Pedro Esbrit
Graduated in Chemistry and Biochemistry in 1974 from Universidad Complutense in Madrid, Spain. Ph.D. in Biochemistry from Universidad Autónoma de Madrid in 1980.
Biochemistry teacher in the Department of Biology at University School Luis Vives- Centro de Estudios Universitarios in Madrid 1973-8.
Fulbright post-doc fellow in the Renal Division at Barnes and Jewish Hospitals in St. Louis, MO, USA during 1981-2.
Associate professor at Fundación Jiménez Díaz since 1991.
Visiting researcher at the Veterans Administration Hospital and Yale University in New Haven, CT, USA, during 1988 and 1994.
Research Director at Fundación Jiménez Díaz 2003.
He is currently Head of Bone and Mineral Metabolism Laboratory at The Instituto de Investigación Sanitaria-Fundación Jiménez Díaz in Madrid.
PI of 21 research grants since 1985.
Has published 96 in peer-reviewed international journals on metabolic studies involving renal and bone growth factors, particularly focused on the actions of parathyroid hormone-related protein.
Invited speaker in international meetings in the field of bone and mineral metabolism.
Paper reviewer for several international journals, including Kidney International, Journal of American Society of Nephrology, Journal of Bone and Mineral Research and Bone.
Supervisor of post-graduate and Ph.D. students in programs related to bone and mineral metabolism.
Opponent and member of examination committee for Ph.D. dissertations.
Enrique Gómez Barrena
M.D., 1987, Universidad de Zaragoza, Spain. Ph.D., 1992, Universidad Autónoma de Madrid, Spain. Internship and Residency in Orthopaedic Surgery, 1987-92, Hospital “La Paz”, Madrid, Spain.
Orthopaedic Research Fellowship, 1994, Hospital for Special Surgery, New York, NY
E.C.F.M.G. (Educational Comission for Foreign Medical Graduates, Philadelphia, Pennsylvania, U.S.A.) Certification, january 1994; T.O.E.F.L. (Test of English as a Foreign Language), april 1993.
Staff Orthopaedic Surgeon, Hospital “La Paz”, Madrid, Spain, 1993, 1995-1996. Hospital “Ntra. Sra. De Gracia”, Zaragoza, Spain, 1996-2000. Staff Orthopaedic Surgeon, Fundación “Jiménez Díaz” Hospital, Madrid, Spain, since 2000.
Associated Chief, Orthopaedic Surgery, Fundación “Jiménez Díaz” Hospital, Madrid, Spain, since 2007.
Assistant Professor, Universidad Autónoma de Madrid, 1996
Associate Permanent Professor of Orthopaedic Surgery, Universidad Autónoma de Madrid, since 2000.
Full Professor, Orthopaedic Surgery, since 2007.
Vice-Dean, Universidad Autónoma de Madrid Medical School, since 2004 Involved in 15 research grants (Spanish National Agencies, European Union 7th Frame Program), Management Committee of 537-EU COST action, and Steering Board of REMEDIC EU network (European Science Foundation). Working Package leader, Collaborative Project FP7-HEALTH-2009-1.4-2 “REBORNE: Regenerating Bone defects using New biomedical Engineering approaches”.
Bone and Mineral Metabolism Laboratory Group
 
Pedro Esbrit (PhD); Enrique Gómez-Barrena (MD, PhD)
    
From left to right: Adela García-Martín (PhD); Daniel Lozano (PhD); Sergio Portal-Núñez (PhD); Ana López-Herradon (PhD student); Marta Maycas (PhD student)
Current collaborations
Dr. M. Vallet-Regí. Departamento de Química Inorgánica y Bioinorgánica. Facultad de Farmacia. Universidad Complutense de Madrid.
Dr. J. Buján. Departamento de Especialidades Médicas. Facultad de Medicina. Universidad de Alcalá (Madrid).
Dr. A.R. de Gortázar. Departamento de Ciencias Médicas Básicas. Facultad de Medicina. Universidad San Pablo CEU (Madrid).
Dr. A. Díez. Departamento de Medicina Interna. Hospital del Mar (Barcelona).
Selected Recent Publications
V Alonso, AR de Gortázar, JÁ Ardura, I Andrade-Zapata, MV Alvarez-Arroyo, P Esbrit. Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2. J Cell Physiol 217:717-27, 2008.
Esteban J, Gomez-Barrena E, Cordero J, Zamora N, Kinnari TJ, Fernandez-Roblas R. Evaluation of semiquantitative cultures from sonicated retrieved orthopaedic implants in the diagnosis of orthopaedic infection. J Clin Microbiol Feb;46(2):488-92, 2008.
Kinnari T, Soininen A, Esteban J, Zamora N, Alakoski E, Kouri VP, Anttila A, Lappalainen R, Konttinen YT, Gomez-Barrena E, Tiainen VM. Adhesion of Staphylococcal and caco-2 cells on diamond-like carbon polymer hybrid coating. J Biomed Mater Res A Sep;86(3):760-8, 2008.
Virtanen S, Milošev I, Gomez-Barrena E, Trebše R, Salo J, Konttinen YT. Special modes of corrosion under physiological and simulated physiological conditions. Acta Biomater May;4(3):468-76, 2008.
D. Lozano, L.F. de Castro, S. Dapía, I. Andrade-Zapata, F. Manzarbeitia, M. V. Alvarez-Arroyo, E. Gómez-Barrena, P. Esbrit. Role of parathyroid hormone-related protein in the decreased osteoblast function in diabetes-related osteopenia. Endocrinology 150:2027-2035, 2009.
Kinnari TJ, Esteban J, Gomez-Barrena E, Zamora N, Fernandez-Roblas R, Nieto A, Doadrio JC, López-Noriega A, Ruiz-Hernández E, Arcos D, Vallet-Regí M. Bacterial Adherence to SiO2 based multifunctional bioceramics. J Biomed Mater Res A 89: 215-23, 2009.
Martín-de-Hijas N, García-Almeida D, Ayala G, Fernandez-Roblas R, Gadea I, Gómez-Barrena E, Esteban J. Biofilm development by clinical strains of non-pigmented rapidly growing mycobacteria. Clin Microbiol Infect Oct;15(10):931-6, 2009. Epub 2009 Jul 14.
Gómez-Barrena E, Medel FJ, Puértolas JA. Polyethylene Oxidation in Total Hip Arthroplasty: Evolution and New Advances. Open Orthop J Dec 24;3:115-20, 2009.
Lozano D, Manzano M, Doadrio JC, Salinas AJ, Vallet-Regí M, Gómez-Barrena E, Esbrit P.Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater 6: 797-803, 2010.
Fernández de Castro L, Lozano D, Dapía S, Portal-Nuñez S, Caeiro JR, Gomez-Barrena E, Esbrit P. Role of the N- and C-terminal fragments of parathyroid hormone-related protein as putative therapies to improve bone regeneration under high glucocorticoid treatment. Tissue Eng Part A 16: 1157-68, 2010.
Portal-Núñez S, Lozano D, Fernández de Castro L, de Gortázar AR, Nogués X, Esbrit P. Alterations of the Wnt/β-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice. FEBS Lett Jul 16; 584:3095-100, 2010.
C.G. Trejo, D. Lozano, M. Manzano, J.C. Doadrio, A.J. Salinas, S. Dapía, E. Gómez-Barrena, M. Vallet-Regí, N. García-Honduvilla, J. Buján, P. Esbrit. The osteoinductive properties of mesoporous silicate coated with osteostatin in a rabbit femur cavity defect model. Biomaterials Aug 18, 2010. [Epub ahead of print] PMID: 20727584.
Pajarinen J, Cenni E, Savarino L, Gomez-Barrena E, Tamaki Y, Takagi M, Salo J, Konttinen YT. Profile of toll-like receptor-positive cells in septic and aseptic loosening of total hip arthroplasty implants. J Biomed Mater Res A Jul;94(1):84-92, 2010.
Calzado A, Saldaña L, Korhonen H, Soininen A, Kinnari TJ, Gomez-Barrena E, Tiainen VM, Lappalainen R, Munuera L, Konttinen YT, Vilaboa N: In vitro biocompatibility of diamond-like carbon polymer hybrid coatings . Acta BiomaterAug;6(8):3325-38, 2010. |
