Courses


MNEURO
Neuroscience Center
P.O. Box 56 (Viikinkaari 4)
FIN-00014 University of Helsinki
FINLAND

Contact person:
Katri Wegelius, PhD, Coordinator
Department of Biosciences
P.O.Box 65 (Viikinkaari 1)
00014 University of Helsinki
Finland

+358 50 448 0405

mneuro-coordinator at helsinki.fi

 


 

Blackboard

WebOodi



 

Courses

Neurons, photo: Aino Vesikansa

updated 14.12.2016

COURSE PLAN FOR 2016-17

Courses and lectures can be found from the Search for courses -website

FALL 2016

920001 Molecular and cellular neuroscience
52271 Electrophysiological techniques
522021 Neurobiophysics 2
522049 Lectures in laboratory animal science
522085 Laboratory animal science: design of procedures and projects
522055 Practical work in laboratory animal science
52277 Brain slice eletrophysiology
921234 Building bridges: Brain Development, Early Vulnerability and Disorders

SPRING 2017

920002 Developmental neuroscience
920003 Functional neuroanatomy
920016 Brain dynamics
59084 Neuropharmacology
51083 Neurotransmitter receptors
920028 Basic methods in molecular neurobiology
920022/52098 Phenotypic analysis of transgenic animals

Courses without specific timing

920023 Personal Study Plan
52232 Final Examination in M.Sc. Degree in Neuroscience
50144 Master´s Thesis
570018-570023 Maturity Essay
920027 Practical Training
920000 Neuroscience Seminar Series
920012 MNEURO seminar
52276 Seminar in Neurobiology and Laboratory Demonstrations
920026 Book Examination in Cognitive Neuroscience

Courses not organized this year

920030 Optogenetics in neuroscience
920008 Optical imaging in neuroscience
522020 Neurobiophysics 1
920029 Neuroepigenetics
920031 Neuroregeneration
920015 Basic methods in neural cell culture
920007 Basic mechanisms of nervous system disorders
52265 Introduction to neurobiology (fall 2017)
920006 Synaptic signalling and plasticity, lectures
920024 Translational Neuroscience
920025 Behavioural phenotyping of mutant mice
920017 Data analysis in systems neuroscience

 

Other courses in English organized by Physiology and neuroscience.

Other courses in English organized by TRANSMED program.

Other courses in English organized by MBIOT program.

Other courses in English organized by Doctoral Programme Brain & Mind

Other courses in English organized by the Institute of Behavioral Sciences.

Other courses organized by Aalto University Department of Neuroscience and Biomedical Engineering

 

General book exam dates in Flamma >>>


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920001 Molecular and Cellular Neuroscience
Credits 6 Cr
Timing, place, program and registration
Timing 5.9.-28.11.2016 (Mon-Fri 10-12)
Place Neuroscience Center, Viikinkaari 4, Seminar Room B105
Responsible person Sari Lauri
Objective The purpose of the course is to give an overview of molecular mechanisms that regulate functions of the nervous system.
Contents The topics of the course are: Basic organization and cell types of the nervous system; Electrical signaling in the nervous system; Introduction to nervous system development; Plasticity in the nervous system; Ion channels and transporters; Neurotransmitters and their receptors; Signaling mechanisms in glutamatergic synapses; Signaling microdomains in neurons and astrocytes; Neurotrophic factors and their receptors; Functional insights from neuronal receptor structures; Adhesion molecules of the nervous system; Neuronal motility and plasticity: Regulation by the cytoskeleton; Model organisms in neurobiological research; Behavioural genetics; Computational neuroscience; Human molecular genetics in neuroscience; Mechanisms of neurodegeneration; Neural regulation of the immune system.
Realisation and working methods Lectures + study group
Study materials and literature Lecture material; Purves et al., Neuroscience (Sinauer)
Evaluation Examination, grading scale 0-5.

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920002 Developmental Neuroscience
Credits 3 Cr
Timing 6.-10.2.2017 (daily 9-16)
Timing, place and registration
Responsible person Eero Castrén
Objective The purpose of the course is to give an overview of the development of the nervous system and neuronal communication.
Contents: The topics of the course are: General concepts of the nervous system development; Neuronal induction and patterning; Neurogenesis and neurogenic genes; Gliogenesis and myelinization; Development of neurotransmitter systems; development of the peripheral nervous system; Axon outgrowth and regeneration; Neuronal migration; Neuronal death, Neurobiology of aging; Synaptogenesis; Circuit formation; Refinement of neuronal circuits.
Realisation and working methods Lectures.
Study materials and literature: Purves et al., Neuroscience, Unit  IV, Sanes D. et al., Development of the Nervous system, Lecture material
Evaluation A written examination based the relevant sections of the textbook and on the review article material given during the course, grading scale 0-5.

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920006 Synaptic Signaling and Plasticity, lectures
Credits 3 Cr
Timing not organized this year
Responsible persons Sari Lauri and Tomi Taira
Relations to other study units Advanced knowledge in neurobiology and molecular biology is required. "920001 Molecular and cellular neuroscience" is highly recommended for those planning to attend the lectures.
Contents The aim is to familiarize the students with the concept, mechanisms and consequences of activity–dependent synaptic plasticity in the central nervous system. In particular, the course will concentrate on the mechanisms by which electrical neurotransmission is linked to molecular signalling cascades, to regulate the efficacy of synaptic transmission.
Realisation and working methods Lectures.
Evaluation Examination, grading scale 0-5.

 

920007 Basic Mechanisms of Nervous System Disorders
Credits 5 Cr
Timing not organized this year
Target group 1. MNeuro students in advanced stage of their studies; 2. Other under- and postgraduate students interested in mechanisms underlying nervous system diseases
Responsible persons Anna-Elina Lehesjoki and Pentti Tienari
Objective The purpose of the course is to give an overview of basic mechanisms and research paradigms of nervous system disorders. In the course the student will get familiar with selected nervous system disorders and the current understanding on the underlying pathophysiological mechanisms.
Contents The lectures are given both by expert basic researchers and clinicians. The topics include neurodegenerative, ischemic, neuroimmunological and neuropsychiatric diseases.
Study materials and literature Lecture material and specific scientific articles indicated by the lecturers
Completion Lectures (1.5 Cr); Lectures + examination (5 Cr)
Evaluation Examination, grading scale 0-5.
Other information Basic courses in neurobiology, genetics and molecular biology are recommended.

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920022/52098 Phenotypic Analysis of Transgenic Animals
Credits 3 Cr
Timing 16.-17.5.2017 (9-16)
Timing, place and registration
PlaceViikki Infocenter, lecture room 3
Responsible person Prof. Kai Kaila; more information from katri.wegelius(at)helsinki.fi
ObjectiveFamiliarizing students with different transgenic animal models and the theories and methods used in neurobiological research.
Contents The course is based on lectures of specialists on different animal models and analysing techniques and case studies.
Realisation and working methods Lectures and examination
Literature Material given by the lecturers, lecture notes and selected research articles
Evaluation Participation in lectures, exam (31.5.2016), evaluation scale 0-5
Registration WebOodi  

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920009/52265 Introduction to Neurobiology
Timing: Fall 2017
Credits 5 Cr
Responsible person Kai Kaila
Contents Neurobiology and its relationships to other fields of science, research methods, history of ideas and ideologies, biophysics of neuronal membranes,electrical and chemical signaling, ion channels and transporters, action and resting potentials, synaptic function and plasticity, information processing, genes and brains, learning and memory, motor system, neuroethology, sensations and perception, neurobiology or consciousness
Literature Lecture handouts and notes
Evaluation Examination. Grading scale 0-5.

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52271 Electrophysiological Techniques
Responsible person: Juha Voipio
19.9.-30.10.2016 (Mon-Fri afternoon)
Timing, place and registration
Objective: Understanding of electrophysiological techniques from microelectrodes to devices and from recording modes to data analysis.
Contents: 1) Theory: Electricity, concepts and principles; properties of preparations, microelectrodes and amplifiers; equivalent circuit representation; accuracy and sources of error in microelectrode measurements; single and two microelectrode current and voltage clamp techniques; other microelectrode techniques; mechanisms of noise coupling and means for noise reduction; safety in an electrophysiology laboratory. 2) Hands-on exercises start with simple equivalent circuits and basic recording devices, and continue on active model cells with research instruments. Students will learn how to perform current and voltage clamp experiments using one or two microelectrodes in continuous/bridge/discontinuous/whole cell/perforated patch recording modes.
Realisation and working methods: Lectures and laboratory work during afternoons (noon till about 5 PM daily) of two consecutive weeks.
Study materials and literature Course compendium, and written instructions for laboratory exercises.
Evaluation: Active participation is required. A written examination is based on the course compendium and the laboratory exercises. Grading scale 0-5.
Other information: Previous knowledge in basic neurobiology and elementary physics is required for good learning results. A maximum of nine students can be accepted to the course.
Registration: WebOodi

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920019/52277 Brain slice eletrophysiology
Time: 5.-16.12.2016
Timing, place and registration
Place: Biocenter 3, Viikinkaari 1, Room 1605 (bottom floor)
Responsible person: Mikael Segerstråle
Teachers: Mikael Segerstråle, Svetlana Molchanova, Tomi Taira, Vernon Clarke
Prerequisites: A strong background in neurophysiology.
Contents:The goal is to learn widely used methods in electrophysiology (field recordings and patch clamp) and learn how to set up a an electrophysiological experiment.
Literature: Articles are given at the course.
Realisation and working methods: Laboratory course.
Evaluation: Course laboratory work, written report. Grading scale 0-5.
Registration: WebOodi

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920003 Functional Neuroanatomy
Credits 3 Cr
Timing 25.-27.1.2017
Timing, place and registration
Responsible person Claudio Rivera
Relations to other studies Basic courses in neurobiology, genetics and molecular biology are recommended.
Objective The aim of the lectures is to introduce students with the basics of functional neuroanatomy and with the principles used to study the cell structure and connections of the nervous system.
Realisation and working methods Lectures.
Evaluation Examination, grading scale 0-5.


920015 Basic Methods in Neural Cell Culture
Credits 3 Cr
Timing: not confirmed
Responsible person
Relations to other study units “920001 Molecular and Cellular Neuroscience” is highly recommended for those planning to attend the course.
Objective The purpose of the course is to familiarize students with some basic neural cell culture and molecular biology techniques. Problem based learning approach.
Contents Aseptic working methods, establishment and maintenance of primary neural cell cultures, transfection, immunofluorescence stainings, and live cell imaging.
Realisation and working methods Lectures, demonstrations, laboratory exercises and course compendium
Study material and literature Will be provided during the course
Evaluation Pass/fail

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920028 Basic Methods in Molecular Neurobiology
Credits 0.5 Cr for Lectures, 2.5 Cr for practical course
Responsible persons Tomi Rantamäki
Timing: 30.1.-3.2.2017
Timing, place and registration
Relations to other study units Basic knowledge in neurobiology, genetics and molecular biology are required. General laboratory skills are required.
Objective The purpose of the lecture day is to give general overview of basic molecular neurobiology methods that are used in in vivo experiments.
The purpose of the practical course is to familiarize with the analysis of gene expression by reverse transcription - PCR (RT-PCR) and of protein levels by ELISA and Western Blot in brain tissue samples.
Contents The lectures give an overview of the protein chemistry and molecular biology techniques used to investigate protein and DNA and RNA levels, their modifications and interactions. The practical course involves brain dissection, sample preparation, RNA extraction, cDNA production, RT-PCR, protein extraction/purification, analysis of protein content, ELISA and WB analyses of rodent brain tissue.
Realisation and working methods 1 day lectures and 4 days practical course
Study materials and literature Lecture material and other material provided by teachers.
Evaluation Lectures: 100% attendance to lectures; Practical course:  written report. Grading scale pass/fail.
Other information The lectures are open for all registered students, 10 students will be selected for the practical course.

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920026 Book Examination in Cognitive Neuroscience
Credits 6 cr
Responsible person Satu Palva
Literature Gazzaniga, M.S., Ivry, R.B., Mangun, G.R., Steven, M.S. Cognitive neuroscience: The biology of the mind (Norton, New York, 4th edition)
Relations to other study units Prerequisite for the course "920016 Systems Neuroscience: Perception, attention,and memory".
Evaluation Grading scale 0-5.
Examinations General exam days
Registration At the latest one week before the exam to satu.palva(at)helsinki.fi

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920016 Systems Neuroscience: Perception, Attention, and Memory Brain dynamics
Credits
3 Cr
Timing 27.3.-7.4.2017
Timing, place and registration
Responsible person Satu Palva
Objective Overview of oscillations, synchronisation and criticality
Study materials and literature Will be provided during the course.
Realisation and working methods Lectures and examination.
Evaluation Grading scale 0-5.


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920017 Data Analysis in Systems Neuroscience
Credits
3 Cr
Timing: will not be organized this year
Responsible persons Alexander Zhigalov and Matias Palva
ObjectiveThe goal of this course is to present and explain the basic and advanced data analysis methods, principles of programming and representation of the results for the students who have background in bio- and neuroscience. 
Contents Software for data analysis and programming. Verification and description of data. Analysis of 1D time series. Analysis of 2D/3D time series. Clustering and classification of data. Statistical analysis of data.
Realisation and working methods Lectures/workshop in a small group.
Evaluation Exam, grading scale 0-5.

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920024 Translational Neuroscience
Credits 3 Cr
Timing will not be organized in 2016. However, a course "Building bridges: Brain Development, Early Vulnerability and Disorders" will be organized in September 29-30, 2016.
Responsible person
Objective
Understanding the basic principles of translation of academic discoveries to therapeutics for central nervous system -related disorders.
Contents Principles of drug development; Preclinical and clinical drug development activities; Regulatory affairs and quality management in drug development; Imaging and biomarkers in CNS drug development; Recent trends in CNS clinical trials; Economical aspects in drug development; Four case studies on successful/failed drug development projects.
Realisation and working methods Lectures, case studies.
Study materials and literature Will be provided during the course.
Evaluation Examination based on material distributed in lectures. Grading scale 0-5.

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920025 Behavioural Phenotyping of Mutant Mice
Credits 3 Cr
Timing not organized this year
Resposible person Vootele Võikar
Objective To give an overview of methods in behavioural neuroscience with special emphasis on analysis of mutant mice.
Contents General principles of animal models and study design; Mouse as a model organism for behavioural studies; Behavioural phenotyping of mouse models for neuropsychiatric disorders – emotional behavior, motor and sensory testing, learning and memory; Challenges of comprehensive phenotyping – role of environment, standardization of the procedures, genetic background; Ethological perspective and monitoring of mouse behavior in the home cage.
Realisation and working methods Lectures, demonstrations.
Study materials and literature Lecture material and sample articles; Crawley JN: What's Wrong With My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice (2nd Edition, 2007, John Wiley & Sons).
Evaluation Examination. Grading scale 0-5.

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522049 Lectures in Laboratory Animal Science
Credits
2 Cr
Timing19.9.-5.10.2016
Timing, place and registration
Responsible persons Mikael Segeratråle
Objective These lectures lead to C-category (scientist) competence to work with laboratory animals according to European (Convention 1986/ETS 123; Directive 86/609/EEC) and Finnish legislation (62/2006).
Contents1. Biology and husbandry of laboratory animals, 2. Microbiology and disease, 3. Genetics, 4. Health hazards and safe practices, 5. Design and conduct of animal experiments, 6. Anaesthesia, analgesia and experimental procedures, 7. Alternatives to animal use, 8. Ethical aspects and legislation, 9. Analysis of scientific literature.
Study materials and literature Handbook of Laboratory Animal Science (2nd edition), Vol 1, Essential Principles and Practices. Jann Hau and Gerald L. Van Hoosier, Jr. (eds). CRC Press, 2003, or other literature.
Realisation and working methods Lectures (40-45 h) and an examination.
Evaluation Examination. Grading scale 0-5.
Examination
Additional examinations on two general examination dates. For these exams, register via WebOodi at the latest one week before exam.
Registration WebOodi

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522020 Neurobiophysics 1
Timing not organized this year
Responsible teacher:
Juha Voipio
Objective: The aim of the course is to give a good knowledge and an understanding of ion channel biophysics from physical chemistry and early models such as the Hodgkin-Huxley model, to recent findings from structure-function studies.
Contents: Basic concepts and physics of ion channel function; the Hodgkin-Huxley model and voltage gated channels; physicochemical principles and mechanisms of function; structure-function relationships of ion channels including mechanisms of selective permeability, gating and block etc.; overviews on main types of ion channels; ion channels and cell physiology.
Realisation and working method: The course consists of lectures and examinations weekly or fortnightly on typically one or two book chapters at a time, respectively. Optional homework problems for extra credits (the standard number of credits is 6).
Study materials and literature: Hille B, Ion Channels of Excitable Membranes, 3rd edition, 2001, Sinauer. Review articles.
Evaluation: Grading scale 0 - 5.
Other information: Previous knowledge in neurobiology is required for good learning results. The two courses Neurobiophysics 1 and 2 may be studied in either order.


522021 Neurobiophysics 2
Timing
1st lecture on September 21st in Biocenter 3 building, 2nd floor, room 2701, library of the Division of Physiology and Neuroscience. Thereafter weekly exams at 4 PM and lectures at 5 PM.
Timing, place and registration
Responsible teacher:
Juha Voipio (Hanna Heikkinen)
Objective: The aim of the course is to give a good knowledge and an understanding of cellular neurophysiology, with emphasis on electrical signaling at the cellular level, on the methods of analyzing experimental data, and on examples of modelling.
Contents: Basic electricity; ion movements across membranes; linear and nonlinear properties of membranes; properties and modelling of dendrites; ion channels and statistical analysis of experimental data; synaptic transmission; origin and analysis of field signals; cellular neurophysiology; homework problems.
Realisation and working method: The course consists of lectures and examinations on typically two book chapters at a time and arranged weekly or fortnightly. A refresh exam (recommended). Homework problems.
Study materials and literature: Johnston D. & Wu S.M.-S.: Foundations of Cellular Neurophysiology, The MIT Press, 1995 (or a corresponding more recently published book). Review articles.
Evaluation: Approximately ten written examinations and a refresh exam (recommended), or alternatively one final exam. Grading scale 0 - 5.
Other information: Previous knowledge in neurobiology is required for good learning results. The two courses Neurobiophysics 1 and 2 may be studied in either order.

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920029 Neuroepigenetics
Credits: 2 Cr
Timing: not organized this year
Place: Neuroscience Center, Viikinkaari 4, Seminar Room B105
Responsible persons: Juzoh Umemori and Caroline Biojone
Requirements: Basic knowledge of genetics and molecular biology
Course description: First part of the lecture course cover a theory and an overview of methodological approaches to study the main epigenetic events: DNA methylation, histone modifications, RNA interference (including microRNAs).  Second part of the course review the most critical neuroepigenetic processes throughout the life cycle that mediate: neurodevelopmental disorders Rett syndrome, Prader-Willi/Angelman syndrome (genes expression according to their parental origin); sexual dimorphism of neuronal disorders; circadian cycle; and behavioral response to environmental risk factors (stress, substance use)
Literature: Lecture material and scientific articles
Evaluation: Examination. Grading scale 0-5.

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920030 Optogenetic techniques in neuroscience
Credits: lectures 0.5 ECTS; laboratory demonstrations and student presentations 2.5 ECTS
Responsible person:
Anastasia Ludwig
Teachers: A. Ludwig, P. Uvarov, P. Sakha, O. Llano, D. Molotkov
Time: will not be arranged this year
Objective: After the course you will:

  1. Know what optogenetic is
  2. Understand basics of optogenetic techniques
  3. Be ready to discuss the latest publications in the field of optogenetics
  4. Be able to select the technique suitable for your project

Contents:

1. Origin of proteins used in optogenetics
2. Genetically encoded biosensors
3. Optogenetic stimulation and inhibition of neurons
4. Light-induced gene expression
5. Optogenetic control of biochemical signals
6. Gene delivery approaches

Realization and working methods: Lectures, laboratory demonstrations, student presentations
Study materials and literature: Handouts of the lectures, scientific articles given at the course
Completion requirements: Lectures - 100% attendance; laboratory demonstrations and student presentations - completion of all given assignments
Evaluation: Exam, grading 0-5
Other information: Basic knowledge of molecular biology and neuroscience in required
Registration: WebOodi; maximum 12 students can attend laboratory demonstrations
Please describe why you are interested in this course, and specify whether you prefer to attend: (1) only lectures, (2) lectures + laboratory demonstrations + student presentations. Please explain how you would benefit from the demonstrations.
If there are more than 12 applicants, candidates for participating in the demonstrations and presentations will be selected based on the application.

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920031 Neuroregeneration
Timing: not organized this year
Credits: Lectures – 1 cr., practical demonstrations – 2 cr.
Responsible persons: Heikki Rauvala and Mikhail Paveliev
Requirements: Molecular and Cellular Neuroscience course passed.
Objective: to learn basic concepts and research methods for CNS regeneration after traumatic brain injury and spinal cord injury.
Contents: Molecular mechanisms and social impact of traumatic brain injury and spinal cord injury. Extracellular matrix and signalling pathways for axonal regeneration. Practical demonstrations: 1) cranial window and skull thinning models for traumatic brain injury studies. 2) Regeneration of fluorescently labelled dendrites and blood vessels – multiphoton imaging. 3) Spinal cord hemisection and drug delivery. 4) Behavioral tests for functional deficits and function regain after spinal cord injury.
Realization and working methods: Lectures, laboratory demonstrations.
Tutors: Heikki Rauvala, Mikhail Paveliev, Natalia Kulesskaya, Mikhail Kislin
Evaluation: pass/fail.

 

59084 Neuropharmacology
Credits 3 Cr
Timing: March-April 2017
Timing, place and registration
Responsible person Raimo Tuominen
More information and registration
This course is organized by the Faculty of Pharmacy. MNEURO students can register to the course by sending an email to ftdk-tentit(at)helsinki.fi. Please add your name, student number and degree program to the email.

 

51083 Neurotransmitter receptors
Credits 3 Cr
Timing: March-May 2017
Timing, place and registration
Responsible person Kari Keinänen
This course is organized by biochemistry major.


920023 Personal Study Plan
Credit
s 1 Cr
Responsible person Katri Wegelius

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52232 Final Examination in M.Sc. Degree in Neuroscience
Credits
8-12 Cr
Responsible person Sari Lauri
Literature The exam is based on selected exam books (e.g. Cowan, Sudhoff and Stevens: Synapses, 2003, 792 pp) and review articles.

50144 Master´s Thesis
Credits
40 Cr
Responsible person Sari Lauri

570018-570023 Maturity Essay
Credits 0 Cr
Responsible person Sari Lauri

920012 MNEURO Seminar
Credits
6 Cr
Responsible person Sari Lauri
Timing first meeting on September 23 at 10 am, Physiology library (Bio3)
Timing, place and registration
Target group: second year MNeuro students
Objectives: The objective is to engage students in the world of neuroscience research and develop their ability for scientific thinking. At the seminar, the students will practice both the written and oral communication skills in the neuroscience, get familiar with the local neuroscience research community as well as scientific publishing, funding and career opportunities.
Contents: scientific writing, publishing in peer reviewed scientific journals, presenting and defending scientific data, writing a research plan. Site visits to research laboratories in the field. The seminar will also support the writing process of Master’s thesis.
Completion: participation, active discussions, written tasks and oral presentations in the seminars


920027 Practical Training
Credits
6-10 Cr
Responsible person Sari Lauri
Objective To engage students in scientific thinking and to develop their ability for independent work and the reporting of results.
Contents Laboratory training in a research group operating at the university, a research institute or a company.
Completion A research proposal, a laboratory note book, and a written report.
Duration 4-7 weeks of full-time work.
Evaluation Laboratory work and a written report, grading scale pass/fail.

920000 Neuroscience Seminar Series
List of seminars
To obtain the credits, please ask a signature from the host of the seminar to verify your attendance. The signed document should contain the date and the name of the speaker (see the attached form)
Credits
20 attended seminars = 1.5 Cr
Responsible person Katri Wegelius

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