TRIMteam

Welcome to the TRacers In Molecular imaging (TRIM) team!

Radiopharmaceutical chemistry includes selection, radiosynthesis and preclinical evaluation of radiolabelled compounds. As a research field it combines knowledge from medicinal and organic chemistry, radiochemistry and biomedical sciences.

Radiopharmaceuticals i.e. tracers labelled with short living, single photon emitting or positron emitting radionuclides are applied in non-invasive tomographic nuclear imaging modalities SPECT (single photon emission computed tomography) and PET (positron emission tomography). The main advantage of these imaging techniques is that they permit us to follow biodistribution and binding of administrated radiolabelled tracers in vivo, non-invasively and without significant signal attenuation dependent on the depth of the signal source. Due to this advantage, radiopharmaceuticals are used in nuclear medicine as diagnostic agents, in drug development in preclinical and clinical stage, and in biomedical research for studying disease mechanisms as well as normal physiology.

Radiopharmaceutical chemistry is one of the main research and teaching topics in the Laboratory of Radiochemistry. The main educational task of the laboratory is to teach safe handling of radionuclides and application of radionuclide methods, as well as to educate radiochemists for particular tasks, e.g. labelling of radiopharmaceuticals.