We aim at discovering new ways to treat heart diseases by investigating the molecular mechanisms of genetic cardiac diseases as well as cardiac regeneration and remodelling, and thereby identifying potential new drug targets. We are interested in three cell types: cardiomyocytes, i.e. heart muscle cells, fibroblasts, and vascular endothelial cells. We aim to find ways to promote cardiomyocyte renewal after a myocardial infarction and strategies to inhibit pathological cardiac remodelling: hypertrophy (thickening) and fibrosis (stiffening). We develop, screen and characterise new compounds with potential to enhance the regenerative capacity of the heart or to inhibit cardiac remodelling.