Contact Information

Faculty Office:
Viikinkaari 5 E (P.O. Box 56)
00014 University of Helsinki
Phone +358-(0)294 1911 (University)


Flamma intranet

CRS Nordic Chapter
Drug Transport and Delivery Symposium in Helsinki
August 26-27, 2014

This meeting is for scientists, who are interested in drug transport and delivery. The intention of the meeting is to cover a broad aspect of Nordic research activities in the areas poorly soluble drugs, novel drug development technologies, drug transporters and delivery as well as biomolecular drug delivery.

The meeting is an informal and intimate gathering of pharmaceutical scientists both from academia and industry, working in basic and applied pharmaceutical research and in development and manufacturing of drug formulations. The meeting will be organized in conjunction with GPEN 2014 in Helsinki.

The meeting will take place in Helsinki University Meilahti Campus on August 26-27, 2014. In addition, an informal get-together and social networking event with buffet dinner and sauna option will take place on Tuesday August 26.

Tentative Programme

Each session will be opened by general lectures given by well-known scientists in the field, followed by a number of oral communications selected from submitted abstracts. The meeting will also have a poster-session and networking opportunities.

Tuesday, August 26, 2014

Venue: Haartman Institute, lecture hall 1 (Haartmaninkatu 3, 00290 Helsinki)

Opening remarks

9.00 - 9.30          
Ingunn Tho, President of the CRS Nordic Chapter and Jouni Hirvonen, Dean of the Faculty of Pharmacy, University of Helsinki

Drug delivery of poorly soluble compounds (Chair Christel Bergström, Uppsala University)

9.30 - 10.00       
Thomas Rades (University of Copenhagen), Amorphous drugs in multicomponent systems: old challenges and new solutions

10.00 - 10.30     
Patrick Augustijns (University of Leuven), Physiologically relevant dissolution and absorption evaluation of poorly soluble drugs and their formulations

10.30 - 11.00     
Ben Boyd (Monash University), Lipid-based formulations for poorly water soluble drugs – pro-colloidal systems?, pro-amorphous or crystalline salts or precipitates?, but certainly not passive delivery vehicles…

11.00 - 11.10
Matthew F. Crum: A coupled in vitro digestion-in situ jejunum absorption model provides mechanistic insight into drug absorption from lipid-based formulations

11.10 - 11.20
Marcus Brewster:  Development of a liquid oral nanosuspension for a novel poorly water-soluble drug candidate

11.20 - 11.30     
Panel discussion session of the short oral presentations

Lunch (Biomedicum lobby B1; Haartmaninkatu 8, 00290 Helsinki)

Novel drug development technologies (Chair Leena Peltonen, University of Helsinki)

12.30 - 13.00     
Niklas Sandler (Åbo Akademi University), title to be announced

13.00 - 13.30     
Erem Bilensoy
(Hacettepe University): Cationic hybrid nanoparticles as delivery systems for anticancer drugs via oral, mucosal or parenteral routes

13.30 - 13.40   
Neha Shrestha: Chitosan-modified porous silicon microparticles for enhanced intestinal permeability of insulin

13.40 - 13.50     
Erkan Sözeri: Label-free imaging of live intestinal cells using CARS microscopy

13.50 - 14.00     
Paul Stein: Distribution, diffusion and permeability measured with time-resolved localized NMR spectroscopy

14.00 - 14.10    
Massimiliano di Cagno: β-cyclodextrin-dextran polymers for the solubilization of poorly soluble drugs

14.10 - 14.30     
Panel discussion session of the short oral presentations

Coffee and refreshments, Poster Session (Haartman Institute, lecture hall 1 lobby)

Drug transporters and delivery (Chair Bente Steffansen, University of Copenhagen)

15.30 - 16.00     
Carsten Uhd Nielsen
(University of Copenhagen): Proton-coupled amino acid transporter (PAT1) mediated absorption of GABA-mimetics: In Vitro and In Vivo findings

16.00 - 16.30     
Per Artursson (Uppsala University): Prediction of the impact of transport mechanism on intestinal drug absorption

16.30 - 17.00     
Joseph Nicolazzo
(Monash University): Reduced blood-brain barrier transport of therapeutics in Alzheimer’s disease

17.00 - 17.10     
Nicolas Darville: Coherent anti-Stokes Raman scattering (CARS) microscopy as a tool for label-free investigation of nanoparticle-cell interactions in various biological matrices

17.10 - 17.20     
Sara Munk Jensen
: Extraction of Archaeal membrane lipids from Sulfolobus islandicus

17.20 - 17.30     
Panel discussion session of the short oral presentations


Wednesday, August 27, 2014

Venue: Biomedicum, lecture hall 2 (Haartmaninkatu 8, 00290 Helsinki)

Biomolecular delivery (Chair Ingunn Tho, University of Oslo)

9.00 - 9.30          
Gerrit Borchard (University of Geneva): Delivery of biopharmaceuticals using layer-by-layer technology: the do’s and don't’s

9.30 - 10.00       
Teruna Siahaan (University of Kansas): Cell adhesion molecules for drug delivery and targeting

10.00 - 10.30     
Steven Schwendeman
(University of Michigan): title to be announced

10.30 - 11.00     
Christian Schøneich (University of Kansas): title to be announced

11.00 - 11.10     
Francisca Araújo
: Characterization of chitosan-based nano-particles for improving oral delivery of GLP-1

11.10 - 11.20     
Sven Engström
: Nanoparticles and proteins crossing stratum corneum by means of water responsive lipid cubic phases

11.20 - 11.30     
Panel discussion session of the short oral presentations

11.30 - 11.40     
Closing remarks, Ingunn Tho, President of the CRS Nordic Chapter and Jouni Hirvonen, Dean of the Faculty of Pharmacy, University of Helsinki


The poster size should not exceed 90 cm wide x 120 cm high

In Silico Prediction of Glass Stability from Molecular Descriptors using Support Vector Machine
Amjad Alhalaweh, Ahmad Alzghoul, Denny Mahlin, Christel A.S. Bergström

Computational Models to Predict Glass-Forming Ability and Crystallization Tendency of Drug Molecules
Amjad Alhalaweh, Ahmad Alzghoul, Waseem Kaialy, Denny Mahlin, Christel A.S. Bergström1*

Applying Computational Methods to Predict Glass Transition Temperature of Drug Molecules
Ahmad Alzghoul, Amjad Alhalaweh, Denny Mahlin, Christel A.S. Bergström

Small scale dissolution profiling of highly lipophilic compounds under physiological conditions
Sara B.E. Andersson, Jonas H. Fagerberg and Christel A.S. Bergström.

In silico prediction of intravitreal primary pharmacokinetic parameters and drug concentrations: tool for ocular drug development
Eva M. del Amo, Kati-Sisko Vellonen, Heidi Kidron, and Arto Urtti

Concomitant intake of alcohol increases the absorption of poorly soluble drugs administered as immediate release formulations
Jonas H. Fagerberg, Erik Sjögren, Christel A.S. Bergström

Computational prediction of apparent solubility of lipophilic drugs in aspirated human intestinal fluid
Jonas  H. Fagerberg, Eva Karlsson, Johan Ulander, Gunilla Hanisch, C. A-S. Bergström

Microcontainers as an oral drug delivery system
Line Hagner Nielsen, Stephan Sylvest Keller, Jette Jacobsen, Thomas Rades, Anette Müllertz, Anja Boisen

Co-amorphous mixtures of simvastatin and glibenclamide with amino acids
Riikka Laitinen, Korbinian Löbmann, Holger Grohganz, Clare Strachan, Thomas Rades

Microfluidic assembly monodisperse polymer/porous silicon composites for precisely controlled multidrug delivery
Dongfei Liu, Hongbo Zhang, Bárbara Herranz-Blanco, Ermei Mäkilä, Vesa-Pekka Lehto, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos

Supersaturation of zafirlukast in fasted and fed intestinal media measured in situ by UV/vis fiber-optic probes: effectiveness of precipitation inhibitors
Cecilie M. Madsen, Anette Müllertz, Thomas Rades

Transdermal delivery of flufenamic acid from PLGA nanoparticles by iontophoresis
K. Malinovskaja, H. Labouta, M. Schneider, T. Laaksonen, J. Hirvonen

Assessment of computational and experimental models for prediction of drug solubility in triglycerides
Linda C. Persson, Angelica S.S. Friberg and Christel A.S. Bergström

Double layer polymer coated porous silicon nanovehicles for enhanced cellular interaction and endosomal escape
Mohammad-Ali Shahbazi, Patrick V. Almeida, Ermei M. Mäkilä, Martti H. Kaasalainen, Jarno J. Salonen, Jouni T. Hirvonen, Hélder A. Santos

Impact of human SGLT (SLC5A) mediated transport on apparent permeability can be studied in the in vitro DSMZ -Caco-2 cell model
Bente Steffansen, Abel Malek Laghmoch and Carsten Uhd Nielsen

Spectroscopic characterization of the formation and binding affinities of the PLL- and PEI- polymer-DNA polyplexes
E. Vuorimaa-Laukkanen, T.-M. Ketola, E. S. Lisitsyna, Martina Hanzlíková, C. J. Bishop, E. Morin-Pickardat, F. M. Winnik, J. J. Green, A. Urtti and M. Yliperttula

Effect of the surface functionalization of porous silicon nanoparticles on the cell uptake and prevention of complement C3 activation
Chang-Fang Wang, Ermei Mäkilä, Colin Bonduelle, Jussi Rytkönen, Sérgio Almeida, Jarno Salonen, Sebastien Lecommandoux, Jouni Hirvonen, Hélder A. Santos

Participation fee of 60 Euros includes the scientific sessions, lunches and refreshments as indicated in the programme. Abstract deadline for the event is June 15, 2014 (Abstract template). Abstracts can be sent to Satu Sainio (satu.sainio(at) Oral presentations will be selected from the submitted abstracts.

Registration fee to the Nordea bank account
IBAN: FI2216603000077738

is expected by July 1, 2014.
Please also inform your registration by email to Satu Sainio (satu.sainio(at)

Please include your name and the code for the meeting, wbs 7553020, in the payment information. On-site registration is also possible at a rate of 75 Euros.

Organizing Committee
Christel Bergström, Uppsala University, SE
Martin Brandl, University of Southern Denmark, DK
Jouni Hirvonen, University of Helsinki, FI
Leena Peltonen, University of Helsinki, FI
Jarkko Rautio, University of Eastern Finland, FI
Niklas Sandler, Åbo Akademi University, FI
Bente Steffansen, University of Copenhagen, DK
Ingunn Tho, University of Oslo, NO
Marjo Yliperttula, University of Helsinki, FI