Regeneration (RCTRs): RCTR1-3 identification in human tissues and proresolving functions
9.10-9.30 Yuta Shimanaka (Tokyo, Japan) - Omega-3 Fatty Acid Epoxides Control the Magnitude of IgE-mediated Mast Cell Activation
9.30-9.50 Catherine Mounier (Quebec, Canada) - Non-inflammatory hepatic steatosis in a mouse model overexpressing the lipocalin ApoD
9.50-10.20 Coffee
10.20-11.00 Nicolas Flamand (Quebec City) - Regulation of inflammation by endocannabinoids and their metabolites
11.00-11.20 Maria A. Balboa (Valladolid, Spain) - LPIN2 mutations promote Majeed´s Syndrome by activating the NLRP3 inflammasome
11.20-11.40 Takehiko Yokomizo T (Juntendo, Japan) - Roles of Leukotriene B4 receptors BLT1 and BLT2 in vivo
11.40-12.30 LUNCH
12.30-14.00 Poster session II
14.00-17.50 Session VI. Lipids as markers for health and disease
Chairs: Gerhard Liebisch (Regensburg, Germany) and Shinji Yokoyama (Chubu, Japan)
14.00-14.40 Markus Wenk (Singapore) - Translation of lipidomic technologies towards quatification of blood lipids and their natural variations
14.40-15.00 Shinji Yokoyama (Chubu, Japan) - Bioinformatic Analysis of HDL Components Differentiated Structure and Function of apoA-II-associated and –unassociated HDL
15.00-15.20 Maija Ruuth (Helsinki, Finland) - Susceptibility of LDL particles to aggregate is reduced by PCSK9 inhibitor and by healthy diet
15.20-15.40 Gabor Tigyi (Memphis, USA) - Regulation of the Cancer Stem Cell - Tumor Microenvironment Interaction by the Autotaxin-LPA Receptor Axis
15.40-16.10 Coffee
16.10-16.50 Daniel Ory (St. Louis) - Identification of Niemann-Pick C disease biomarkers through metabolomic screening
16.50-17.10 Gabor Balogh (Szeged, Hungary) Cerebrospinal fluid lipids in neurological disorders: special focus on Alzheimer's disease and Guillain-Barré syndrome
17.10-17.30 Fanny Pilot-storck (IMRB, France) - Lipid-dependent modulation of muscle mitochondrial membranes protects against diet induced obesity
17.30-17.50 Kim Ekroos (Helsinki, Finland) and Gerhard Liebisch (Regensburg, Germany) – Introduction of the Lipidomics Standards Initiative (LSI)
17.50-18.20
Presentation of the 60th ICBL conference
Prof. Markus Wenk delivers the J Lipid Res Junior Investigator Award
Young Investigator awards for oral and poster presentations
Closing of the symposium