Biochemistry and Biotechnology - Research

The Division of Biochemistry is actively engaged in research and the major topics are cell membranes and signal transduction in eukaryotic cells. The research groups are studying biosynthesis of membrane proteins, their intracellular transport, protein structure, cell adhesion, intracellular signaling in normal and malignant cells and membrane associated metalloproteases.

Core Facilities:

Current research groups / projects in alphabetical order according to group leader

Professor Arto Annila: Biophysics

Description of natural processes by the 2nd law of thermodynamics. Protein NMR spectroscopy and small-angle scattering having emphasis on interaction phenomena, data interpretation and development of methods. >> Read more

Docent Eeva-Liisa Eskelinen: Lysosomal membrane proteins and autophagy in mammalian cells
The aims are to define the roles of the lysosomal membrane protein LAMP-2 in autophagy,
lysosome biogenesis, and intracellular cholesterol traffic, and to investigate the
mechanisms of autophagosome biogenesis and maturation. >> Read more

Professor Jukka Finne: Cell surface carbohydrates
Cell surface carbohydrates are important mediators of the interactions of cells and the external world. They are also involved in the pathogenesis of maladies such as cancer and bacterial diseases. >> Read more

Professor Carl G. Gahmberg: Molecular studies on leukocyte adhesion
Leukocyte adhesion is of pivotal functional importance. The group studies in molecular detail leukocyte integrins, how they bind to their ligands and how they are activated. The integrin ligands ICAM-4 and ICAM-5 form another major object of study. >> Read more

Professor Adrian Goldman
Our work, which aims at spatial cellular/structural biology, focuses on proteins and
protein complexes that are at and close to the cell surface, looking at neuronal protein interactions (e.g. GDNF-GFRα-RET and MANF),  at host-pathogen interactions,
such as those involving trimeric autotransporters, factor H and complement, and membrane integral pumps. >> Read more

Tuomas Haltia, docent, university lecturer: Biochemistry of denitrification
We are interested in metallo and membrane proteins and their structures and catalytic mechanisms. Our work involves growing bacteria, isolating membranes, purifying the proteins of interest and using a battery of methods to chacterise them. >> Read more

Professor Kari Keinänen: AMPA Receptors
We wish to understand at molecular level how the structure and molecular interactions of AMPA receptors, a major subclass of glutamate-gated ion channels, relate to their central role in excitatory synaptic neurotransmission. >> Read more

Pia Siljander, PhD, docent: Platelet-derived microparticles in health and disease
Platelets shed both microparticles and exosomes which can act as intercellular mediators
of information exchange in various physiological and pathological processes.