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Apply both the cDNA/
oligo and CGH microarrays in cancer (breast, gastric and head
and neck cancers) to study genes whose expression has changed due to
altered gene copy number (deletion or amplification). |
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Characterize the most interesting genes biologically
and functionally to identify promising targets for anti-cancer therapies. |
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Apply and develop novel microarray platforms,
including NMD, lysate, cell and functional microarrays for the target
validation and integration of the DNA, RNA, protein and cell level data. |
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Develop novel bioinformatics-based tools for the
analysis of microarray data. |
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Study the HOX gene family of transcription factors
and their role in systems biology of cancer. |
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Identify genetic variations predisposing to complex
diseases, such as cardiovascular diseases, multiple sclerosis,
osteoarthritis, discus degeneration and mental health disorders using SNP
microarrays. |
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Monitor for genetic variations predisposing to
complex diseases in large epidemiological study samples. |
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Apply oligonucleotide microarrays to study gene
expression differences in multiple sclerosis. |