Mouse Behavioural Phenotyping Facility (MBPF)

Modern neuroscience is a multidisciplinary approach to understanding nervous system at levels ranging from the molecular and cellular to the behavioral and cognitive. Mouse genetic models play a key role in the investigation of molecular pathways underlying normal biological functions or pathological states of the organism. These models require extensive systemic and systematic analysis at various levels of complexity.

Behavioural phenotyping is an important approach in comprehensive studies aimed at understanding psychiatric and neurological disorders. However, new strategies for refined assessment of mouse behaviour in laboratory conditions are developed continuously. Therefore, a growing need for expertise in this considerably new and expanding field exists.
MBPF is a state-of-the-art core facility providing equipment and professional assistance (including design, implementation, analysis and interpretation of the studies) for researchers interested in behavioural or neuropharmacological examination of the mice.
MBPF is located in newly renovated Laboratory Animal Center (LAC). This combination creates a strong infrastructure to support the research with rodent models.
MBPF allows access to wide range of behavioural tests and models:

  • Species-specific behaviour (nest-building, burrowing)
  • Circadian activity in home cage
  • Motor behaviour, coordination and balance (rota-rod, multiple beams, grip strength)
  • Nociception (hot plate, tail withdrawal, plantar test, automated von Frey)
  • Vision (visual cliff)
  • Taste (two-bottle test)
  • Hearing (acoustic startle reflex)
  • Sensorimotor gating (prepulse inhibition of acoustic startle reflex)
  • Social behavior (3-compartment test, social preference/avoidance, dominance, interaction)
  • Ultrasonic vocalisations
  • Videotracking (EthoVision) in various experimental conditions
  • Emotional behaviour (elevated plus maze, light-dark box, open field, forced swim test, tail suspension test, stress-induced hyperthermia, novelty-suppressed feeding)
  • Learning and memory (spatial navigation in water maze, classical fear conditioning, conditioned taste aversion, novel object recognition, T-maze, Y-maze, radial maze)
  • Novel, home-cage based system IntelliCage allows fully automated monitoring and analysis of behavioural and cognitive functions in group-housed mice over shorter or longer periods of time
Researchers interested in using the facility are advised to contact the director for discussing the details of planning and conducting the experiments.

 

Personnel
Director: Vootele Vőikar, MD, PhD
vootele.voikar-at-helsinki.fi
tel. 050-4160466