The development of algorithms to well-defined problems, mathematical exact method, and computational modeling characterize the approaches to tackle difficult problems in this research area. Some of the researchers focus on theoretical aspects of computation, some focus on more practical algorithm engineeering and optimization, and some focus on tailoring algorithms to problems arising from bioinformatics. Specific research areas under study are algorithmic approaches to artificial intelligence and machine learning, exact algorithms for NP-hard problems, string processing and sequence analysis algorithms, succinct data structures, and modeling of biological systems such as evolution.