Dissertations

The Doctoral Programme in Clinical Research is coordinated by the Faculty of Medicine and belongs to the Doctoral school in health sciences. Doctoral candidates enrolled in the Doctoral Programme in Clinical Research receive the degree from the Faculty of Medicine.

The name of the Doctoral Programme in Clinical Research should appear on the title page of the thesis and doctoral candidates are encouraged to publish the thesis in the Dissertationes Scholae Doctoralis Ad Sanitatem Investigandam Universitatis Helsinkiensis series.


14.10.2016
Host- and Tumour-related Prognostic Factors in Diffuse Large B-cell Lymphoma
Riihijärvi, Sari

14.10.2016
A GREAT PERTURBATION IN NATURE : PARKINSON'S DISEASE AND SLEEP DISORDERS
Ylikoski, Ari

7.10.2016
Heritability and genetic risk factors in Finnish families with childhood otitis media
Hafrén, Lena

7.10.2016
FAMILIAL ADENOMATOUS POLYPOSIS: SCREENING, SURGERY AND DESMOID TUMOURS
Koskenvuo, Laura

7.10.2016
Outcome of pediatric cardiac surgery
Raissadati, Alireza

23.9.2016
Vitamin D deficiency and supplementation : Studies from infancy to young adulthood
Holmlund-Suila, Elisa

23.9.2016
Histamine Receptor 4 (H4R) in Pathogenesis of Sjögren's Syndrome
Stegajev, Vasili

9.9.2016
Perinatal regulation of lung liquid absorption in pulmonary adaptation in newborn infants
Janér, Cecilia

9.9.2016
Finnish pretrial male firesetters: mortality, suicidality, psychopathy, and morbidity of schizophrenia
Thomson, Annika

26.8.2016
Severe acute pancreatitis : Predicting with ecto-5'-nucleotidase (CD73) and treatment with activated protein C
Kyhälä, Lea

5.8.2016
Humoral beta-cell autoimmunity, AGER gene polymorphism, and circulating soluble RAGE in pre-clinical and clinical type 1 diabetes
Salonen, Kirsi

17.6.2016
Role of dehydroepiandrosterone in high-density lipoprotein-mediated vasodilation and in adipose tissue steroid biosynthesis
Paatela, Hanna

15.6.2016
INNATE IMMUNITY IN OSTEOARTHRITIS: THE ROLE OF TOLL-LIKE RECEPTORS AND CARTILAGE DERIVED MEDIATORS IN THE DISEASE PROGRESSION
Barreto, Gonçalo

11.6.2016
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency in Finland earlier diagnosis and strict diets improve the survival rate and clinical course
Immonen, Tuuli

10.6.2016
Contralateral approach to anterior circulation aneurysms
Andrade Barazarte, Hugo

10.6.2016
Treatment, Adherence, and Disability in Bipolar Disorder
Arvilommi, Petri

10.6.2016
ENDOSCOPIC THERAPY IN EXTRAHEPATIC BILIARY STRICTURES
Haapamäki, Carola

10.6.2016
Ultrasound in estimating lung liquid and parenchyma in children
Martelius, Laura

10.6.2016
Accelerated aging after hematopoietic stem cell transplantation in childhood: Early menopause, premature cardiovascular aging and frailty
Vatanen, Anu

3.6.2016
Posterior Cerebral Artery Aneurysms
Göhre, Felix

3.6.2016
Prevalence, predictors and prognosis of depressive disorders in the general population. : A longitudinal population study.
Markkula, Niina

27.5.2016
T AND NK CELL MEDIATED IMMUNITY IN CHRONIC MYELOID LEUKAEMIA
Ilander, Mette

27.5.2016
Acute severe complications of otitis media in children and adults
Laulajainen-Hongisto, Anu

27.5.2016
Incidence and outcome of out-of-hospital cardiac arrest patients in Finnish intensive care units
Vaahersalo, Jukka

20.5.2016
Increased fetal nuchal translucency in the first-trimester screening: pregnancy outcomes and a long-term follow-up of children
Äyräs, Outi

13.5.2016
SURGICAL TREATMENT AND CHARACTERISTICS OF CHRONIC MAXILLARY RHINOSINUSITIS
Koskinen, Anni

29.4.2016
Anorectal malformations - outcomes up to adulthood
Kyrklund, Kristiina

22.4.2016
Rectovaginal endometriosis - pain treatment options
Tarjanne, Satu

15.4.2016
Causes and consequeces of delay in vascular surgery
Noronen, Katariina

18.3.2016
Neutrophil gelatinase-associated lipocalin in kidney and liver transplantation
Hollmen, Maria

18.3.2016
Human herpesvirus 6, Varicella-Zoster virus and oligoclonal bands in demyeliating diseases of the central nervous system
Nicklen, Jenna

18.3.2016
Peritonsillar Abscess - Aetiology, Diagnostics and Treatment
Wikstén, Eeva Johanna

19.2.2016
Specific probiotics in the upper respiratory tract: colonization, efficacy and safety : with a focus on Lactobacillus rhamnosus GG
Tapiovaara, Laura

9.1.2016
Preoperative Risk-Assessment Methods, Short-Term Outcome, and Patient Satisfaction in Elective Cranial Neurosurgery
Reponen, Elina

2015

18.12.2015
Acute kidney injury in cardiac surgery
Ristikankare, Anne

17.12.2015
Children and adolescents with disruptive behavior and psychopathic-like features
Saukkonen, Suvi

11.12.2015
Infections, Strokes, and Brain : What are the outcomes?
Heikinheimo-Connell, Terttu

11.12.2015
Cardiac Sarcoidosis and Giant Cell Myocarditis in Finland
Kandolin, Riina

4.12.2015
Posterior urethral valves. Early features and renal outcome
Heikkilä, Jukka

27.11.2015
Trends in obstetric and perinatal outcomes of women with type 1 diabetes during 1988-2011 : A Finnish population-based observational study
Klemetti, Miira

27.11.2015
OUTCOME AFTER TRANSSPHENOIDAL SURGERY FOR PITUITARY ADENOMA - THE 2000-2010 HELSINKI UNIVERSITY HOSPITAL COHORT
Karppinen, Atte

27.11.2015
Sydänpysähdyksestä elvytetyn potilaan tehohoito
Oksanen, Tuomas

27.11.2015
Individual Trajectories in Asthma and COPD: A Longitudinal Perspective to Obstructive Lung Disease
Koskela, Jukka

20.11.2015
Risk-stratification of endometrial carcinoma: Prediction of an advanced disease and features of the primary tumor
Luomaranta, Anna

13.11.2015
Cancer immunotherapy with a gene modified serotype 3 oncolytic virus
Hemminki, Otto

13.11.2015
Intracerebral hemorrhage in young adults
Koivunen, Riku-Jaakko

6.11.2015
Studies on hemodynamics and coagulation in neuroanesthesia
Luostarinen, Teemu

6.11.2015
A study on genetic mutations involving mitochondrial disorders diagnostic approach and application of human iPSCs to understand disease pathogenesis
Polinati, Padmini

30.10.2015
Infant burns in Finland 1990-2010 - special emphasis on clinical characteristics and outcomes
Laitakari, Elina

28.10.2015
Novel factors in the pathogenesis of cutaneous T cell lymphomas
Maliniemi, Pilvi

12.10.2015
Clinical Use of Urinary Gonadotropin Determinations in Children and Adolescents
Demir, And

2.10.2015
Oncolytic adenovirus coding for GM-CSF in treatment of cancer
Bramante, Simona

18.9.2015
The Development of Immune Responses and Allergy in Children from Farming and Non-farming Environments
Orivuori, Laura

11.9.2015
Anxiety, depression, and anger in the borderland of chronic pain
Knaster, Peter

4.9.2015
Angiogenesis Inhibitors in Metastatic Renal Cancer with Emphasis on Prognostic Clinical and Molecular Factors
Rautiola, Juhana

28.8.2015
Disseminated intravascular coagulation in critically ill patients
Sivula, Mirka

14.8.2015
Management of pelvic ring injuries
Lindahl, Jan

12.6.2015
ADENOCARCINOMA OF THE ESOPHAGUS AND ESOPHAGOGASTRIC JUNCTION - STUDIES ON PATHOGENESIS, PROGNOSIS, STAGING AND SURGICAL TREATMENT
Kauppi, Juha

5.6.2015
Alkoholiriippuvuuden hoitotulokseen vaikuttavat tekijät
Laaksonen, Esti

5.6.2015
Matrix metalloproteinases and toll-like receptors in early-stage oral tongue squamous cell carcinoma
Mäkinen, Laura

5.6.2015
Fear of childbirth
Rouhe, Hanna

29.5.2015
TUMOUR GLYCOSYLATION AND GLYCOPROTEINS AS BIOMARKERS IN COLORECTAL CANCER
Kaprio, Tuomas

29.5.2015
DIAGNOSIS AND TREATMENT OF PREMALIGNANT CHANGES OF PHOTODAMAGED SKIN: Novel Hyperspectral Imaging and New Therapeutical Aspects
Neittaanmäki-Perttu, Noora

29.5.2015
The long-term outcome of frozen shoulder
Vastamäki, Heidi Anita

22.5.2015
NON-TRANSFERRIN-BOUND IRON IN HEMATOPOIETIC STEM CELL TRANSPLANTATION
Sahlstedt, Leila  

15.5.2015
Neuro-Ophthalmic Manifestations in Patients with Intracranial Aneurysms
Koskela, Elina

13.5.2015
Short- and long-term results and quality of life in open inguinal hernia repair
Pierides, Georgios

8.5.2015
Towards Better Patient Safety: The WHO Surgical Checklist in Otorhinolaryngology
Helmiö, Päivi

8.5.2015
AUTOLOGOUS BONE MARROW MONONUCLEAR CELL TRANSPLANTATION AND CORONARY BYPASS SURGERY FOR TREATMENT OF ISCHEMIC HEART FAILURE
Lehtinen, Miia

6.5.2015
Epidemiology of comorbidities in early rheumatoid arthritis: with emphasis on cardiovascular disease
Kerola, Anne

29.4.2015
Intrauterine contraception - Use in Nulligravid Women and Safety Aspects
Kaislasuo, Janina

24.4.2015
Improving attendance to cervical cancer screening: Effects of HPV-testing on self-taken samples in the Finnish cervical cancer screening programme
Virtanen, Anni

17.4.2015
Aneurysms of the vertebral and posterior inferior cerebellar arteries
Lehto, Hanna

10.4.2015
Munasarja- ja munajohdinsyövän riski vaihdevuosihormonihoitoa käyttävillä naisilla
Koskela-Niska, Virpi

27.3.2015
Utilization and costs of prescription medication in patients with type 1 diabetes: Impact of diabetic kidney disease
Lithovius, Raija

27.2.2015
New insights in Autoimmune Polyendocrine Syndromes 1 and 2
Kluger, Nicolas

27.2.2015
Changes in bone mineral content in the lumbar spine and femoral neck in rheumatoid arthritis and juvenile idiopathic arthritis: -focusing on long-term disease duration, premenopausal women, young adults, disease activity, and use of osteoporosis drugs
Hämäläinen, Harri

7.2.2015
Pain and associated procedural anxiety in adults undergoing bone marrow aspiration and biopsy: Therapeutic efficacy and feasibility of various analgesics
Kuivalainen, Anna-Maria

23.1.2015
Long-term outcome after pediatric renal transplantation: Endocrinologic and metabolic effects
Tainio, Juuso

23.1.2015
Lipid profile and micro- and macrovascular complications in type 1 diabetes
Tolonen, Nina

16.1.2015
Acute kidney injury in severe sepsis and septic shock
Poukkanen, Meri

16.1.2015
Airway Responsiveness and Inflammation in Young Children with Respiratory Symptoms
Kalliola, Satu

2014

19.12.2014
Physical activity, nutrition and stress response in young adults born preterm − determinants of health and disease: The Helsinki Study of Very Low Birth Weight Adults
Kaseva, Nina

19.12.2014
Prognostic Models in Traumatic Brain Injury
Raj, Rahul

12.12.2014
Long-term outcome of early rheumatoid arthritis: with special interest in comorbidity and permanent consequences of the disease
Tiippana-Kinnunen, Tarja

12.12.2014
Airway inflammatory markers in asthma and rhinitis: microRNA, nasal nitric oxide and proteome analysis
Suojalehto, Hille

12.12.2014
Regulation of Normal and Neoplastic Steroidogenic Cell Differentiation in the Adrenal Gland and Ovary
Pihlajoki, Marjut

21.11.2014
Effects of postmenopausal hot flushes and hormone therapy on quality of life and cardiovascular autonomic function
Hautamäki, Hanna

13.11.2014
Obesity, weight change and work disability - a follow-up study among middle-aged employees
Roos, Eira

17.10.2014
The Effect of Cardiovascular Stress on Cognition and Mortality : Studies on B-type Natriuretic Peptide amongst the Elderly Population
Hiltunen, Matti

10.10.2014
Completed and attempted suicides in relation to weather and daylight in Finland: Register based study from 1969 to 2010
Hiltunen, Laura

3.10.2014
Complications in Ankle Fracture Surgery
Ovaska, Mikko

26.9.2014
Assessment of myocardial infarction injury by strain rate imaging and body surface potential mapping
Kylmälä, Minna

19.9.2014
Health problems of Finnish travellers: Focus on infections
Siikamäki, Heli

6.9.2014
Staphylococcus aureus bacteraemia - Disease progression and prognosis
Forsblom, Erik Sebastian

6.9.2014
Fibromyalgia: Background factors and impact on mortality and ability to work
Markkula, Ritva

5.9.2014
Vestibular function in different otoneurological patients as measured by head tilt and head impulse test
Jutila, Topi

15.8.2014
A clinical and health economical observational study of anti-tumor necrosis factor therapy in the treatment of rheumatoid arthritis in Finland
Virkki, Liisa

6.6.2014
Role of breastfeeding in bone health, body composition and vascular health and their inter-connectivity: A follow-up study from birth to 32 years of age
Pirilä, Satu

6.6.2014
Survival of patients with type 1 diabetes on renal replacement therapy
Helve, Jaakko

6.6.2014
Molecular pathogenesis of large granular lymphocytic leukemia
Rajala, Hanna

28.5.2014
Cognitive function in opioid substitution treated patients: Associations with drug treatment variables
Rapeli, Pekka (National Institute for Health and Welfare)

28.5.2014
Clinical characteristics of cow's milk allergy with gastrointestinal symptoms
Merras-Salmio, Laura

23.5.2014
Incidence, biomarkers, and outcome of acute kidney injury in critically ill adults
Nisula, Sara

23.5.2014
Clavicle Injuries: Treatment of midshaft clavicle fractures and acromioclavicular joint dislocations in adults
Virtanen, Kaisa

23.5.2014
Screening and active surveillance in prostate cancer: prognostic and short-term outcomes of active surveillance and quality of life aspects
Vasarainen, Hanna

16.5.2014
Insulin therapy in type 2 diabetes : Initiation, impact on liver fat, role of combination therapy with glitazones or glindes
Juurinen, Leena

9.5.2014
Liver disease in pediatric onset intestinal failure
Mutanen, Annika

28.3.2014
Aberrant intracellular calcium cycling in the heart: mechanistic insights into catecholaminergic polymorphic ventricular tachycardia and heart failure
Paavola, Jere

28.2.2014
Monitoring treatment response in Crohn's disease
af Björkesten, Clas-Göran

8.2.2014
Early autonomic dysfunction in type 1 diabetes : Insights into its significance and mechanisms
Rosengård-Bärlund, Milla

31.1.2014
The quality of life and cost-effectiveness of treatment after a serious neurosurgical illness
Malmivaara, Kirsi (Helsingin yliopisto, VKTK)

24.1.2014
Predicting pre-eclampsia - Angiogenic factors and various forms of human chorionic gonadotropin
Keikkala, Elina (Helsingin yliopisto, VKTK)

24.1.2014
Osteogenetic growth factors around loosened hip replacements
Waris, Ville (Helsingin yliopisto, VKTK)