Laboratory of Neurobiology ::publications

PubMed Search for Kai Kaila

Reviews and book chapters by Kai Kaila

Books written or edited by Kai Kaila

Selected research articles:

Blaesse P, Airaksinen MS, Rivera C, Kaila K (2009). Cation-chloride cotransporters and neuronal function. Neuron 61:820-838.

Sipilä ST, Huttu K, Yamada J, Afzalov R, Voipio J, Blaesse P, Kaila K (2009): Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus. J Neurosci 29:6982-6988.

Khirug S, Yamada J, Afzalov R, Voipio J, Khiroug L, Kaila K. (2008): GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J Neurosci. 28(18):4635-4639.

Vanhatalo S, Kaila K. (2008): Generation of 'positive slow waves' in the preterm EEG: By the brain or by the EEG setup? Clin Neurophysiol. 119:1453-1454.

Schuchmann S, Tolner EA, Marshall P, Vanhatalo S, Kaila K. (2008): Pronounced increase in breathing rate in the "hair dryer model" of experimental febrile seizures. Epilepsia 49:926-928.

Colonnese MT, Phillips MA, Constantine-Paton M, Kaila K, Jasanoff A (2008). Development of hemodynamic responses and functional connectivity in rat somatosensory cortex. Nat Neurosci 11:72-79.

Li H, Khirug S, Cai C, Ludwig A, Blaesse P, Kolikova J, Afzalov R, Coleman SK, Lauri S, Airaksinen MS, Keinänen K, Khiroug L, Saarma M, Kaila K, Rivera C (2007). KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development. Neuron 56:1019-1033.

Huberfeld G, Wittner L, Clemenceau S, Baulac M, Kaila K, Miles R, Rivera C (2007). Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J Neurosci. 27: 9866-9873.

Schuchmann S, Schmitz S, Rivera C, Vanhatalo S, Mackie K, Sipila ST, Voipio J, Kaila K (2006) Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. Nature Med, 12: 817-823.

Sipilä ST, Schuchmann S, Voipio J, Yamada J, Kaila K (2006). The Na-K-Cl cotransporter (NKCC1) promotes sharp waves in the neonatal rat hippocampus. J. Physiol. 573 (Pt3): 765-773.

Palva JM, Palva S, Kaila K. (2005). Phase synchrony among neuronal oscillations in the human cortex. J Neurosci. 25:3962-3972.

Sipilä S, Huttu K, Soltesz I, Voipio J, Kaila K. (2005). Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive 'Giant Depolarizing Potentials' in the immature hippocampus. J Neurosci. 25:5280-5289.

Khirug S, Huttu K, Ludwig A, Smirnov S, Voipio J, Rivera C, Kaila K, Khiroug L. (2005). Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices. Eur J Neurosci. 21:899-904.

Sipila S, Huttu K, Voipio J, Kaila K. (2004). GABA uptake via GABA transporter-1 modulates GABAergic transmission in the immature hippocampus. J Neurosci. 24:5877-5880.

Rivera C, Voipio J, Thomas-Crusells J, Li H, Emri Z, Sipilä S, Payne JA, Minichiello L, Saarma M, Kaila K. (2004). Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J. Neurosci. 24:4683-4691.

Vanhatalo S, Palva JM, Holmes MD, Miller JW, Voipio J and Kaila K. (2004). Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep. Proc Natl Acad Sci USA 101:5053-5057.

Ruusuvuori E, Li H, Huttu K, Palva JM, Smirnov S, Rivera C, Kaila K and Voipio J. (2004). Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells. J Neurosci 24:2699-2707.

Santhakumar V, Voipio J, Kaila K, Soltesz I. (2003). Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassium. J. Neurosci. 23:5865-76.

Vanhatalo S, Holmes MD, Tallgren P, Voipio J, Kaila K, Miller JW (2003). Very slow EEG responses lateralize temporal lobe seizures: an evaluation of non-invasive DC-EEG. Neurology 60:1098-1104.

Rivera C, Thomas-Crusells J, Lahtinen H, Viitanen T, Nanobashvili A, Kokaia Z, Airaksinen MS, Voipio J, Kaila K, Saarma M (2002). BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J. Cell Biol. 159:747-752.

Gulyás, A.I., Sík A., Payne J.A., Kaila K., and Freund T.F. (2001). The K-Cl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus. Eur. J. Neurosci. 13:2205-2217.

Palva M., Lamsa K., Lauri S.E., Rauvala H., Kaila K., Taira T. (2000). Fast network oscillations in the newborn rat hippocampus. J. Neurosci. 20: 1170-1178.

Rivera C., Voipio J., Payne J.A., Ruusuvuori E., Lahtinen H., Lamsa K., Saarma M., Kaila K. (1999). The K-Cl cotransporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397, 251-255.

Kaila K., Lamsa K., Smirnov S., Taira T., Voipio J. (1997). Long-lasting GABA-mediated depolarization evoked by high-frequency stimulation in pyramidal neurons of rat hippocampal slice is attributable to a network-driven, bicarbonate-dependent K+ transient. J. Neurosci. 17, 7662-7672.

Kaila K., Voipio J., Pasternack M., Paalasmaa P., Deisz R. (1993). The role of bicarbonate in GABAA receptor-mediated IPSPs of rat neocortical neurons. J. Physiol. 464: 273-289.

Kaila K., Voipio J. (1987). Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature 330: 163-165.

Blaesse P, Airaksinen MS, Rivera C, Kaila K (2009). Cation-chloride cotransporters and neuronal function. Neuron 61:820-838.

Vanhatalo S, Voipio J, Kaila K 2009: Infraslow EEG activity. In: Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, 6th edition, Eds. Niedermeyer E, Lopes da Silva F, pp. 489-493. Baltimore-Munich: Williams&Wilkins (in press).

Sipilä ST, Blaesse P, Kaila K 2009: Development of GABAergic signaling: from molecules to emerging networks. In: Oxford Handbook of Developmental Behavioral Neuroscience. Eds: Blumberg MS, Freeman JH, Robinson SR. Oxford University Press (in press).

Schuchmann S, Vanhatalo S, Kaila K (2009). Neurobiological and physiological mechanisms of fever-related epileptiform syndromes. Brain and Development 31:378-382.

Vanhatalo S, Kaila K 2009: Emergence of spontaneous and evoked EEG activity in the human brain. In: The Newborn Brain: Neuroscience and Clinical Applications (2nd Ed). Eds. Lagercrantz H, Hanson M., Evrard P, Rod C. Cambridge University Press: Cambridge (in press).

Sipilä ST, Kaila K 2008: GABAergic Control of CA3-driven network events in the developing hippocampus. In: Inhibitory Regulation of Excitatory Neurotransmission, Ed. Mark Darlison, Springer-Verlag, Heidelberg. Results Probl Cell Differ. 44:99-121.

Buzsáki G, Kaila K, Raichle M (2007). Inhibition and brain work. Neuron 56(5):771-783.

Farrant M, Kaila K (2007). The cellular, molecular and ionic basis of GABA(A) receptor signalling. Prog Brain Res. 160:59-87.

Sipilä ST, Kaila K (2007). GABAergic Control of CA3-driven network events in the developing hippocampus. In: Inhibitory Regulation of Excitatory Neurotransmission, Ed. Mark Darlison, Springer-Verlag, Heidelberg. Results Probl Cell Differ Jul 11, 2007.

Vanhatalo S, Kaila K. (2006). Development of neonatal EEG activity: From phenomenology to physiology. Semin Fetal Neonatal Med. 11:471-478.

Vanhatalo S, Voipio J, Kaila K (2005). Full-Band EEG (FbEEG): an emerging standard in electroencephalography. Clin Neurophysiol 116(1):1-8.

Rivera C, Voipio J, Kaila K (2005). Two developmental switches in GABAergic signalling: the K-Cl cotransporter KCC2, and carbonic anhydrase CAVII. J Physiol 562:27-36.

Vanhatalo S, Miller JW, Holmes MD, Kaila K, Voipio J (2005). Full-band EEG in locating slow ictal events. In: Epilepsy Surgery: Principles and Controversies, Eds. Miller JW and Silberstein D. Marcel Dekker.

Vanhatalo S, Voipio J, Kaila K (2004). Infraslow EEG Activity. In: Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, 5th edition. Eds. E. Niedermeyer and F Lopes da Silva, pp. 489-493. Lippincott Williams & Wilkins, Philadephia.

Payne JA, Rivera C, Voipio J, Kaila K (2003). Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci. 26:199-206.

Voipio J, Kaila K. (2000). GABAergic excitation and K⁺ -mediated volume transmission in the hippocampus. Prog Brain Res. 125:329-38.

Ballanyi K., Kaila K. (1998). Transmitter-evoked shifts in intracellular pH. In: pH and Brain Function. Ed. K. Kaila and B. Ransom, pp. 291-308. Wiley-Liss, New York.

Kaila K., Chesler M. (1998). Synaptically-evoked extracellular pH transients. In: pH and Brain Function. Ed. K. Kaila and B. Ransom, pp. 309-337. Wiley-Liss, New York.

Kaila K., Ransom B. (1998). Concept of pH and its importance in neurobiology. In: pH and Brain Function. Ed. K. Kaila and B. Ransom, pp. 3-10. Wiley-Liss, New York.

Kaila K. (1994). Ionic basis of GABA-A receptor channel function in the nervous system. Prog. Neurobiol. 42: 489-537.

Chesler K., Kaila K. (1992). Modulation of pH by neuronal activity. Trends Neurosci. 15: 396-402

Kaila K., Voipio, J. (1990). GABA-activated bicarbonate conductance: influence on EGABA and on postsynaptic pH regulation. In: Chloride Channels and Carriers in Nerve, Muscle and Glial Cells. Ed. F.J. Alvarez-Leefmans, J.M. Russell, pp. 331- 353. Plenum Press, New York.

Kaila K. (1990). New views on classical inhibition. IBRO News 18/2: 7

Kaila K., Ransom B. (eds) 1998: pH and Brain Function. Wiley-Liss, New York.

Kaila K. 1985: Textbook (in Finnish): Hermoston ja käyttäytymisen biologiaa. Otava, Helsinki. (A Primer of Behavioural Neurobiology.)

News & views

YLE Terveys: Kuumekouristusten hoitoon hiilidioksidia? (2006)

Palolahti: Haastattelussa akatemiaprofessori Kai Kaila (2005)

Kai Kaila: Neurobiologia – Silta fysiikasta psykologiaan (1998)

Kai Kaila, Esa Kuismanen: Nykybiologian maailmankuva (1999)

Dissertations

Hong Li: Structural and functional roles of KCC2 in the developing cortex (2008) pdf

Sampsa Sipilä: Cellular and network mechanisms
generating spontaneous population events in the immature rat hippocampus (2006) pdf

Matias Palva: Interactions among neuronal oscillations in the developing and adult brain (2005) pdf

Marylka Uusisaari: GABAergic mechanisms of excitation and hypersynchrony in adult rat hippocampus (2003) pdf

Karri Lämsä: GABA_A Receptor-Mediated Excitation in the Hippocampus of Adult and Newborn Rats (2000) pdf

Katri Wegelius: Distribution and Function of GABA Receptor rho Subunits in the Rat Nervous System (2000) pdf

Sari Lauri: Heparan Sulfate-Dependent Cell-Extracellular Matrix Interactions in the Regulation of Hippocampal Long-Term Potentiation (LTP) (1999)

Sergei Smirnov:Intrinsic Ionic Modulation of Excitatory and Inhibitory Synaptic Transmission in the Hippocampus (1998)

Pekka Paalasmaa:Ionic Mechanisms Underlying Activity-induced Alkaline Transients in the Extracellular Space of the Brain (1996)

Tomi Taira: Mechanisms and Consequences of Interstitial pH Transients Evoked by Synaptic Activity in the Brain (1995)

Michael Pasternack: Ionic Mechanisms of GABA Action in Excitable Cells (1992)

Last modified: October 26, 2009